Theophylline Half-life Research Articles

Decreased theophylline half-life in cigarette smokers

In a group of 19 hospitalized patients, most of whom smoked, the half-life of theophylline following an I.V. aminophylline bolus was 3.6 ± 1.5 hours. When the young male control group was broken down by smoking history, 10 smokers had a theophylline half-life of 4.1 ± 1.2 hours, and 14 non-smokers a theophylline half-life of 7.2 ± 1.8 hours. The prolongation of half-life in the non-smokers was very significant (p<0.0001). These findings are consistent with observations that polycyclic hydrocarbons are strong inducers of microsomal enzymes involved in drug metabolism, and may help explain the individual variations of theophylline half-life.

Effect of theophylline of hepatic excretory function

ARTICLESEffect of theophylline of hepatic excretory functionJL Barnhart, and B CombesJL Barnhart, and B CombesPublished Online:01 Jul 1974https://doi.org/10.1152/ajplegacy.1974.227.1.194MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationCited ByRole of Extracorporeal Drug Removal in Acute Theophylline Poisoning27 November 2012 | Medical Toxicology, Vol. 2, No. 4Effect of theophylline on glucagon and secretin stimulated bile flowDigestive Diseases and Sciences, Vol. 29, No. 3Effect of diethyl maleate on the biliary excretion rate of infused sulfobromophthalein-glutathioneBiochemical Pharmacology, Vol. 31, No. 16Biliary excretion of sulfobromophthalein compounds in normal and mutant corriedale sheep. Evidence for a disproportionate transport defect for conjugated sulfobromophthaleinHepatology, Vol. 1, No. 5Effects of phenobarbital and 3-methylcholanthrene pretreatment on the plasma half-life and urinary excretion profile of theophylline and its metabolites in ratsBiochemical Pharmacology, Vol. 28, No. 19The role of cyclic AMP in canine secretin-stimulated bile flowJournal of Surgical Research, Vol. 27, No. 1Simultaneous determination of theophylline and its metabolites in urine21 August 2008 | Current Medical Research and Opinion, Vol. 6, No. sup6Theophylline therapy in asthmatic children: single-dose studies21 August 2008 | Current Medical Research and Opinion, Vol. 6, No. sup6A possible mechanism of choleretic action of 3-(2,4,5-triethoxybenzoyl)-propoionic acid (AA-149) in dogsEuropean Journal of Pharmacology, Vol. 48, No. 1Erythritol and mannitol clearances with taurocholate and secretin-induced cholereses.J L Barnhart, and B Combes1 February 1978 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 234, No. 2Dependence of the biliary excretion of iopanoic acid on bile saltsGastroenterology, Vol. 74, No. 2Urinary excretion of dye in dogs infused with BSP or its glutathione conjugateThe American Journal of Digestive Diseases, Vol. 23, No. 1The effect of bucolome on the canalicular bile formation and sulfobromophthalein transport maximum in the dogBiochemical Pharmacology, Vol. 25, No. 12Cyclic Amp in Secretin CholeresisGastroenterology, Vol. 70, No. 4Biliary Excretion of Metals22 September 2008 | Drug Metabolism Reviews, Vol. 5, No. 2Prostaglandin-induced choleresis in the ratExperientia, Vol. 31, No. 10Biliary Excretion of Xenobiotics14 February 2011 | CRC Critical Reviews in Toxicology, Vol. 4, No. 1Phenobarbital-enhanced biliary excretion of administered unconjugated and conjugated sulfobromophthalein (BSP) in the ratBiochemical Pharmacology, Vol. 24, No. 13-14Dosage of Theophylline in Bronchial AsthmaNew England Journal of Medicine, Vol. 292, No. 23Choleresis and hepatic transport mechanismsNaunyn-Schmiedeberg's Archives of Pharmacology, Vol. 290, No. 4 More from this issue > Volume 227Issue 1July 1974Pages 194-199 Copyright & PermissionsCopyright © 1974 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1974.227.1.194PubMed4843371History Published online 1 July 1974 Published in print 1 July 1974 Metrics

Central Mining--Rand Mines Group. Report for the year 1947

The use of theophylline in the management of apnoea in the newborn was studied in 33 preterm infants. Infants received a dose of 3 mg/kg, 13 of them every six hours, the remaining 20 every eight hours. All the infants had significantly fewer apnoeic episodes. In a pharmacokinetic study, the half life of theophylline was 30.3 +/- 7.2 hours and the clearance rate was 23.9 +/- 5.06 ml/kg per hour (means and SD). The plasma theophylline level remained constant at between 13 and 15 mg/l from the 5th day of treatment but, at the same time, the plasma levels of caffeine rose to a mean level of 4.4 mg/l. Caffeine was detectable in plasma at birth, and in preterm infants not receiving theophylline; plasma levels of caffeine tended to be similar to the levels in their mothers9 milk. These observations have led to clear conclusions on the optimum timing and dosage of theophylline, and on the need to monitor plasma levels of both theophylline and caffeine in newborn infants treated with theophylline.