Hans Van Research Articles

New Developments in the Cognitive Science of Religion: The Rationality of Religious Belief, by Hans van Eyghen, Rik Peels, and Gijsbert van den Brink

New Developments in the Cognitive Science of Religion: The Rationality of Religious Belief, by Hans van Eyghen, Rik Peels, and Gijsbert van den Brink. Springer. 2018. New Approaches to the Scientific Study of Religion 4. i–vii + 220pp. $139.99. ISBN: 978-3-319-90238-8.

Abstract 6418: Single-cell double expression of MYC and BCL2 proteins by fluorescent multiplex IHC is mainly in lymphoma cells with significant prognostic impact in large B-cell lymphoma while suggesting high cutoffs for routine IHC

Abstract Introduction: MYC+BCL2+ double expression (DE) is a biomarker for poor prognosis in diffuse large B-cell lymphoma (DLBCL), likely due to the cooperation between MYC and BCL2 oncoproteins in tumor cells. However, as generally MYC and BCL2 are separately assessed on two different slides by immunohistochemistry (IHC), MYC+ and BCL2+ results are from different cells. With the WHO-recommended cutoffs, ≥40% for MYC and ≥50% for BCL2 (sum < 100%), there is chance that the so-called DE comes from non-overlapping regions of the tumor (not single-cell DE). Moreover, tumor expression scores based on morphology assessment often vary among pathologists. In this study, we performed fluorescent multiplex IHC (fmIHC) using a MultiOmyxTM immunofluorescence platform (NeoGenomics Laboratories, Inc.) to determine single-cell MYC and BCL2 co-expression for prognostic analysis in DLBCL. Patients and Methods: Co-expression of MYC, BCL2, and 11 immunophenotypic markers by fmIHC was digitally quantified for 547 patients with DLBCL. Percentage of cells with MYC/BCL2 double or single expression was calculated for various cell types. Prognostic analysis was performed for de novo DLBCL cases, including 108 patients treated CHOP chemotherapy, and 356 patients treated with rituximab (R)-CHOP. Results: First, although MYC and BCL2 were expressed in multiple cell types, the vast majority (>90%) of MYC+BCL2+ DE cells were lymphoma cells. Frequencies of MYC and BCL2 co-expression were consistent with random distribution of independent MYC/BCL2 expression in positive cases. The activated B-cell-like subtype compared with the germinal center B-cell-like subtype had a significantly higher mean percentage of MYC+BCL2+ DE, but not single BCL2 or MYC expression, in PAX5+ cells. Second, in both the R-CHOP and CHOP cohorts, high percentages of DE in PAX5+ cells and in all DAPI+ cells were associated with significantly poorer survival of DLBCL patients. Very high percentage of single BCL2 expression in PAX5+ cells was also associated with poorer survival, however, only in a small number of patients in both cohorts. Only in the R-CHOP cohort, high single MYC expression in PAX5+ cells (in a significant proportion of the cohort) was associated with significantly poorer overall survival. In the R-CHOP cohort, eight cases had MYC/BCL2 double hit by FISH, including 3 cases with MYC/IGH fusions (DE) and 5 cases with MYC/non-IGH rearrangements (only one DE). The exclusion of these double hit cases did not impact the significance of DE and single MYC+ expression. Summary: True MYC+BCL2+ double protein expression at the single cell level is predominantly in lymphoma cells, and associated with significantly poor survival of DLBCL patients. Our results suggest high cutoffs for common MYC/BCL2 IHC to identify true double expressor lymphoma. Citation Format: Zijun Yidan Xu-Monette, Yong Li, Qingyan Au, Harry Nunns, Wenyu Shi, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Eric Hsi, Xiaoxian X. Zhao, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Fredrick B. Hagemeister, Andrew Song, Michele Pellegrino, Heounjeong Go, Maurilio Ponzoni, Andrés Ferreri, Michael B. Møller, Benjamin Parsons, J. Han van Krieken, Miguel A. Piris, Jane N. Winter, Mingzhi Zhang, Bing Xu, Ken H. Young. Single-cell double expression of MYC and BCL2 proteins by fluorescent multiplex IHC is mainly in lymphoma cells with significant prognostic impact in large B-cell lymphoma while suggesting high cutoffs for routine IHC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6418.

