Harmful Effects Research Articles

Investigation of red clay and waste glass composite bricks for ionizing radiation shielding

Ionizing radiation is valuable for healthcare, industry, and agriculture. However, excessive exposure to ionizing radiation is detrimental to humans and the environment. Radiation protection aims at protecting people and the environment from the harmful effects of ionizing radiation. This work aimed to study the effectiveness of composites of red clay and waste glass for ionizing radiation shielding. Five samples of different mix ratios of red clay to waste glass were fabricated into different dimensions using hand molding, dried, and burnt. The samples were characterized for ionizing radiation shielding. Monte-Carlo simulation was done using the GEANT4 toolkit and web-based NIST-XCOM photon attenuation database. The findings show that the measured half value layer (HVL) for the composite bricks showed a linear decrease from (6.13± 0.10) cm for the CNT sample that had 0 % waste glass to (4.62± 0.12) cm for the RCG11 sample that had 50 % waste glass. The GEANT4 simulated HVL values for CNT and RCG11 samples were (6.05±0.01) cm and (4.79±0.01) cm respectively. The NIST-XCOM values were (6.09±0.09) cm and (4.81± 0.01) cm for CNT and RCG11 respectively. The measured and simulated results were in good agreement. The findings of this study indicate an improvement in the shielding properties of red clay with the addition of waste glass and will promote radiation safety by providing an environmentally friendly alternative shielding material.•Proper shielding is key in promoting radiation safety and protection. There is a need for alternative shielding materials that can be used for walling during the construction of structures that house radioactive materials.•Red clay and waste glass composite bricks can provide alternative ionizing radiation shielding material.•This study will promote environmentally friendly practices in radiation safety and protection.

Endocrine disruptors effects in ruminant reproduction

Oral exposure to synthetic and natural endocrine disruptors (ED) at different stages of life is related to alterations in the reproductive system. Ruminants represent a model for studying the effects of ED in humans due to some similarities in their development. Ruminants are considered of great importance due to continuous exposure to pasture and contaminated soils and human consumption of their meat. The present review aims to describe ED effects in ruminants’ reproduction, when they are consumed in the perinatal, postnatal-pre-adulthood, and adult stages. Feeding with phytoestrogens (PE) rich forage has no nocive consequences on the male reproductive system at any stages of life; in females, they produce more significant harmful effects when administered in adulthood. In the perinatal and postnatal-pre-adulthood stages, negative effects of synthetic ED were found in both males and females. This review presents study opportunities for further research related to oral exposure to ED.

An Integrated Testing Strategy (ITS) to assess the environmental compatibility of wood protection techniques

To quantify the possible impact of different wood protection techniques on the aquatic environment, we applied a tiered Integrated Testing Strategy (ITS) on leachates obtained from untreated (UTW) Norway spruce (Picea abies), specimens treated with a copper-ethanolamine-based preservative solution, complying with the Use Class 3 (UC3), and specimens thermally modified (TM). Different maturation times in water were tested to verify whether toxicant leaching is time-dependent. Tier I tests, addressing acute effects on Aliivibrio fischeri, Raphidocelis subcapitata, and Daphnia magna, evidenced that TM toxicity was comparable or even lower than in UTW. Conversely, UC3 significantly affected all species compared to UTW, also after 30 days of maturation in water, and was not considered an environmentally acceptable wood preservation solution. Tier II (effects on early-life stages of Lymnea auricularia) and III (chronic effects on D. magna and L. auricularia) performed on UTW and TM confirmed the latter as an environmentally acceptable treatment, with increasing maturation times resulting in decreased adverse effects. The ITS allowed for rapid and reliable identification of potentially harmful effects due to preservation treatments, addressed the choice for a less impacting solution, and can be effective for manufacturers in identifying more environmentally friendly solutions while developing their products.

