Patients who have chronic renal failure, one of the therapies that can be done to prolong his life is hemodialysis. A phenomenon found in the room of hemodialysis at Awal Bros Panam hospital, most of the patients undergoing hemodialysis experienced muscle weakness, muscle atrophy, and pain in standing after hemodialysis. This study was aimed to determine the effect of physical exercises during hemodialysis towards strength patients with chronic kidney failure on hemodialysis room at Awal Bros Panam hospital. Moreover, this research employed Quasi-Experiment method with time series design. The sample of this study was patients who underwenthemodialysis included in the inclusion criteria of 45 people. Physical exercise was done with time 45 minutes, 2 times a week according to hemodialysis schedule for 4 weeks or 8 times physical exercise. Expanding Dynamometer and Back Leg Dynamometer were used as the measuring instruments. The analysis that used was univariate analysis to figure out frequency and bivariate with Paired sample t -test and Wilxocon. The results showed there was an effect of physical exercise on hand muscle strength of 2.76 kg and an effect of physical exercise on leg muscle strength of 13.5 kg. Also, The results of statistical tests showed the effect of physical exercise on hand and foot muscle strength in hemodialysis patients with p-value 0.001 <α (0.05). In other words, these results indicated that physical exercise can improve muscle strength of patients undergoing hemodialysis. Regarding the research findings, Educationalinstitutions and services need to hold discussions in the development of nursing actions during hemodialysis because physical exercise during hemodialysis is still a novelty.