Half-lives Of Isotopes Research Articles

Determinants of successful ictal SPECT injection in phase 1 epilepsy presurgical evaluation: Findings from the pediatric epilepsy research consortium surgery database project.

The main goal of presurgical evaluation in drug-resistant focal epilepsy is to identify a seizure onset zone (SOZ). Of the noninvasive, yet resource-intensive tests available, ictal single-photon emission computed tomography (SPECT) aids SOZ localization by measuring focal increases in blood flow within the SOZ via intravenous peri-ictal radionuclide administration. Recent studies indicate that geographic and center-specific factors impact utilization of these diagnostic procedures. Our study analyzed successful ictal SPECT acquisition (defined as peri-ictal injection during inpatient admission) using surgery-related data from the Pediatric Epilepsy Research Consortium (PERC) surgery database. We hypothesized that a high seizure burden, longer duration of video EEG monitoring (VEEG), and more center-specific hours of SPECT availability would increase the likelihood of successful ictal SPECT. We identified study participants (≤18 years of age) who underwent SPECT as part of their phase 1 VEEG from January 2018 to June 2022. We assessed association between ictal SPECT outcomes (success vs. failure) and variables including patient demographics, epilepsy history, and center-specific SPECT practices. Phase 1 VEEG monitoring with ictal SPECT injection was planned in 297 participants and successful in 255 participants (85.86%). On multivariable analysis, the likelihood of a successful SPECT injection was higher in patients of non-Hispanic ethnicity (p = 0.040), shorter duration VEEG (p = 0.004), and higher hours of available SPECT services (p < 0.001). Higher seizure frequency (p = 0.033) was significant only in bivariate analysis. Patients treated at centers with more operational hours were more likely to experience pre-admission protocols prior to VEEG (p = 0.002). There is inter-center variability in protocols and SPECT acquisition capabilities. Shorter duration of EEG monitoring, non-Hispanic ethnicity (when on private insurance), extended operational hours of nuclear medicine as noted on multivariate analysis and higher seizure frequency in bivariate analysis are strongly associated with successful ictal SPECT injection. In pediatric patients with drug-resistant epilepsy, single-photon emission computed tomography (SPECT) scans can be helpful in localizing seizure onset zone. However, due to many logistical challenges described below, which include not only the half-life of the technetium isotope used to inject intravenously during a seizure (called the ictal SPECT scan) but also available nuclear scanner time in addition to the unpredictability of seizures, obtaining an ictal SPECT during a planned elective inpatient hospital stay is not guaranteed. Thus, as healthcare costs increase, planning a prolonged hospital stay during which an ictal SPECT scan is not feasible is not optimal. We leveraged our prospective surgery database to look at center-specific factors and patient-specific factors associated with an ictal SPECT injection in the first, pediatric-focussed, large-scale, multicenter, prospective, SPECT feasibility study. We found that longer availability of the scanner is the most important center-specific factor in assuring ictal SPECT injection. Although seizure frequency is an important patient-specific factor on bivariate analysis, this factor lost statistical significance when other factors like patient insurance status and video EEG duration were also considered in our multivariable logistical model.

Effects of deformation on the cluster and the [formula omitted]-decay half-lives for isotopes of the Trans-lead and the undetected superheavy nuclei

In the present investigation, based on the Wentzel–Kramers–Brillouin (WKB) approximation, and by considering deformation of the cluster and the daughter nuclei, the cluster radioactivity half-lives of 22 Trans-lead isotopes ranging from 221Fr to 242Cm are calculated. Also, the α-decay half-lives of even–even isotopes for the superheavy nuclei with Z in the range 104≤Z≤118 are computed. For the cluster radioactivity, a preformation factor, Pc depending on the atomic numbers of the cluster and the daughter nuclei is used according to the Santhosh and Jose (2021). The α preformation factor, Pα is evaluated based on the cluster-formation model (CFM). A universal decay law (UDL) proposed by Qi et al. (2009), was used to obtain the decay half-lives of the cluster and the α-decay for checking the credibility of our approach. The effects of the deformation of decay products on the half-lives of the cluster and the α-decay have also been investigated by comparing the obtained half-lives considering deformation with ones of the spherical nuclei and the results of the UDL as well as the available experimental data. Comparison indicates that our calculated cluster and α-decay half-lives considering deformation reproduce the experimental data more accurately than the UDL and the spherical nuclei. Furthermore, the cluster radioactivity half-lives of some isotopes that whose cluster radioactivity is energetically allowed but not observed preciously yet, are predicted. Also, the cluster and the α-decay half-lives and the branching ratios between them for some not yet discovered superheavy isotopes with Z=122 and Z=124 are obtained.