Eficiencia de los bioindicadores de toxicidad sobre contaminantes de aguas residuales industriales

In this paper, we present some important biological factors that modify the efficiency of toxicity bioindicators used to evaluate the harmful effect of industrial wastewater pollutants on biological organisms and processes, such as reproduction, growth and development. The Lactuca sativa model was analyzed and proposal for new biological parameters with fungi, bacteria, plants and animals that can be used as bioindicators of toxicity and ecotoxicity that do not directly compromise the survival of organisms in bioassays and environments contaminated with industrial wastewater effluents.

Measures implemented in the school setting to contain the COVID-19 pandemic.

Measures implemented in the school setting to contain the COVID-19 pandemic.

A case study on blast fishing in illegal small scale fisheries in the Aegean Sea: Catch composition and observed external and internal abnormalities for 18 Osteichthyes fish species

Blast fishing is an illegal, ecologically destructive fishing method, fatal for many fish species at large scales. Blast fishing using dynamite is preferred by the fishers, especially small scale fisheries in Turkey, as it requires minimal effort but still results in higher catches. In the current study, demonstration of 20 controlled real-time blasting results involves species composition, size of fish, catch rates, catch composition, commercial/discard ratios, CPUE estimates and clinical observations of external and internal abnormality symptoms of fish species. Blasting trials were carried out with special permission in limited numbers because of its harmful effect. The collected data was tested using PRIMER v6 and diversity indices were also analysed. For the similarity between collected species cluster analysis was used to examine the stability of the results. Multidimensional scaling (MDS) was also applied for the assessment of fish species in the catch. A total of 1014 individuals (63.8 kg) were collected and 18 fish species belonging to seven families were examined. According to laboratory examinations, it was found that blasting caused different external and internal abnormality symptoms in the sampled fish species during the study.

Abstract PO2-28-03: E-Cigarette Aerosol Exposure: Unraveling the Nexus of Autophagy, Cancer Stem Cells, and EMT in Breast Cancer Metastasis

Abstract Electronic cigarettes (E-cigs) have emerged as a significant public health concern due to their increasing popularity. These products have been associated with various harmful effects on human health. In the United States, breast cancer is the most diagnosed cancer among women, and its recurrence and metastasis are primary contributors to morbidity and mortality. Two critical factors in cancer progression are Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs), both of which play pivotal roles in metastasis. As a result, targeting the signaling pathways involved in these processes has become a promising avenue for cancer therapy. Autophagy, a cellular process, has dual roles in cancer development depending on the cancer type and stage. Given these considerations, our hypothesis centers on disrupting the EMT-mediated metastatic cascade in breast cancer by targeting autophagy in Cancer Stem Cells (CSCs). To investigate this hypothesis, we conducted experiments using mouse breast epithelial cells (HC11) and Triple-negative mouse breast cancer cells (4T1) exposed to E-cig aerosol at the air-liquid interphase (ALI) for 1 hr followed by a 24 hr recovery period. Our findings indicate that exposure to E-cig aerosols led to a decrease in epithelial markers (E-Cadherin and β-catenin) and an increase in mesenchymal markers (N-Cadherin and Vimentin) in HC11 cells. This suggests that normal cells may acquire characteristics associated with solitary migration. Furthermore, we observed significant changes in the levels of autophagy-related proteins (LC3B, Beclin-1, ATG12, and ATG16) and upregulation of stem cell markers (OCT4, SOX2, NANOG, KLF4, and c-MYC) in response to E-cig aerosol exposure, both in HC11 and 4T1 cells. Additionally, these alterations extended to changes in the expression of genes associated with the Transforming Growth Factor-beta (TGF-β) signaling pathway, known to play a potential role in promoting EMT. Our results provide a deeper understanding of the interplay between EMT, CSCs, and the autophagy process in the context of ALI exposure in normal and cancer cells. This underscores the need for further research into the shared molecular mechanisms of these three processes to identify common therapeutic targets that can simultaneously affect them. Citation Format: Shilpa Thota, Rizwana Begum, Naveen Chintalaramulu, Biplov Sapkota, Abhishek Pandit. E-Cigarette Aerosol Exposure: Unraveling the Nexus of Autophagy, Cancer Stem Cells, and EMT in Breast Cancer Metastasis [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-28-03.