Correction to: Review of Hans Van Eyghen, The Epistemology of Spirit Beliefs

Correction to: Review of Hans Van Eyghen, The Epistemology of Spirit Beliefs

The Epistemology of Spirit Beliefs, written by Hans Van Eyghen

The Epistemology of Spirit Beliefs, written by Hans Van Eyghen

Paleosols and ancient societies: from early humans to the industrial revolution

Paleopedology, the study of soils developed on ancient landscapes (Yaalon, 1971), was born in Russia through the efforts of Boris B. Polynov (1927), but considering the previous work done by Vasilli V. Dokuchaev in 1883 (Dokuchaev, 1967) and later with the support of Constantin C. Nikiforoff (1943). The Commission on Paleopedology was established in 1965, in Denver, USA, by Dan Yaalon and Hans van Baren (Retallack, 2013) during the 7th Congress of the International Association for Quaternary Research (INQUA) and later, in 1968, the Commission was affiliated to the International Union of Soil Science (IUSS). After the Denver conference, the Commission published a volume with research papers focused on the recognition and classification of paleosols, methods of dating, and soil stratigraphy (Yaalon, 1971). This volume was the beginning of an extensive series of the Commission publications in different special issues of international and national scientific media. Two of these collections were published in open-access Mexican geological journals: Revista Mexicana de Ciencias Geológicas v. 20 no. 3 (2003) and v. 21 no. 1 (2004), and Boletín de la Sociedad Geológica Mexicana, v. 64 no. 1 and 64 no. 2 (2012). The current issue is a continuation of this series. There are two concepts necessary for understanding paleosols. The first is the use of the uniformitarian principle, which suggests that past geologic processes are similar to those acting today on the Earth’s surface. In other words, the basis of modern soil geography and soil genesis is used as directly analogous to reconstruct ancient environments and landscapes. This approach is more precise when applied to Quaternary paleosols and more limited to pre-Cambrian or Paleozoic paleosols, as the environmental conditions under which they were formed are pretty different from the modern ones (Retallack, 2001). The second concept is “soil memory” (Targulian and Goriachkin, 2004), related to a set of properties that can remember ancient environmental conditions. These properties result from pedogenetic processes and soil-forming factors and are time-resistant to environmental changes remaining stable during extended periods (Targulian and Goriachkin, 2004). In recent years, paleopedology has extended its applications to reconstruct past climates, establish variations in the atmospheric composition, trace the ecosystem evolution, and identify geomorphological changes (e.g., Cerling, 1991; Retallack, 1998, 2009; Goudi, 1990; Klinge et al., 2022). Some efforts have also been made to develop models to quantify pedogenetic trends associated with environmental change (e.g., Yaalon, 1975; Sheldon and Tabor, 2009). An essential application of paleopedology has been devoted to solving archaeological problems, as soils can be considered repositories of human activities: agriculture, forestry, material for construction or ceramic production, dwelling and householding (Holliday, 2009; Costa et al., 2021; Yalçın et al., 2021). The impact of past anthropogenic activities has been recorded in the soil memory through time: since the first hunter and gatherers groups to the industrial societies. However, the relationship between humans and their environment (and vice versa) is complex and demands the application of different methodologies and the study of in-site and off-site approaches (Butzer, 2008), which integrates the information directly recovered in the archaeological excavation and that from the surrounding areas. In this sense, the paleosol-archaeological investigation has a more solid interpretation. In June 2021, the Paleopedology Commission of the IUSS, the Paleopedology Working Group of the INQUA, and the Institute of Geology of the UNAM organized a three-day online meeting with scientific sessions. The meeting topics related to the link between paleosols, the history of human interactions, and the environment. This special issue was launched as a result of this meeting. The articles included here aim to improve our understanding of the materials used for ancient constructions also past human interactions with the environment.

SCIENCE, RELIGION, AND CULTURE

SCIENCE, RELIGION, AND CULTURE

Spirit Tech: The Brave New World of Conscious Hacking and Enlightenment Engineering. BWesley J. Wildman and Kate J. Stockly. New York:Macmillan. 395 pp. $29.99. (Hardcover).

