PID 02027030 (Oystershell NV, Belgium), a skin cream for minor abrasions for dog and cats, was tested in a rat incision and rabbit excision model to determine wound-healing activity. The product contains plant extracts (Arnica Montana L., Calendula officinalis L., Echinacea purpurea (L.) Moench, Hamamelis virginiana L.) and essential oils (Lavandula officinalis Chaix, Melaleuca quinquenervia (Cav.) S.T. Blake, Salvia lavendulifolia Vahl and Thuja occidentalis L.) (8.25% v/w) in a non-natural excipient. The extracts and oils conform with the EU or French pharmacopeia (when available) and/or are standardized using marker compounds. In the incision model, 10 Sprague-Dawley rats were used to determine the effect of the product on wound breaking strength. Each rat served as its own control and had a total of 6 incisions. Peak breaking strength was measured using a tensometer and 50 N load cells. Six New Zealand White rabbits were used in the excision model to determine histologic changes. Each rabbit served as its own control and had a total of four 6-mm full-thickness dermal punches on the inner surface of the ear down to bare cartilage. Any wound with evidence of infection, desiccation, or necrosis was excluded from the study. Using Masson's trichrome stain, histologic measurement of hypertrophic scar was determined by light microscopy using two blinded observers. In both models, the treated wounds had the test product applied at a rate sufficient to cover the area, while the control wounds were left untreated. Skin was harvested 7 days post-application of product. All wounds were created and harvested in a matched fashion, and the data collected in a manner to allow paired analysis. Statistical analysis using a paired two-tailed Student's t-test was performed (significance set at p<0.05). Histological data also were analyzed using Chi-square. In the rat model, the product significantly increased tensile strength. In the rabbit model, the product significantly increased granulation, but decreased epithelialisation.