Evaluated Material Attractiveness of Plutonium Composition from Economic Simplified Boiling Water Reactor (ESBWR)

The potential for misuse of nuclear fuel has prompted many to make efforts to prevent a country from acquiring nuclear explosive devices (weapons). Weapon utility equated with nuclear material attractiveness when applied to protection and security. Material attractiveness evaluated using an equation first developed by Masaki Saito, namely ATTR. ESBWR is one of the reactors of the BWR reactor type that is still operating. The purpose of this study is to evaluate Material Attractiveness based on the composition of plutonium in the ESBWR reactor, during reactor operation and after reactor operation. The ATTR concept utilizes the plutonium isotope composition to evaluate the material attractiveness aspect. Parameters such as BCM, Rossi-alpha, and neutron prompt life become additional aspects in evaluating material attractiveness. In the research results, the ATTR value decreased from the beginning of reactor operation until the reactor stopped operating. At the beginning of the reactor operation, it was categorizing as a weapon-grade with an ATTR value of 0.19 and when the reactor stopped operating it was categorizing as an unusable grade with an ATTR value of 0.012. At the time of cooling time up to 1x106 (one million) cooling time, the ATTR value increases by 0.019 which was categorizing as an unusable grade. After a cooling time of 1x106 (one million) years up to 1x107 (ten million) years, the ATTR value was 0.001 which categorized as an exempt level. This states that the increasing burnup value will further reduce the ATTR value. Likewise with the Rossi-Alpha and Bare Critical Mass values. Conversely, it will decrease the value of neutron lifetime. The ATTR value after the reactor operates up to one hundred years of cooling time increases and then decreases significantly after 1x106 (one million) years due to the half-life of plutonium isotopes. Likewise, the Rossi-Alpha and Bare critical mass values. However, it is different with the neutron fast lifetime.

Prediction on the alpha decay half-lives of 223−243Am isotopes

Prediction on the alpha decay half-lives of 223−243Am isotopes

Development of alternative methodology for normalization of the small animals PET scanner of LIM/CDTN

Normalization is a step taken to correct variations in count rates between detection channels of small animals PET scanners. In general, in laboratory practice, normalization is performed using a commercial source of germanium 68. Given the half-life of the Ge-68 isotope, the normalization source must be replaced every two years at most, which generates a significant spent for the Laboratory. The objective of this work was to develop and test an alternative rechargeable source to be used on normalization routine. The results indicated that the rechargeable source (18F-FDG) can be used to replace the commercial source.

Radioiodine internal dose coefficients specific for Koreans

This study developed internal dose coefficients for radioiodine, tailored to the Korean population, by incorporating the Korean biokinetic model along with the Korean S values. The observed differences in dose coefficients for Koreans compared to the International Commission on Radiological Protection (ICRP) reference values noticeably varied depending on physical half-lives of iodine isotopes. For longer-lived isotopes such as I-125 and I-129, significant differences in thyroid dose coefficients were observed, with ratios (Korean/ICRP) from 0.30 to 0.55, indicating that actual doses for Koreans can be considerably lower than those evaluated based on the ICRP data. However, for short-lived iodine isotopes, such as I-131, the thyroid dose coefficients were comparable to the ICRP reference values (ratio = 0.95–0.98). These comparable dose coefficients resulted from the lower thyroidal iodine uptake in the Korean model being almost entirely offset by the higher thyroid self-absorption S values in the Korean phantoms. Additionally, this study delves into the substantial differences in absorbed dose coefficients for non-thyroidal regions and effective dose coefficients, which arose not only from physiological/anatomical variability but also technical differences in phantom design. The use of Korean-specific dose coefficients is advisable particularly in scenarios predicting elevated doses, yielding a more precise and clinically relevant dose assessment.