Zygon®Volume 57, Issue 4 p. 1141-1142 Reviews Spirit Tech: The Brave New World of Conscious Hacking and Enlightenment Engineering. B Wesley Wildman and Kate Stockly. New York:Macmillan. 395 pp. $29.99. (Hardcover). Hans Van Eyghen, Hans Van Eyghen orcid.org/0000-0002-2971-554X Tilburg University, The NetherlandsSearch for more papers by this author Hans Van Eyghen, Hans Van Eyghen orcid.org/0000-0002-2971-554X Tilburg University, The NetherlandsSearch for more papers by this author First published: 02 November 2022 https://doi.org/10.1111/zygo.12853Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Volume57, Issue4December 2022Pages 1141-1142 RelatedInformation

Enemy within the gates: militarism, sabotage, subversion and counter-subversion in South Africa, 1939-1945

ABSTRACT In September 1939, when the Union of South Africa entered what became the Second World War, the country was confronted with wide-spread political dissent and anti-war resistance which threatened internal security and stability. Incidents of violence, sabotage, riots, bomb explosions, cutting of tele-communication lines and constant militarism designed to thwart the country’s war effort were reported. These incidents were perpetuated by the disaffected radical Afrikaner nationalists who opposed the Union’s war policy, particularly the militant Ossewabrandwag (OB) led by Dr Johannes Frederik Janse (Hans) van Rensburg, in collaboration with Nazi espionage agents. The government of General Jan Christiaan Smuts implemented multi-faceted security arrangements, which included passing the War Measures Act, unleashing the security services and adopting the internment policy to subdue the militants and preserve internal security. This article examines the development of anti-war resistance and militarism in the Union and reflects on the counter-subversive efforts by the Smuts government to preserve internal security during the Second World War. Ultimately, given the magnitude of the anti-war destabilisation campaign, this analysis illustrates how and why the Smuts government survived a two-front war and managed to sustain the war effort.

How Should Theists Respond to Debunking Arguments? A Critique of Hans Van Eyghen’s Arguing from Cognitive Science of Religion

Abstract Cognitive science of religion has inspired several debunking arguments against theistic belief. Hans Van Eyghen’s book Arguing from Cognitive Science of Religion is the first monograph devoted to answering such arguments. This article focuses on Van Eyghen’s responses to two widely discussed debunking arguments, one by Matthew Braddock and another by John Wilkins and Paul Griffiths. Both responses have potential but also face problems. Even if Van Eyghen manages to show that these authors have not fully excluded the possibility of noninferential theistic belief being underpinned by reliable belief-forming processes, he fails to offer convincing reasons to think the processes are in fact reliable. A positive argument for their reliability might ultimately have to be based on evidence for God’s existence, namely, theistic arguments. The question of the rationality of religious belief (de jure) thus cannot be isolated from the question of God’s existence (de facto).

Architectural Proportion from an Empirical Standpoint

Proportion has long been central to theories of design and architecture before its role was questioned in the mid–twentieth century. In spite of this scrutiny, no definitive conclusion has been reached on the question of how proportion affects experience of the built environment. Here, an architect and a scientist attack this question from an empirical standpoint. They argue that, as a starting point, it is important to understand under which conditions proportions are perceptible by the flesh–and–blood person who moves freely through the built environment and observes it under various distances and angles. The authors begin by surveying the work of two forerunners of empirical study of proportion: The Russian architect and educator Nikolai Ladovsky, whose “psychotechnical” approach was inspired by scientific psychology, and the Dutch architect Hans van der Laan, who developed the theory of plastic number concerned with proportions of three–dimensional objects, and whose approach was strikingly similar to scientific approaches. Following an analysis of informal studies by Ladovsky and Van der Laan, the authors examine implications of such studies for education in architecture and interior design, and then describe two approaches to investigating architectural proportion formally, by methods of sensory psychophysics.

