Han Control Groups Research Articles

Analysis of the Correlation between FH and PCSK9 and APOB Gene Mutations in Han and Mongolian Populations of the Hulunbuir.

The goal of the study was to provide an individual and precise genetic and molecular biological basis for the early prevention, diagnosis, and treatment of local FH by analyzing the risk factors for the development of FH in Han and Mongolian patients in the Hulunbuir, comparing the lipid levels of FH patients of the two ethnicities, and assessing differences in mutations to two genes between the two ethnic groups. Twenty cases each of Han Chinese and Mongolian healthy controls and fifty patients who each met the inclusion criteria from November 2021 to December 2022 in five general hospitals in Hulunbuir were selected. Multifactor logistic analysis was used to analyze the risk factors associated with the development of FH. We used t-tests to analyze statistical differences in lipid levels between the groups, and Sanger sequencing to detect the dis-tribution of common mutation sites of PCSK9 and APOB in all study subjects. The mutation rates and differences between regions and ethnic groups were summarized and compared. 1) Gender, age, alcohol consumption, dietary status, and a family history of FH were risk factors associated with the development of FH. 2) TC, LDL-C, and APOB were significantly higher in Mongolian cases than Han cases (p < 0.05). sdLDL-C was not statistically different between the two ethnicities (p > 0.05). 3) We detected four (8%) heterozygous mutations at the PCSK9 gene E670G mutation site in the Han case group and a total of nine (18%) mutations at this site in the Mongolian cases, including one (2%) homozygous and eight (16%) heterozygous mutations. One case of a heterozygous mutation was detected in the Mongolian control group. We detected a total of ten (20%) mutations at the APOB gene rs1367117 mutation site in the Han case group, including eight (16%) heterozygous and two (4%) homozygous mutations, 11 cases (22%) of heterozygous mutations in the Mongolian case group, two cases of heterozygous mutations in the Han control group, and one case of a heterozygous mutation in the Mongolian control group. 4) The D374Y and S127R mutation sites of PCSK9 and the R3500Q mutation site of APOB were not detected in any of the study subjects. The mutation sites of the PCSK9 and APOB genes in FH patients in Hulunbuir are different from other regions, and the mutation rate is higher than in other regions. Therefore, we recommend that the mutation sites of the PCSK9 and APOB genes described herein be used as clinical detection indicators to assist the diagnosis of FH in this region.

Analysis of serum rheumatoid factors in patients with rheumatoid arthritis in Han, Tibetan and Hui nationalities in Qinghai

ObjectiveThe aim of this study was to compare the sensitivities, specificities and correlations of serum rheumatoid factors across different races in RA patients. MethodsSerum rheumatoid factors were tested in 150 subjects who were divided into 3 groups: group 1 including 25 Han RA patients (Han-RA) and 25 healthy Han control groups, group 2 including 25 Tibetan RA patients (T-RA) and 25 the healthy Tibetan control group and group 3 including 25 Hui-RA patients (Hui-RA) and 25 Hui healthy controls. ResultsThere were significant differences in ESR, A-CCP, CRP, RF, SAA, SFe, IL-4, IL-6, IL-10 and IL-17 between RA patients and the corresponding control subjects in all 3 groups (P < 0.01 for ESR, A-CCP, CRP, RF, IL-4, IL-6, IL-10 and IL-17, P < 0.05 for SAA and SFe). In Tibetan RA, the levels of A-CCP were significantly lower than the Han-RA and Hui-RA. SAA of T-RA was significantly lower than the Han-RA (P < 0.05). ConclusionESR, CRP, RF, A-CCP, SAA, SFe and IL serum rheumatoid factors were useful biomarkers for RA detection in all three races.

HLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, China.

This study aims to investigate the distribution of HLA-A genes and identify alleles related to cervical cancer. A total of 252 cervical cancer patients (56 Han ethnic and 196 Uyghur ethnic) and 213 controls (103 Han ethnic and 110 Uyghur ethnic) were recruited in this study. HLA-A alleles were examined by polymerase chain reaction with sequence-specific primers. The frequencies of different HLA-A alleles were compared between the two ethnic groups as well as patients and controls. The correlation of HLA-A frequencies with various clinical characteristics and short-term treatment efficacy was analyzed. (1) Significantly higher frequencies of HLA-A*03:01 and HLA-A*03:02 and lower frequencies of HLA-A*11:01, HLA-A*24:02, and HLA-A*30:01 were observed in the Uyghur control groups than in Han control groups (P ≤ 0.05). (2) The frequency of HLA-A*01:01 in patients was significantly higher than controls. In contrast, the frequencies of HLA-A*30:01 and HLA-A*33:03 were lower in patients (P ≤ 0.05). (3) The frequency of HLA-A*30:01 in Han patients was lower than Han control group (P ≤ 0.05). However, there was no statistically significant in the frequency of HLA-A between Uyghur patients and controls (P > 0.05). (4) There was no significant association between HLA-A alleles and HPV16 or squamous cell carcinoma antigen levels (P > 0.05). (5) The frequency of HLA-A*30:01 allele in complete response + partial response group was higher than stable disease + progressive disease group (P ≤ 0.05). People from two ethnic groups displayed different HLA-A gene distribution. HLA-A*30:01 and HLA-A*33:03 alleles are the protective factors to cervical cancer patients from Xinjiang while HLA-A*01:01 serves as the susceptible gene.

