<sec>The cable harness provides a main gateway for electromagnetic interference(EMI) in electromechanical system. The unreasonable electromagnetic compatibility (EMC) design of cable harness will produce EMI to other on-board electronic equipment, bringing great safety risks to the system. Theoretical research and engineering practice indicate that most of the electromechanical systems cannot satisfy EMC standards, which can be attributed to the EMI generated by cables. As for the eletromagnetic(EM) illumination analysis, reliably and efficiently generating a full numerical model of cable harness is becoming more prominent for the EMC designers. Therefore, it is necessary to develop a more effective method to solve the modeling problem of cable harness. </sec><sec>In the practical application, the cable harness has the characteristics of spatial layout, and its characteristics such as “large number of core wires”, “arbitrary curvature of space” and “randomness of wiring” bring challenges to the modeling of EM coupling to cable harness. The numerical simulation of the whole cable harness model requires severe conditions for computational resource and even makes the EM coupling analysis impossible. Thus, considering the uncertainty of wire position, this paper proposes a generalized simplified modeling method for the EM coupling effect of uncertainty strapping cable harness. Firstly, the Gaussian distribution and spline interpolation are used to determine the location of the core conductors in the random bundling. Then, the distribution parameters of the cable harness at different positions are established by using the transposition relationship between the subsegments of the wires. Finally, the effectiveness of the proposed method is verified by numerical examples of the arc-shaped and sine-shaped harness. </sec><sec>In conclusion, this paper proposes a generalized simplification technique to model the EM illumination on cable harness with uncertainty wiring factors. By grouping the conductors together, the required computation time is markedly reduced and the complexity of modeling the completely cable harness is significantly simplified within a good accuracy. The proposed method provides a way of solving the modeling problem caused by “uncertainty strapping” of the complex wiring harnesses in electromechanical systems.</sec>