Manhua Modernity: Chinese Culture and the Pictorial Turn

Manhua Modernity: Chinese Culture and the Pictorial Turn

The Private Side of Transforming our World. UN Sustainable Development Goals 2030 and the Role of Private International Law. Ed. by Ralf Michaels, Veronica Ruiz Abou-Nigm, Hans van Loon. Project Coord

The Private Side of Transforming our World. UN Sustainable Development Goals 2030 and the Role of Private International Law. Ed. by Ralf Michaels, Veronica Ruiz Abou-Nigm, Hans van Loon. Project Coord, 10.1628/rabelsz-2022-0085, Jahrgang 86 (2022) / Heft 4, 0033-7250 (1868-7059), The Rabel Journal of Comparative and International Private Law

ANALISIS STRATEGI AKTUALISASI DIRI SASYA TRANGGONO PEREMPUAN PERUPA INDONESIA DALAM MASA PANDEMIK COVID-19

Sasya Tranggono is an Indonesian female artist who works with the subjects of puppets, flowers and butterflies. Her work is well known in the Indonesian art social scenes; she has actualized herself. In this research condition analyzes the self-actualization process during the Covid-19 pandemic. This research is a qualitative research. Using Abraham Maslow's theory of self-actualization which has been converted to fine arts, Hans Van Maneen's theory for the exhibition process, and Hennessy's theory relating to publication on social media. Based on the analysis, it can be seen that Sasya Tranggono tries to maintain her self-actualization even through social media such as Instagram and the web. She has collaborated with several galleries to exhibit her work online and offline. All of her publication strategies kept her at the pinnacle of self-actualization.

ANALISIS STRATEGI AKTUALISASI DIRI SASYA TRANGGONO PEREMPUAN PERUPA INDONESIA DALAM MASA PANDEMIK COVID-19

Sasya Tranggono is an Indonesian female artist who works with the subjects of puppets, flowers and butterflies. Her work is well known in the Indonesian art social scenes; she has actualized herself. In this research condition analyzes the self-actualization process during the Covid-19 pandemic. This research is a qualitative research. Using Abraham Maslow's theory of self-actualization which has been converted to fine arts, Hans Van Maneen's theory for the exhibition process, and Hennessy's theory relating to publication on social media. Based on the analysis, it can be seen that Sasya Tranggono tries to maintain her self-actualization even through social media such as Instagram and the web. She has collaborated with several galleries to exhibit her work online and offline. All of her publication strategies kept her at the pinnacle of self-actualization.

Intranodal Lymphangiography With High-Dose Ethiodized Oil Shows Efficient Results in Patients With Refractory, High-Output Postsurgical Chylothorax: A Retrospective Study.

OBJECTIVE. The purpose of this study is to evaluate the safety and efficacy of intranodal lymphangiography (INL) with high-dose ethiodized oil in patients with postoperative refractory chylothorax. MATERIALS AND METHODS. A retrospective review of a cohort of 18 patients with refractory postoperative chylothorax seen between May 2015 and March 2019 was conducted. All patients underwent intranodal lymphangiography with high doses of ethiodized oil (mean, 75 mL; range, 40-140 mL). The following information was gathered from the institutional database: patient demographics, type of surgery, output volumes, interval between surgery and lymphangiography, imaging results, amount of ethiodized oil injected, clinical success, and time to resolution. RESULTS. Of the 18 patients, 11 (61%) had previously undergone thoracic duct ligation, and seven (39%) had not. A lymphatic leak was confirmed by lymphangiography in 12 of 18 patients (67%). A total of five patients underwent a second session of INL, which was successful in three of the patients (60%). Removal of all chest tubes was possible in 15 of 18 patients (83%) after a mean of 12 days (range, 1-25 days). Two patients had an anastomotic leak develop after esophagectomy and died with their chest tubes in situ. One patient underwent thoracic duct ligation after two failed INL procedures. No complications were recorded. CONCLUSION. INL with a high dose of injected ethiodized oil is a safe and effective procedure for the management of postsurgical refractory chylothorax, with chest tube removal in 83% of patients.

Tax Treaties and Abuse: The Effectiveness of the Principal Purpose Test and Some of Its Shortcomings

In this article, Hans van den Hurk sets out his views on the abuse of tax treaties and the effectiveness of the provisions contained in article 29(9) of the OECD Model regarding the principal purpose test (PPT), together with a consideration of some of the drawbacks of the PPT.

Revisiting the plastic number theory from the perspective of perceptual psychology

Architect Hans van der Laan spent his lifetime studying human perception of proportion. His work led to the development of the plastic number system. In this system every step represents a group of fractions that describe objects of similar sizes. Indeed, each step is defined as the ‘representative size’ of a group of sizes that are perceptually indiscriminate from one another. Over decades of research, Van der Laan conducted a series of experiments to test his system. The clarity with which he approached the perception of proportion provides a suitable ground for testing the plastic number by scientific means. To take the first step in that direction, it is useful to consider Van der Laan’s approach within the context of sensory psychophysics and Gestalt psychology. Highlighting these connections suggests specific directions for future research of the plastic number and opens a new chapter in studies on proportion in architecture.

