Objective To design a novel transpedicular lag-screw for the treatment of Hangman's fracture.Methods Twenty adult dried cervical vertebrae specimens were selected and used vernier caliper to measure the indexes of C2,including the height of pedicle,the width of pedicle,the distance of massa lateralis midpoint (entry point) to anterior vertebral,and the anteroposterior diameter of processus articulares superiores.The X-ray films of six Hangman's fracture patients after reduction were selected,and the indexes of C2 were measured on computer,including the distance of entry point to anterior edge,the distance of entry point to fracture line,and the distance of fracture line to anterior edge.According to the anatomic parameters of C2 pedicle and the characteristics of Herbert-screw,a new type of transpedicular lag-screw was designed,which is more suitable for the treatment of Hangman's fracture.This screw is double-threaded,and the biomechanics of which were compared with ordinary ones.Results Specimen measurements showed the height of pedicle (7.40±1.04) mm,the width of pedicle (7.45±1.54) mm,the distance of massa lateralis midpoint to anterior vertebrae (27.95±1.69) mm,and the anteroposterior diameter of processus articulares superiors (17.29±1.51) mm.X-ray measurements showed the distance of entry point to anterior edge (29.19±3.54) mm,the distance of entry point to fracture line (10.71±2.44) mm,and the distance of fracture line to anterior edge (15.35±1.66) mm.There were no significant differences between the two sides of the pedicle measurements.The new-screw group and the ordinaryscrew group tensile strength was (2266.47±158.82) N and (1715.51±69.99) N,respectively.There were statistically significant differences between the two groups.Conclusion The effect of novel transpedicular lag-screws for the treatment of Hangman's fracture is better than that of the ordinary ones. Key words: Axis; Spinal Fractures; Internal Fixators; Biomechanics