Comparative analysis of platelet 5-HT concentrations in Han and Li patients with post-traumatic stress disorder.

We investigated the role of serotonin (5-HT) in the pathogenesis of post-traumatic stress disorder (PTSD) by determining the platelet 5-HT concentrations in Li and Han patients with PTSD in Hainan Province, China. Li and Han control groups of the same sample size have no statistical differences in gender and age distribution compared to those in the PTSD groups who were also examined. The platelet 5-HT concentrations were determined by high-performance liquid chromatography. In addition, the patients and controls were evaluated by the impact of event scale-revised (IES-R). IES-R showed that the total and sub-scale scores of three factors (avoidance, intrusion, and hyperarousal) of Li patients with PTSD were significantly higher than those of Han patients with PTSD. Scores of both PTSD groups were higher than those of their respective control groups. The platelet 5-HT concentration of the Li patients with PTSD (120.56 ± 118.05 ng/10(9) platelets) was lower than that of the Han patients with PTSD (271.43 ± 181.66 ng/10(9) platelets) and that of both Li and Han control groups (338.54 ± 156.46, 350.58 ± 169.19 ng/10(9) platelets, respectively). Differences existed in symptoms of PTSD in terms of avoidance, intrusion, and hyperarousal in the Li and Han patients with PTSD. The diminished 5-HT activity in patients with PTSD may be relevant to biochemical changes in the brain and body. The differences in these factors between ethnic groups could be due to their customs, social status, and culture.

Personality of Han and Uygur patients with depression: a multi-dimensional comparative study

Objective To compare the differences of personality in patients with depression between Uighurs and Han Chinese. Method Hospitalized depressed patients were selected including 44 cases of Uygur people, 73 cases of Han people and Han people with normal control 41 cases. Using Minnesota Multiphasic Per-sonality Inventory(MMPI), Eysenck Personality Questionnai(EPQ)and Cattell's 16 Personality Factor (16PF) to make the survey. Results In MMPI : Uighur depression group's factors F, Hs, D, Hy, Pt, Pa and Sc's T score were all higher than 70, and Han depression group's factors Hs, D, Hy, and T score of Pa were all higher than 70. Only F (76.98±16.01 vs 67.16±13.51, P 0.05). And Han depression group compared with the Han control group, four scales were statistically significant differences (P 0.05). Comparing Han depression group with Han normal control group, the factors of gregariousness A, stability C, excitability D, perseverance G, boldness H, sensitivity I, skeptical L, anxiety and O, self-discipline Q3, tension Q4 (P 0.05). Conclusion The personality model of depression between the Uygur and Han nationality has the consistency of national culture, and differences with normal people. Prompt Uygur and han depression may have a common characteristic of pathological personality model. Uighur and han ethnic differences in national culture and personality is the character of diversity, is not a Uighur and Han the pathological basis of personality of depression. Key words: National; Depression; Personality

Association of sex hormones with risk of coronary heart disease in postmenopausal women of Hans and Uygurs

Objective To explore the association between serum sex hormones and the risk of coronary heart disease (CHD) in postmenopausal women of Hans and Uygurs in Xinjiang.Methods Postmenopausal women were selected during January 2006 to February 2012 from cardiology center of the First Affiliated Hospital of Xinjiang Medical University.They were assigned to Uygur case group (n =138),Uygur control group (n =141),Han case group(n =138),and Han control group (n =151).Blood samples were collected to determine total testosterone,estradiol,aromatase,fasting glucose,and lipid profile.Results Postmenopausal women of Han with CHD had lower estradiol(P＜0.05) and higher total testosterone (P＜0.05) than those in the controls.Multiple Logistic regression revealed that serum estradiol was independent protective factors for CHD (OR =0.94,P ＜ 0.01),and total testosterone were independent influencing factors for CHD (OR =6.43,P＜0.05).Postmenopausal women of Uyghur with CHD had lower estradiol (P＜0.05) and slightly higher serum total testosterone (P＞0.05) than those of control group.After adjusting confounding factors,high level of serum estradiol was an independent protective factor for CHD (OR=0.94,P＜0.01).In quantitatively adjusted models,Q4 vs Q3 in Hans(OR =3.02,95％ CI 1.21-7.52,P＜0.05),Q4 vs Q3 in Uyghurs(OR =2.4,95％ CI 1.04-5.70,P＜0.05) were calculated.Both in Hans and Uyghurs,total testosterone/estradiol ratio in Q4 group was greater than that in other 3 groups (P＜0.05),while aromatase was lowered as compared with other 3 groups(P＜0.05).Conclusion Different levels of serum sex hormone may play an important role in the development of CHD in Uyghur and Han postmenopausal women.And the relationship between ethnic differences may exist.The aromatase activity may reduce the relationship between testosterone and estradiol. Key words: Sex hormone ; Coronary heart disease; Postmenopausal women ; Han ; Uyghur