Spontaneous fission half-life in Fm isotopes with nuclear energy density functional

A microscopic description of fission dynamics is important to understand the decay properties of neutron-rich heavy nuclei that are relevant to r-process nucleosynthesis. To provide a reliable and efficient method to evaluate the spontaneous fission half-life, we develop a method, called the constrained Hartree– Fock–Bogoliubov (CHFB) plus local quasiparticle random-phase approximation (LQRPA), to include dynamical residual effects in the collective inertia. With the CHFB + LQRPA, we evaluate the collective potential and the collective inertia along a mass-symmetric fission path in Fm isotopes with the neutron numbers N = 158–164. The obtained LQRPA inertia is much larger than the cranking one that ignores dynamical residual effects and shows a remarkable variation along the fission path. We estimate the fission half-life of the Fm isotopes using the action integral with the obtained collective potential and inertia. A large difference between the fission half-lives obtained with the LQRPA inertia and with the cranking inertia is observed. This indicates the importance of evaluating the collective inertia for estimating the fission half-life.

A systematic study of α-decay half-lives for Ac, Th, Pa, U and Np isotopes with A = 205–245 using the modified generalized liquid drop model

The Modified Generalized Liquid Drop Model (MGLDM) has been used for calculating the ground-to-ground states of [Formula: see text]-decay half-lives for various Ac, Th, Pa, U and Np isotopes in the mass number range of [Formula: see text]. To account for the nuclear proximity energy, the potential of Blocki et al. 74 [J. Blocki, J. Randrup, W. J. Swiatecki and C. F. Tsang, Ann. Phys. NY 105 (1977) 427] is used. The experimental [Formula: see text] values are used to evaluate the [Formula: see text]-decay half-lives. It can be observed that the logarithm of [Formula: see text]-decay half-life increases with increasing neutron number ([Formula: see text]), with evident minimum at the magic number 126, where the neutron shell is closed. The calculated results are compared with available experimental data and with the predictions of different empirical formulae such as, ARF, MARF, Royer, AKRE, Akrawy, NRB, VS, MVS, YQZR and MYQZR. It is found that the MGLDM is able to predict the experimental half-lives with a standard deviation of 0.6892 (the lowest one among all the other applied empirical formulae), and is therefore suitable for predicting the [Formula: see text]-decay half-lives for unknown and new heavy nuclei.

Trophic Position of the Species and Site Trophic State Affect Diet Niche and Individual Specialization: From Apex Predator to Herbivore.

Intra-species variability in isotopic niches, specifically isotopic total niche width (ITNW), isotopic individual niche width (IINW), and isotopic individual specialization (IIS), was studied using an innovative approach without sacrificing the vertebrates. Stable isotopes (δ13C, δ15N) in four body tissues differing in isotopic half-life were analyzed from four freshwater fish species representing different trophic positions. ITNW was widest for the apex predator (European catfish) and narrowest for the obligate predator (Northern pike). IINW exhibited a polynomial trend for the European catfish, Northern pike, and Eurasian perch (mesopredator), decreasing with body mass and increasing again after exceeding a certain species-dependent body mass threshold. Thus, for ectotherms, apex predator status is linked rather to its size than to the species. In herbivores (rudd), IINW increased with body mass. The IIS of predators negatively correlated with site trophic state. Therefore, eutrophication can significantly change the foraging behavior of certain species. We assume that the observed trends will occur in other species at similar trophic positions in either aquatic or terrestrial systems. For confirmation, we recommend conducting a similar study on other species in different habitats.

Systematic study of α-decay half-lives for Pa isotopes using MGLDM model

The [Formula: see text]-decay half-lives for odd [Formula: see text] Pa isotopes were estimated by using the modified generalized liquid drop model (MGLDM) in the neutron number range [Formula: see text]. These half-lives are found to be an excellent match with available experimental data certified by the least root mean-square error when compared with the other recently proposed empirical formulas. The applicability of MGLDM is proved on the odd [Formula: see text]-odd [Formula: see text] (even [Formula: see text]) nuclei in a successful manner in describing their [Formula: see text]-decay half-lives which are employed to predict half-lives of few unknown Pa isotopes. Our results are expected to provide more extensive and precise information of half-lives for the upcoming experiments eyeing on the boundaries of the trans-led nuclei.