Political Liberalism and Respect*

Journal of Political PhilosophyVolume 29, Issue 3 p. 353-374 Original Article Political Liberalism and Respect* Han van Wietmarschen, Han van Wietmarschen Philosophy, University College LondonSearch for more papers by this author Han van Wietmarschen, Han van Wietmarschen Philosophy, University College LondonSearch for more papers by this author First published: 15 December 2020 https://doi.org/10.1111/jopp.12240Citations: 1 *Thanks to R. J. Leland for many years of figuring out political liberalism together, and to Jonas Vandieken for helpful conversations about respect for persons. Thanks also to audience members at the University of Glasgow and workshop participants at MANCEPT for raising important questions and objections to earlier drafts of this article. Christian Barry and two anonymous referees for this journal provided comments that led to significant improvements as well. Lauren van Wietmarschen helped dot the i’s and cross the t’s. This work was supported by the Leverhulme Trust (grant number RF-2018-377\10). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume29, Issue3September 2021Pages 353-374 RelatedInformation

A distinctness approach to clitic combinations in Romance

AbstractThis paper analyses the combinatorial restrictions that operate in clitic clusters in certain Eastern Iberian varieties (Aragonese, Spanish, and Catalan). In particular, I focus on the combination of third person clitics. As it is well known, in some Romance varieties the combination of a third person accusative clitic and a third person dative clitic is banned (the so-called∗le lorestriction, Bonet, Eulàlia. 1991.Morphology after syntax: Pronominal clitics in Romance. Cambridge: Massachusetts Institute of Technology Dissertation; Cuervo, María Cristina. 2013. Spanish clitic clusters: Three of a perfect pair.Borealis: An International Journal of Hispanic Linguistics2. 191–220; Nevins, Andrew. 2007. The representation of third person and its consequences for person-case effects.Natural Language & Linguistic Theory25(2). 273–313; Ordóñez, Francisco. 2002. Some clitic combinations in the syntax of Romance.Catalan Journal of Linguistics1. 201–224, Ordóñez, Francisco. 2012. Clitics in Spanish. In José I. Hualde, Antxon Olarrea & Erin O’Rouke (eds.),The handbook of Spanish Linguistics, 423–453. Malden: Wiley-Blackwell; Perlmutter, David. 1971.Deep and surface structure constraints in syntax. New York: Holt, Rinehart & Winston). In order to license this troublesome combination, languages resort to different ‘repair strategies’ modifying the structure of one of the merged clitics. In the literature on clitic combinations, there have been two main proposals of analysis: morphological and syntactical. In this paper, I put forward an analysis based on the Distinctness Condition (Hiraiwa, Ken. 2010. The syntactic OCP. In Yukio Otsu (ed.),The proceedings of the 11th Tokyo Conference on Psycholinguistics, 35–56. Hituzi: Tokyo; Neeleman, Ad & Hans van de Koot. 2005. Syntactic haplology. In Martin Everaert & Henk van Riemsdijk (eds.),The Blackwell companion to syntax, 685–710. Wiley-Blackwell; Perlmutter, David. 1971.Deep and surface structure constraints in syntax. New York: Holt, Rinehart & Winston; Richards, Norvin. 2010.Uttering trees, vol. 56. Cambridge, MA: MIT Press; Van Riemsdijk, Henk. 1998. Categorial feature magnetism: The endocentricity and distribution of projections.The Journal of Comparative Germanic Linguistics2(1). 1–48; Yip, Moira. 1998. Identity avoxidance in phonology and morphology. In Steven G. Lapointe, Diane K. Brentari & Patrick M. Farell (eds.),Mophology and its relation to phonology and syntax, 216–246. Stanford, CA: CSLI). Specifically, I argue that the restrictions that constraint clitic combinations are due to the impossibility to linearize two identical syntactic objects, such as <XP, XP> (Chomsky, Noam. 2013. Problems of projection.Lingua130. 33–49; Chomsky, Noam. 2015. Problems of projection. In Elisa Di Domenico, Cornelia Hamann & Simona Matteini (eds.), Structures, strategies and beyond: Studies in honour of Adriana Belletti, 1–16. Amsterdam: John Benjamins; Moro, Andrea. 2000.Dynamic antisymmetry (No. 38). Cambridge, MA: MIT Press; Richards, Norvin. 2010.Uttering trees, vol. 56. Cambridge, MA: MIT Press). From this perspective, cross-linguistic variation is the result of different ‘repair strategies’ languages deploy to make <XP, XP> objects linearizable (Richards, Norvin. 2010.Uttering trees, vol. 56. Cambridge, MA: MIT Press).

