The NW-dipping Fiery Creek Fault System, located in the northern Mount Isa terrane, comprises numerous sub-parallel faults that record multiple episodes of Palaeo- to Mesoproterozoic movement. Hanging wall wedge-shaped stratal geometries and marked stratal thickness variation across the fault system indicate that the earliest movement occurred during episodic intracontinental extension (Mount Isa Rift Event; ca. 1710–1655Ma). Reactivation of the fault system during regional shortening and basin inversion associated with the Mesoproterozoic Isan Orogeny (ca. 1590–1500Ma) resulted in complex three-dimensional hanging wall geometries and highly variable strain in the hanging wall strata along the fault system. This has resulted in the development of discrete hanging wall deformation compartments, that are characterised by different structural styles. High strain compartments are characterised by relatively intense folding and the development of break-back thrusts, whereas low strain compartments are only weakly folded. Variations in hanging wall strain are attributed to selective reactivation of normal fault segments, controlled by the pre-inversion fault dip and lithological contrasts across the faults. Variation of the pre-inversion fault dip is interpreted to have been caused by episodic tilt-block rotation during crustal extension. Moderately dipping faults active early in the Mount Isa Rift Event show the greatest degree of reactivation, whereas younger and steeper normal faults have behaved as buttresses during inversion with strain focussed in zones of upright folding in the hanging wall.