Validation of a clinically applicable device for fast and accurate quantification of blood volume.

Determination of blood volume (BV) using the dual-isotope (e.g., 99m Tc-labeled red blood cells [99m Tc-RBC] and 125 I-labeled human serum albumin [125 I-HSA]) injection method is limited in medicine due to the long isotope half-life. However, BV has been determined in laboratory settings for 100 years using the carbon monoxide (CO)-rebreathing-based procedure, which allows frequent BV measurements. We investigated the reliability and accuracy of a semi-automated CO-rebreathing device by comparing it against the dual-isotope methodology and its ability to detect a known blood removal. In study A, BV was determined three times in ~2 h; twice using the device with rebreathing protocols lasting 2 (CO2min ) and 10 min (CO10min ) and once with the dual-isotope technique. In study B, the accuracy of the device was assessed by its ability to detect a 2% removal of BV. A good correlation was observed between both the CO-rebreathing protocols (r2 = 0.89-0.98; p < 0.001) and the dual-isotope approach (r2 = 0.89-0.95; p < 0.001). In absolute terms BV was 425 ± 263 mL and 491 ± 388 mL lower (p < 0.001) when quantified with the dual-isotope compared to the CO-rebreathing protocols. When reducing BV by 132 ± 25 mL (2%), the device quantified a lower (p < 0.001) BV of 150 ± 45 mL. This study emphasizes that the semi-automated device accurately determines small changes (i.e., 2%) in BV and that a high correlation with the dual-isotope methodology exists. The findings are clinically relevant owing to the method's simple and fast nature (the absence of radioactive tracers and reduced time requirements, i.e., ~15 min vs. ~180 min) and the possibility for repeated measurements within a single day.

Refining the delivery and therapeutic efficacy of cetuximab using focused ultrasound in a mouse model of glioblastoma: An 89Zr-cetuximab immunoPET study

IntroductionGlioblastoma (GBM) is the most common and deadly form of primary brain tumor. Between 30 % and 60 % of GBM are characterized by overexpression of the Epidermal Growth Factor Receptor (EGFR). The anti-EGFR antibody Cetuximab (CTX) showed a favorable effect for EGFR+ colorectal cancer but failed to demonstrate efficacy for GBM. Insufficient CTX passage through the blood–brain barrier (BBB) and the blood-tumor barrier (BTB) is assumed to be the primary determinant of the limited efficacy of this immunotherapy. ObjectiveUsing positron emission tomography (PET) imaging, we have previously demonstrated that focused ultrasound (FUS) combined with microbubbles (µB) allowed significant and persistent delivery of CTX across the BBB in healthy mice. In the current study, we investigated by PET imaging the combination impact of CTX and FUS on orthotopic GBM preclinical model. MethodsAfter radiolabeling CTX with the long half-life isotope 89Zr, PET images have been acquired overtime in mice bearing U251 (EGFR+) with or without FUS treatment. Autoradiography combined with immunofluorescence staining was used to corroborate CTX delivery with EGFR expression. A survival study was conducted simultaneously to evaluate the therapeutic benefit of repeated CTX monotherapy associated or not with FUS. ResultsEx vivo analysis confirmed that FUS enhanced and homogenized the delivery of CTX into all the FUS exposure area, including the tumor and the contralateral hemisphere at the early-time-point. Interestingly, FUS did not improve the long-term accumulation and retention of CTX in the tumor compared with the control group (no FUS). No significant difference in the CTX treatment efficacy, determined by the survival between FUS and non-FUS groups, has been either observed. This result is consistent with the absence of change in the CTX distribution through the GBM tumor after FUS. The neuroinflammation induced by FUS is not significant enough to explain the failure of the CTX delivery improvement. ConclusionAll together, these data suggest that the role of FUS combined with µB on the CTX distribution, even after multiple therapeutic sessions and glial cell activation is insufficient to improve survival of GBM mice compared with CTX treatment alone in this model.

