The wheeled chassis, which is the carrying device of the existing handling robot, is mostly only suitable for flat indoor environments and does not have the ability to work on outdoor rugged terrain, greatly limiting the development of chassis driven handling robots. On this basis, this paper innovatively designs a four-wheel-driving Ackerman chassis with strong vibration absorption and obstacle surmounting capabilities and conducts performance research and optimization on it through quantitative experiments and dynamic simulation. Firstly, based on the introduction of the working principle and structure of the four-wheel-driving Ackerman carrier chassis, a multi-sensor distributed dynamic performance test system is constructed through the analysis of the chassis performance evaluation index. Then, according to the quantitative operation experiment of the chassis, the vibration and acceleration characteristics of the chassis at different positions of the chassis, the amount of slip and straightness of the chassis under different running distance, and the operating characteristics of the chassis under different road conditions and different damping springs conditions were analyzed respectively, which verified the rationality of the chassis design. Finally, by constructing the chassis dynamics simulation model; the influence law of chassis structure; and performance parameters such as chassis wheelbase, guide rod structure, and parameters, wheel friction coefficient and assembly error on the dynamic characteristics of the chassis is studied, and the optimal structure of the four-wheel-driving Ackerman chassis is determined while it is verified based on the simulation results. The research shows that the four-wheel-driving Ackerman chassis has good vibration performance and stability and has strong adaptability to different roads. After optimization, the vibration performance, stability, amount of slip, and straightness of the chassis structure are significantly improved, and the straightness is reduced to 0.399%, which is suitable for precise carriage applications on the chassis. The research has important guiding significance for promoting the development and application of wheeled chassis.