Heavy Metal Stress Management through Phytoremediation to Mitigate Climate Change Impacts: An Overview

Plant stresses are the conditions that adversely affect the growth, development, or productivity of plants/trees and can be caused by various physical, chemical, and biological factors. However, stress caused by the influence of heavy metals has a notable adverse effect on plant growth and productivity. These heavy metal contaminations are responsible for the harmful effects on biotic (plants and associated organisms) and the abiotic (soil, water, and air) environment. If not properly managed, mining activities are considered to be the prime source of heavy metal contamination in the surrounding environment. Phytoremediation may effectively remediate a wide range of heavy metal contaminants in different environments and hence offers an effective, carbon-neutral, and ecologically beneficial method for the removal of hazardous heavy metal contaminants. Phytoremediation enhances the growth and development of plants and nourishes the environment resulting in the ill effects of climate extremes in disturbed areas and hence mitigating the impacts of climate change. Phytoremediation has been widely studied for the remediation of heavy metal stress but it hasn't yet achieved commercial viability in degraded ecosystems of India where it is required the most. Through this review article, we tried to minimize this gap by reviewing some important phytoremediation studies in India which successfully reduced the negative impacts of heavy metals in different degraded ecosystems.

Harmful compared to what? The problem of gaming and ambiguous causal questions.

There has been much concern regarding potential harmful effects of video game-play in the past 40 years, but limited progress in understanding its causal role. This paper discusses the basic requirements for identifying causal effects of video game-play and argues that most research to date has focused upon ambiguous causal questions. Video games and mental health are discussed from the perspective of causal inference with compound exposures; that is, exposures with multiple relevant variants that affect outcomes in different ways. Not only does exposure to video games encompass multiple different factors, but also not playing video games is equally ambiguous. Estimating causal effects of a compound exposure introduces the additional challenge of exposure-version confounding. Without a comparison of well-defined interventions, research investigating the effects of video game-play will be difficult to translate into actionable health interventions. Interventions that target games should be compared with other interventions aimed at improving the same outcomes.

Shifting the gaze from racism to healing from racism: A systematic review of selected psychology journals from 1992 to 2022.

Using a decolonial approach, we provided a narrative review of the research on racism in psychology and conducted a systematic review of the top five psychology journals publishing research on racism and mental health to identify trends in racism research over time and the research gaps. We examined 372 articles on racism published between 1992 and 2022: American Psychologist, Cultural Diversity and Ethnic Minority Psychology, Journal of Black Psychology, Journal of Counseling Psychology, and The Counseling Psychologist. Based on our review, we found that published research examining racism has steadily increased over the past 3 decades, with the greatest spikes in 2021 and 2022. The largest increase was in studies focused on People of Color's experiences with racism. The overwhelming majority of the articles were empirical (86.3%) and most of these studies (87.5%) employed cross-sectional designs. We identified corollary topics by racial/ethnic group, prevalent research designs, and the emergence of strength-based and healing approaches to address racism's impact. There were general racial and ethnic differences in trends, with research on various People of Color groups focused on the harmful effects of racism and research on White populations focused on Whiteness and level of awareness of racism. We conclude with recommendations to enhance the content and methodological rigor of future research while also suggesting policy implications to support advancements in this critical area of study. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Mellisa officinalis Leaf Extract Green-Synthesized AgNPs: Investigation of Its Anaesthetic and Analgesic Activities

Investigating and studying natural origin agents, such as nanocompounds obtained from plants that have less harmful effects, is the main research aim in the field of treatment of diseases. For this goal, extensive research have been performed on several medicinal herbs and their nanoparticles, and their cytotoxic and therapeutic properties have been determined. In the current experiment, the Ag nanoparticles green-synthesis were carried out by the Mellisa officinalis extract. The formulated NPs were analyzed by FESEM, TEM, and UV-Vis. In the in vivo design, after oral administration, paw edema was significantly decreased in mice. CH3COOH-induced writhing episodes were dose-dependently and significantly decreased. The results of anesthetic activity were indicated that the nanoparticles made the local anesthetic effects in guinea pig and frog models. In addition, the analgesic and anti-inflammatory properties were determined in several doses.