Abstract 5163: A colon cancer survivor-derived antibody recognizes a previously unidentified truncated, O-mannosylated 70kDa variant of E-cadherin

Abstract INTRODUCTION Colorectal cancer (CRC) associated with Lynch syndrome is characterized by an abundance of infiltrating lymphocytes. To study whether tumor-specific antibodies with therapeutic potential can be isolated from these patients, the B-cell repertoire from a patient with Lynch syndrome who recovered from a stage IV colon carcinoma was screened. Here we describe a novel human antibody, AT1636 that recognizes a previously unidentified O-mannosylated 70kDa form of E-cadherin. The intercellular interactions by E-cadherin on tumor cells have for long been recognized as protective in cancer metastasis, and deregulation of E-cadherin is a hallmark for epithelial-mesenchymal transition (EMT). METHODS AIMM's BCL6 and Bcl-xL immortalization method[1] was used to interrogate the human antibody repertoire against targets on colon cancer cells. From a carrier of a pathogenic gene variant in the MSH6 gene diagnosed with stage IV CRC and liver metastasis that had been treated with avastin, capecitabine and oxaliplatin, peripheral-blood memory B cells were obtained 9 years after last treatment. Antibodies-containing supernatant of cultured B-cells were screened for binding to 3 different CRC cell lines (DLD1, LS174T and COLO205) and absence of binding to fibroblast by flow cytometry. High-affinity variants of AT1636 (AT1636IYN) were sorted from the AID-expressing immortalized B-cells clone[2]. RESULTS Patient derived antibodies that demonstrated differential binding to CRC cells were further characterized. Targets recognized by such antibodies were identified using immunoprecipitation and mass-spectrometry. AT1636 binds to a previously unidentified single O-mannosylated 70kDa E-cadherin variant (ECV). Although the 70 kDa ECV is found in all cells that express full length E-cadherin, tumor-specific binding of AT1636 is dependent on the single O-mannosylation pattern in the antibody epitope on ECV. Using shRNA knock-down AT1636 binding was shown to depend on the transmembrane O-mannosyltransferase targeting cadherins 3 (TMTC3)[3]. In accordance, coexpression of TMTC3 and E-cadherin in tumor cells is predictive for AT1636 binding. In addition, we observed that (over)expression of ECV results in a strong de-adhesive, EMT-like phenotype. Although AT1636 by itself is not able to induce ADCC, the CD3-bispecific antibody (single-chain UCHT1) AT1636 format specifically killed CRC cell lines. CONCLUSION The AT1636 antibody retrieved from a patient with Lynch syndrome binds a previous unidentified cancer-specific O-mannosylated 70kDa form of E-cadherin. This variant might play a role in tumor-cell invasion and metastasis. More importantly, we provide a rationale to advance AT1636 based therapeutics for treatment of CRC. references 1) Kwakkenbos et al. Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming. Nature Medicine 2010 2) Wagner et al. Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity. PNAS 2014 3) Larsen et al. Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. PNAS 2017 Citation Format: Martijn Kedde, Tim Beaumont, Sabrina J. Merat, Mark J. Kwakkenbos, Lina Bartels, Dorien van de Berg, Koen Wagner, Arjen Q. Bakker, Kelly Maijoor, Martino Böhne, Camille Bru, Veronika Kattler, Hans van Eenennaam, Victorine H. Roos, Frank G.J. Kallenberg, Jan Paul Medema, Paul J. Hensbergen, Pauline van Helden, Evelien Dekker, Hergen Spits. A colon cancer survivor-derived antibody recognizes a previously unidentified truncated, O-mannosylated 70kDa variant of E-cadherin [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5163.