Isotopic yields and spontaneous fission half-lives of 279Ds and 281Ds superheavy isotopes

In this paper, Isotopic yield and half-lives of cold spontaneous fission for [Formula: see text] and [Formula: see text] superheavy isotopes are studied. The interacting potential between fragments includes mean field proximity and Coulomb potentials. Fission [Formula: see text]-value, driving potential, [Formula: see text] and partial penetration probability of each possible individual fragmentation are calculated using [Formula: see text] approximation. According to the tunneling effect, the most favored pair of fragments is produced for the highest [Formula: see text]-value or the lowest driving potential. A few fragmentation with higher [Formula: see text]-value are selected for each atomic number Z. It is found that for [Formula: see text] isotope, the highest relative yield belongs to the [Formula: see text]Te + [Formula: see text]Ce fragmentation while for [Formula: see text], the combination [Formula: see text]Te + [Formula: see text]Ce has lowest driving potential and highest yield due to presence of fragments with magic or near magic proton and neutron numbers ([Formula: see text] and [Formula: see text]). By calculating yield of each fragmentation, its partial fission decay constant and then by summing over all decay constants for possible fragmentation, the fission decay constant for each superheavy isotope is obtained. Furthermore, half-life of each superheavy isotope is also estimated. Finally, the calculated half-lives using this method are compared with the experimental data. Good agreement achieved between our calculated half-lives and the experimental data.

Crossing N=28 Toward the Neutron Drip Line: First Measurement of Half-Lives at FRIB

New half-lives for exotic isotopes approaching the neutron drip-line in the vicinity of N∼28 for Z=12-15 were measured at the Facility for Rare Isotope Beams (FRIB) with the FRIB decay station initiator. The first experimental results are compared to the latest quasiparticle random phase approximation and shell-model calculations. Overall, the measured half-lives are consistent with the available theoretical descriptions and suggest a well-developed region of deformation below ^{48}Ca in the N=28 isotones. The erosion of the Z=14 subshell closure in Si is experimentally confirmed at N=28, and a reduction in the ^{38}Mg half-life is observed as compared with its isotopic neighbors, which does not seem to be predicted well based on the decay energy and deformation trends. This highlights the need for both additional data in this very exotic region, and for more advanced theoretical efforts.

Theoretical calculation of alpha decay half-lives of Neptunium nuclei using modified generalized liquid drop model

We considered the α-decay half-lives of neptunium (ZNp = 93) nuclei in the case of deformed nuclei in the range 219 ≤ A ≤ 239 using the generalized liquid-drop model (GLDM) with 1977 nuclear proximity potential suggested by Blocki et al. (1977) [29]. Also, we analyzed the α-decay half-lives of Np isotopes within the WKB method and the Deformed Proximity Potential Model (DPPM). We consider the quadrupole and hexadecapole deformations at θ=0, θ=30, θ=45, and θ=90 degrees. The calculated half-lives and the alpha decay branching ratios are compared with experimental data and are in good agreement. We compared the results obtained with the corresponding experimental data and with the models UNIV, UDL, SemFIS, the Coulomb and Proximity Potential Model (CPPM), SLB and Royer and it is found that they match well over a wide range. The calculated results are in reasonable agreement with the experimental data. Therefore, DPPM gives reliable and accurate results for favored α-decays in the neptunium mass region.

Half-life prediction of some neutron-rich exotic nuclei prior to peak A = 130

β-decay is amongst the key properties of nuclei required for the modeling of r-process nucleosynthesis. It also governs the flow of abundances among neighboring isotopic chains of high-mass elements. In the present work, a simple proton-neutron quasi particle random phase approximation (p–n-QRPA) model has been used for the calculation of β-decay half-lives of Rb, Sr, Y and Zr neutron-rich isotopes. For 97−103Rb, 98−107Sr, 101−109Y and 104−112Zr, where the experimental data were available, the half-life values are reproduced with reasonable accuracy. The same set of model parameters are later used to predict half-lives for few neutron-rich nuclei (104−112Rb, 108−113Sr, 110−114Y and 113−115Zr) where measured data is not available. The p–n-QRPA results (including only allowed transitions) are compared with previous calculations (allowed plus forbidden) and exhibit agreement within a factor of 2.0 when compared with the recent available experimental data.