Workplace fear of missing out and job burnout: The chain mediating effect of psychological detachment and work–family conflict

We explored the chain mediating role of psychological detachment and work–family conflict in the relationship between workplace fear of missing out (FOMO) and job burnout. Participants comprised 324 Chinese employees who completed online surveys at four time points. Results were as follows: (a) workplace FOMO was negatively correlated with psychological detachment and positively correlated with work–family conflict and job burnout, (b) psychological detachment and work–family conflict played a mediating role in the relationship between workplace FOMO and job burnout, and (c) psychological detachment and work–family conflict played a chain mediating role in the relationship between workplace FOMO and job burnout. The multiple mediating mechanisms by which workplace FOMO affects job burnout point to its harmful effects and indicate a need to reduce its potential impact on job burnout by increasing employees' psychological detachment and reducing their work–family conflict levels.

The impact of polystyrene nanoplastics (PSNPs) on physiological and biochemical parameters of the microalgae Spirulina platensis

Nanoplastics, as emerging pollutants, have harmful effects on living organisms and the environment, the mechanisms and extent of which remain unclear. Microalgae, as one of the most important biological groups in the food chain and sensitive environmental indicators to various pollutants, are considered a suitable option for investigating the effects of nanoplastics. In this study, the effects of polystyrene nanoplastics on the growth rate, dry weight, chlorophyll a and carotenoid levels, proline, and lipid peroxidation in the Spirulina platensis were examined. Three concentrations of 0.1, 1, and 10mgL-1 of PSNPs were used alongside a control sample with zero concentration, with four repetitions in one-liter containers for 20 days under optimal temperature and light conditions. Various analyses, including growth rate, dry weight, proline, chlorophyll a and carotenoid levels, and lipid peroxidation, were performed. The results indicated that exposure to PSNP stress led to a significant decrease in growth rate, dry weight, and chlorophyll a and carotenoid levels compared to the control sample. Furthermore, this stress increased the levels of proline and lipid peroxidation in Spirulina platensis. Morphological analysis via microscopy supported these findings, indicating considerable environmental risks associated with PSNPs. Environmental ImplicationThe research looked into how polystyrene nanoplastics (PSNPs) affect the physiological and biochemical aspects of the Spirulina platensis. Nanoplastics, as pollutants that are becoming more common, can have negative impacts on living organisms and the environment. Since microalgae are crucial parts of the food chain and can act as indicators of pollution in the environment, they were chosen as the focus of this study. Different concentrations of PSNPs 0.1, 1, and 10mgL-1 were used, along with a control group. The results indicated a significant drop in growth rate, dry weight, and chlorophyll levels in the microalgae exposed to PSNPs, while levels of proline and lipid peroxidation increased. These findings suggest a serious potential for environmental damage from PSNPs.

Utilizing magnetic nanoparticles embedded into polyvinyl alcohol and sodium alginate for the absorption of arsenic

