Late order loss for difficulty handling (loading and unloading) activities left an alarm message to make traditional transportation handling for distribution e-commerce more accessible through mitigating it to semi-auto actions. This article discusses the idea of Vehicle Containers made up of Permutational Drawers, i.e., VCPD, that ensure ergonomic handling. The proposed Ergonomic Digital Twin (EDT) manages the VCPD by the Internet of things, i.e., IoT. The VCPD object has two dimensions: drawers' size and motion mechanism. These targets are implemented via establishing the digital twins' model, i.e., DT, for these drawers to test its qualifying for implementation, mainly if supported by IoT. There is still much confusion regarding the DT and how it will apply to the VCPD in medium-sized schemes for transportation enterprises. This work activates the IoT to bolster and simplify transportation activities through designing VCPD and control via a unified framework having several standard steps to reduce execution time, effort, and transportation costs.