αdecay of Po and Rn isotopes using different choices of impinging frequency

A comprehensive study of $\ensuremath{\alpha}$ particle emergence from $^{188\text{--}218}\mathrm{Po}$ isotopes is carried out within the framework of the preformed cluster model (PCM). The mass asymmetry coordinate and the interfragment separation play crucial roles in the identification of the most probable decay channel and the barrier penetration of decay fragments. First, the barrier characteristics are studied using two choices of radii [with surface diffuseness (${C}_{i}$) and without surface diffuseness (${R}_{i}$)]. The fragmentation behavior of $^{188}\mathrm{Po}$, $^{202}\mathrm{Po}$, and $^{218}\mathrm{Po}$ isotopes is explored for the identification of the most probable decay channel in view of the structure of the fragmentation potential. The $\ensuremath{\alpha}$ decay is found to be the most prominent decay mode in the chosen set of isotopes. The preformation and penetrative probability of the decay fragments is studied with respect to increase in the neutron number of the parent nucleus. The $\ensuremath{\alpha}$ decay half-lives of polonium isotopes are calculated using classical assault frequency (${\ensuremath{\nu}}_{c}$) and quantum mechanical assault frequency (${\ensuremath{\nu}}_{q}$) and a comparison is made with the experimental data. Here, the term assault frequency is basically the impinging frequency of an $\ensuremath{\alpha}$ particle near the surface of the parent nucleus. Further, the $\ensuremath{\alpha}$ decay half-lives of the $^{198\text{--}220}\mathrm{Rn}$ isotopes are calculated using the effective assault frequency (${\ensuremath{\nu}}_{e}$) parameter, and a comparison is made with the available experimental data.

Calculation of $$\alpha $$-decay half-lives for isotopes around $$N=Z$$ using different proximity-type potentials

Calculation of $$\alpha $$-decay half-lives for isotopes around $$N=Z$$ using different proximity-type potentials

Theoretical calculations of the alpha decay half-lives of 166−190Pt

Calculations of the α-decay half-lives of Pt isotopes have been carried out using the modified Gamow-like model (MGLM) and deformed Woods-Saxon potential model. In order to see the effect of using deformed nuclear potential on the α-decay half-lives of the Platinum isotopes, the spherical Woods-Saxon potential has also been employed in the computation. When compared with experimental data, all the modelsgive very good descriptions of the experimental half-lives. The comparison also suggests that the calculated half-lives considering deformation give better agreement with the experimental data than the results using spherical configuration. New parameter values were obtained for the MGLM model (termed MGLM2). The MGLM2 model gives better descriptions of the half-lives than the MGLM1 model.

Systematic study on α-decay half-lives of uranium isotopes with a screened electrostatic barrier* *Supported in part by the National Natural Science Foundation of China (12175100, 11975132), the Construct Program of the Key Discipline in Hunan Province, the Research Foundation of Education Bureau of Hunan Province, China (21B0402, 18A237), the Natural Science Foundation of Hunan Province, China (2018JJ2321), the Innovation Group

In the present work, we systematically study the α-decay half-lives of uranium (Z=92) isotopes based on the Gamow model with a screened electrostatic barrier. There are only two adjustable parameters in our model i.e. the parameter g and the screening parameter t in the Hulthen potential for considering the screened electrostatic effect of the Coulomb potential. The calculated results are in good agreement with experimental data, and the corresponding root-mean-square (rms) deviations of uranium isotopes with α transition orbital angular momentum l=0 and l=2 are 0.141 and 0.340, respectively. Moreover, we extend this model to predict α-decay half-lives of uranium isotopes whose α decay is energetically allowed or observed but not yet quantified in NUBASE2020. For comparison, the modified Hatsukawa formula (XLZ), the unified Royer formula (DZR), the universal decay law (UDL) and the Viola–Seaborg–Sobiczewski formula (VSS) are also used. The predictions are basically consistent with each other. Meanwhile, the results also indicate that N=126 shell closure is still robust at Z=92 and the spectroscopic factor is almost the same for uranium isotopes with the same l.