Arsenic is an extremely toxic metalloid. The majority of arsenic water pollution originates from industrial activities such as mining, smelting, and utilization of arsenic compounds in glass, pigment, semiconductor, and other industries. Arsenic-containing wastewater poses a threat to groundwater, freshwater, seawater, and soil. Bioaccumulation of arsenic as a result of accidental ingestion may have a harmful effect on the skin and cardiovascular, respiratory, and nervous systems, thereby posing a major health risk. Chemical coagulation, membrane filtration, and adsorption can be used to treat arsenic-containing wastewater. However, chemical coagulation produces a large amount of waste sludge, which is harmful and incurs high processing costs. Membrane filtration is difficult to adopt because of its high operation and maintenance costs. Adsorption is an inexpensive, easy-to-use, sludge-free water treatment method that enables adsorbent recycling. These characteristics make adsorption an economically feasible technique for water treatment. Magnetic nanoparticles (MNPs) are small particles with a high surface area to volume ratio. Their strong magnetic properties enable them to absorb specific water pollutants. MNPs are currently used as water treatment adsorbents. However, they have several drawbacks, including low acid and alkali buffer capacity and water oxidation. In this study, MNPs immobilized with polyvinyl alcohol (PVA) and sodium alginate (SA) were used to enhance the efficacy of wastewater treatment with magnetic materials. These modified MNPs exhibited magnetic characteristics and improved acid resistance. When 100 g/L PVA/SA-MNPs (pH 1–6) were stirred at 120 rpm for 30 min, the resulting iron concentration of the water was 16 mg/L. By contrast, the MNPs released iron in levels ranging from 18 to 4045 mg/L. The PVA/SA–MNPs efficiently adsorbed arsenic in the pH range 3–6, with a high removal efficiency of 76%–82%. At pH 5, the average adsorption capacity was 382 ± 27 μg/g. To recover the MNPs, they were rinsed with deionized water and immersed in acid three times, after which their adsorption capacity was 300 μg/g or higher. By contrast, the PVA/SA-MNPs could be recovered through spontaneous sedimentation, eliminating the need for a magnetic field and simplifying the collection process. In addition, iron dissolution in acidic solutions was minimized for the PVA/SA-MNPs, contributing to environmental protection.

Analysis of landslide susceptibility and potential impacts on infrastructures and settlement areas (a case from the southeastern region of Türkiye)

Landslides have harmful effects not only on buildings but also on infrastructure and the natural environment. While they are typically triggered by natural events, such as heavy rainfalls and earthquakes, landslides can also be induced by anthropogenic activities, such as excavation and blasting. In certain regions, gigantic paleo-landslides exist, but triggering them is extremely difficult. However, triggering secondary landslides in gigantic paleo-landslides is relatively easy compared to the main corpus. The main purpose of this study was to produce a susceptibility map in a region in southeastern Türkiye and to discuss the impact of petroleum seismological investigation concerning the trigger of the landslides. For this purpose, a landslide inventory was compiled using geospatial data sets and field observations and used for landslide susceptibility mapping with the Random Forest algorithm. The accelerations sourced from blasting were also measured and the run-out distances were determined. A run-out distance map was produced using inverse distance weights. The study presents comprehensive insights by integrating a landslide susceptibility map and run-out distance map. It evaluates the impact of blasting on landslides through in-situ measurements and slope stability analyses. Findings indicate that no triggering effect on landslides was observed if the dynamite quantity remains below 4 kg and the blasting distance exceeds 10 m from the landslide.

Bromuconazole exposure induces cardiac dysfunction by upregulating the expression LEF1

With the wide application of bromuconazole (BRO), a kind of triazole fungicide, the environmental problems caused by BRO have been paid more and more attention. In this study, adult male zebrafish were exposed to environmental related concentration and the maximum non-lethal concentration for zebrafish larvae (0,50 ng/L and 7.5 mg/L) for 7 days, respectively. Zebrafish exposed to BRO exhibited a significant reduction in body length and an increase in fatness index, indicating adverse physiological changes. Notably, the exposed zebrafish showed enlarged heart ventricular volumes and thinner heart walls. Transcriptome analysis of heart samples showed that BRO exposure mainly affected pathways related to cardiac energy metabolism. In addition, the amount of ATP in the heart tissue was correspondingly reduced, and the expression levels of genes related to controlling ion balance and myosin synthesis in the heart were also altered. The study extended its findings to the rat cardiomyocytes (H9C2), where similar cardiotoxic effects including changes in transcription of genes related to energy metabolism and heart function were also observed, suggesting a potential universal mechanism of BRO-induced cardiotoxicity. In a doxorubicin (DOX) induced larval zebrafish heart failure model, the expression of lymphoid enhancer-binding factor 1(LEF1), a key gene in the Wnt/β-catenin signaling pathway, was significantly increased in larval zebrafish and adult fish heart tissues and cardiomyocytes, suggesting that LEF1 might play an important role in BRO-induced cardiotoxicity. Taken together, BRO exposure could interfere with cardiac function and metabolic capacity by abnormal activation the expression of LEF1. The study emphasized the urgent need for monitoring and regulating BRO due to its harmful effects on the hearts of aquatic organisms.

Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages

Chlorpyrifos, widely used for pest control, is known to have various harmful effects, although its toxic effects in macrophages and the mechanisms underlying its toxicity remain unclear. The present study investigated the toxic effects of chlorypyrifos in a macrophage cell line. Here, we found that chlorpyrifos induced cytotoxicity and genotoxicity in RAW264.7 macrophages. Moreover, chlorpyrifos induced intracellular ROS production, subsequently leading to lipid peroxidation. Chlorpyrifos reduced the activation of antioxidative enzymes including superoxide dismutase, catalase, and glutathione peroxidase. Chlorpyrifos upregulated HO-1 expression and activated the Keap1-Nrf2 pathway, as indicated by enhanced Nrf2 phosphorylation and Keap1 degradation. Chlorpyrifos exerted effects on the following in a dose-dependent manner: cytotoxicity, genotoxicity, lipid peroxidation, intracellular ROS production, antioxidative enzyme activity reduction, HO-1 expression, Nrf2 phosphorylation, and Keap1 degradation. Notably, N-acetyl-L-cysteine successfully inhibited chlorpyrifos-induced intracellular ROS generation, cytotoxicity, and genotoxicity. Thus, chlorpyrifos may induce cytotoxicity and genotoxicity by promoting intracellular ROS production and suppressing the antioxidative defense system activation in macrophages.

A systematic review on microplastic contamination in marine Crustacea and Mollusca of Asia: Current scenario, concentration, characterization, polymeric risk assessment, and future Prospectives.

Microplastics (MPs) pollution has wreaked havoc on biodiversity and food safety globally. The false ingestion of MPs causes harmful effects on organisms, resulting in a decline in biodiversity. The present review comprehended the current knowledge of MP contamination in Crustacea and Mollusca from 75 peer-reviewed articles published in Asia between 2015 and 2023. A total of 79 species (27 Crustacea and 52 Mollusca) have been recorded to be contaminated with MPs. Out of the total 27 species of Crustacea, Metopograpsus quadridentatus (327.56 MPs/individual) and Balanus albicostatus (0.42 MPs/individual) showed the highest and lowest contamination, respectively. Out of the total 52 species of Mollusca, Dolabella auricularia (2325 MPs/individual) and Crassostrea gigas and Mytilus edulis (0.2 MPs/individual) showed the highest and lowest contamination, respectively. In terms of country-wise MP contamination, China has the highest number of contaminated species in both phylums among Asia. Findings of pollution indices revealed a very high risk of MP contamination in all the countries. Fiber was reported predominantly in both groups. Blue and black-colored MPs having <500 μm and <500 μm-1mm size were found dominantly in Crustacea and Mollusca, respectively. Polypropylene was recorded as the dominant plastic polymer in both Crustacea and Mollusca. In essence, this review has provided a comprehensive insight into MP concentration in Crustacea and Mollusca of Asia, highlighting variations among species and geographic locations. This understanding is crucial for tackling urgent environmental challenges, safeguarding human health, and promoting global sustainability initiatives amid the escalating issue of plastic pollution. PRACTITIONER POINTS: Microplastic pollution has created havoc on biodiversity and food safety. A total of 27 and 52 species of crustaceans and Mollusca have been recorded to be contaminated with MPs. Metopograpsus quadridentate and Dolabella auricularia have shown higher MPs contamination. Polypropylene was recorded as the dominant plastic polymer in both crustacean and Mollusca. Findings of pollution indices revealed a very high risk of MP contamination in all the countries.

