Hairdressers are exposed to awkward posture, prolonged standing, long working hours and chemical hazards capable of causing adverse health effects. The present study aimed to evaluate hairdressers' safety and health risks. The study adopted a descriptive cross-sectional and analytical design. Systematic random sampling was used to select salons and hairdressers. Closed and open-ended questionnaires were distributed to 286 hairdressers who consented to participate in the study. An observation checklist, WISHA caution checklist, thermometer, light meter and noise level meter were used to collect data in the sampled salon. Data were analyzed descriptively and with regression analysis. It was found that the average space for salons was 8.79 m2, and 68.5% of hairdressers work for long hours (11-12 hours). It was established that 5.48% of salons have an adequate amount of light and that 8.22% of salons have high temperatures. Aprons were the most used personal protective equipment by hairdressers. Manual handling of salon equipment and awkward posture cause musculoskeletal disorders among hairdressers. Their odd ratios impacting the health and safety of hairdressers were 2.706 and 2.728, respectively. The study reveals that hairdressing salon designs, space, lighting, and temperatures affect the health and safety of hairdressers. The hours off work and minimal or no breaks also have negative impacts on the health and safety of hairdressers