Suspension system is one of the key parts of vehicle, the performance of suspension system has great influence on vehicle handling stability and safety. In order to improve the performance of suspension system, the Macpherson suspension of a vehicle is taken as the research object, the suspension model is established by ADAMS/Car, and carried out parallel wheel travel simulation to analyze the key parameters variation of camber angle, toe angle, caster angle, kingpin inclination angle and scrub radius. Simulation results show that camber angle and scrub radius are beyond normal design range and require optimization. Wheel alignment parameters are determined by sensitivity analysis, and optimized by ADAMS/Insight. Then carried out simulation to analyze the performance of optimized suspension system. Results show that optimized suspension system satisfies the requirements of vehicle stability and safety.