In silico predictions of sub-chronic effects: Read-across using metabolic relationships between parents and transformation products

Justifying read-across predictions for subchronic effects, such as no observed adverse effect levels (NOAEL), is challenging. The scarcity of suitable experimental data hampers such predictions, such that a conservative approach is often employed where the structural similarity between target and the tested source substances is very high. A less stringent interpretation of structural similarity may be used to expand data gap-filling by read-across if other types of similarity (e.g., toxicokinetic and toxicodynamic consideration) are factored into the justification. Herein, qualitative and quantitative in silico-assisted procedures are described and demonstrated for those instances where no structurally similar analogues are identified. In the qualitative approach, the toxicity classification of the most toxic metabolite is assigned directly to the target compound. While simple, this approach may lead to an over-classification of the target compound and a false positive result. In contrast, the quantitative approach is more complicated. In addition to identifying those metabolites causing toxicity, it examines the quantitative information for the amount of the most toxic metabolite. The maximum dose of the parent chemical is estimated which will not result in the generation of toxic metabolites sufficient to cause harmful effects. This quantitative approach permits a calculation of the margin of exposure, is noteworthy for industrial assessment purposes.

Effectiveness of lycopene dietary enrichment for growth performance, digestive enzymes, blood health, immunity, and antioxidant status of common carp (Cyprinus carpio) against chronic glyphosate toxicity

For food safety challenges, sustainable aquaculture emerges as a significant source in recent years; however, despite its potential, the industry still facing challenges, notably the exposure of cultured animals to pesticidal pollution. This pollution originating from agricultural practices that can enter aquaculture system directly: to integrated-agriculture aquaculture practices, or indirectly via soil leakage. Current research based on glyphosate (GLY) toxicity and its amelioration by lycopene (LYC). Four fish groups used for six-weeks experiment in which four groups were used. Control group (CL) was fed with basal commercial diet only without any LYC and GLY exposure; 2) LYC group: exposed to LYC supplemented diet (15 mg/kg per fish diet); 3) GLY group: exposed to glyphosate only (1/5th of 96 h LC50: 0.0892 mg/L) with basal commercial diet, and; 4) GLY + LYC group: exposed to both lycopene supplemented diet (15 mg/kg per fish diet) and glyphosate (1/5th of 96 h LC50: 0.0892 mg/L). GLY observed to decrease growth parameters and feed utilization whereas, lycopene ameliorated growth rate (WG, SGR, HSI, CF) and feeding utilization (FCR) as compared to the control group. Also, GLY induced toxicity within hematobiochemical parameters with alleviation by LYC supplementation. GLY induced cytotoxicity was observed within RBCs as lobbing, notching, vacuolation, blebbing, micronuclei, and condensation. Increase in reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS) were observed by GLY exposure. Also, there is observed reduction in antioxidant enzyme activities (CAT, SOD, POD, TPC and GSH) upon GLY exposure. Lipid peroxidation (malondialdehyde: MDA), 8-OHdG (8-hydroxy-2′-deoxyguanosine) and DIY (dityrosine) observed to increase by GLY toxicity. There was improvement in immune responses; increased AChE (acetylcholinesterase) activity, lysozyme content, ACP (acid phosphatase), NBT (nitro blue tetrazolium), NO (nitric oxide) and IgM levels (immunoglobulin M) and digestive enzyme activities (protease, lipase and amylase) observed by LYC supplemented diet. Taken together, LYC supplementation observed to alleviate GLY induced oxidative stress and cytotoxicity with improved immunity, digestive actions and blood health within C. carpio. Therefore, dietary supplementation with lycopene can protect common carp from the harmful effects by glyphosate within agri-integrated aquaculture practices, so suggesting it as potential feed additive.