Background: Palmar warts are benign skin and mucous membrane lesions, caused by human papilloma virus (HPV) infection. In this case a 32 years old woman visited our outpatient department for the complaint of outgrowths over the front and back of both hands which was clinically diagnosed to be palmar warts along with headache. Methods: After detailed case taking and repertorization, at first individualized homoeopathic medicine, Natrum-muriaticum 200c was given and thereafter other drugs as per the indication were given. Within about one and half year of homoeopathic treatment, the patient started improving and continues to be free from her complains at the time of last followup visit in OPD and leaving a clear smooth skin demonstrating a positive role of individualised homoeopathic treatment in a case of verruca vulgaris. Results: Modified Naranjo Criteria for Homoeopathy tool was used to assess the causal relationship between homoeopathic intervention and clinical outcome. The MONARCH score(+9) suggested that the clinical improvement was likely attributable to the homoeopathic treatment, which is also evident from photographic images. Conclusions: This case study shows the utility of individual homoeopathic treatment in case of palmar wart. More studies and evidenced based clinical verification is required to establish the efficacy of homoeopathy in such cases.