Abnormal Hair Research Articles

An integrated approach to address the biodegradability of cosmetic formulations as part of a corporate sustainability strategy

AbstractObjectiveThe biodegradability of organic chemicals with usual down‐the‐drain disposal in their end‐of‐life is a key parameter to be considered by industries pursuing sustainability in their new product developments. It is a property that, once improved in any formulated product portfolio, will allow for a significant reduction in the presence of its ingredients in the natural environment, with a potential reduction in the pollution‐related environmental impact after consumption. This article aimed to propose an intelligent strategy for addressing biodegradability in the cosmetics sector, with the potential to support both product claims and corporate sustainability initiatives.MethodsThe framework for achieving a portfolio biodegradability indicator is composed of three levels of assessment, the first being an ingredient level assessment, the second being an individual product biodegradability calculation (PBI—Product Biodegradability Index), and finally a third level to calculate an emission‐based, company‐wide biodegradability indicator (GBI—Global Biodegradability Index). A case study is presented and discussed in detail, as a proof of applicability of the whole framework to support new developments for an improved environmental performance. Important insights in terms of ingredients assessment criteria are also presented.ResultsA fictitious portfolio composed of two soaps (a bar and a liquid), two hair care products (shampoo and hair conditioner) and one bath oil resulted in a GBI of 92.8%. The bar soap was the main contributor for this global index, with a PBI of 98.8% and a relatively high consumption volume of 1 ton/year, which accounts for approximately 66% of the total portfolio consumption. Other products, like hair care, presented lower PBIs, but their lower mass consumption representativeness within the portfolio prevented a significant negative impact on the global index. The main strategic directions derived from the case study, to ensure a stable and high biodegradability of the consumed organic mass, were properly discussed.ConclusionThe output of this framework provided an intelligent management strategy for innovation, where reformulation efforts can be targeted at products and ingredients with the highest potential to improve the biodegradability profile of the total organic mass released to the environment from a given portfolio.

Mexican Mint (Coleus amboinicus) Emulgel: Natural Solution for Antidandruff Hair Care

Today, the world is developing more and more in all sectors at a faster pace. But with all these developments, people are more prone to falling ill due to factors such as pollution, unhealthy lifestyles, busy work schedules, etc. Nowadays, even children suffer from the issue of dandruff and scalp infections which in later teenage years leads to unhealthy scalp and hair fall problems. Dandruff is a common scalp condition that affects individuals of all ages. It not only causes discomfort but also undermines hair health and aesthetics. Although scalp disorders are not among those that cause severe physical illness or morbidity yet are of great social concern. Scalp and hair conditions have more of a psychological impact on societies. Even minor changes in hair like graying of hair, affects the self-confidence and self-esteem of an individual. There are many types of medications and formulations to treat hair dandruff issues, one of which includes a novel drug delivery system such as “Emulgel” in the form of a mask. The anti-dandruff hair mask offers multiple benefits, including reduction in scalp inflammation and effective management of hair dandruff problems. Furthermore, it rejuvenates the scalp and nourishes hair follicles due to its natural vitamins and nutrient content. Keywords: Dandruff, Pityriasis capitis, Seborrheic dermatitis, Mexican mint, Herbal hair mask, Hair mask

Identification and characterization of alopecia areata subgroups regarding quality of life impairment based on demographic, clinical, psychological, and social factors

ABSTRACT The benign dermatological hair condition Alopecia Areata (AA) is known to impair Quality of Life (QoL), especially mental and social health, due to the accompanying visible appearance changes. Previous studies have identified demographic, clinical, social, and psychological variables related to QoL. Yet, the novelty of this study lies in examining how QoL differences in AA relate to (combinations of) these variables. The aim of the current study is to identify and characterize subgroups of AA persons with less or more QoL impairment by means of (combinations of) demographic, clinical, psychological, and social factors, including both potential risk (perceived stigmatization, avoidant coping, physical identity definition) and protective factors (disclosure, social support, emotion-focused coping and non-physical identity definition). An online questionnaire was filled out by 322 persons with AA, including the Dermatology Life Quality Index (DLQI) as QoL measure, Perceived Stigmatization Questionnaire (FSQ), brief COPE, Social Support Survey, a newly developed identity-definition measure, clinical characteristics, and demographics. Classification and Regression Tree (CART) analysis identified subgroups based on QoL outcome. Lowest QoL impairment was found in persons with low feelings of being flawed combined with low secretiveness. Low QoL impairment was also found in persons feeling flawed combined with low avoidant coping, low sensitivity to others’ opinions and older age. QoL impairment was intermediate in persons perceiving more social support in those with a younger age, and defining identity less on physical appearance in those sensitive to others’ opinions. Highest QoL impairment was characterized by feeling flawed combined with an avoidant coping style. Current findings provide indications for the identification of risk and protective profiles for QoL impairment and which factors to address in interventions to improve QoL in AA.

Актуальні проблеми цифрової обробки трихологічних зображень

This article explores modern methods of digital processing of trichological images for hair condition diagnosis. Special attention is paid to modules that employ computer vision techniques and machine learning algorithms to enhance diagnostic accuracy. Proposed automated image analysis solutions effectively detect hair structure anomalies and simplify the diagnostic process. The article discusses the advantages and limitations of existing approaches and prospects for their further development to improve medical procedures. Applications of these technologies in clinical practice are also examined.

Formation and Preparation of Herbal Hair Tonic

Today, people are keenly interested in hair preparations and conditioner materials that includes shampoos, hair tonic, and conditioner formulation with herbal extracts. Hair tonic is the product which is used in styling hair. The objective of the present study involved the preparation of herbal hair tonic through the use of jojoba, tulsi, and coconut oil and its evaluation for antifungal and antibacterial activity. The final preparation of these ingredients is formulated in batches with change in concentration. Each formulation is tested for antibacterial and antifungal activity. The formulation of different concentrations was characterized for proximate analysis including moisture content, total ash, acid insoluble ash, water soluble ash, water insoluble ash, sulphated ash. It means for antifungal and antibacterial activity the formulation gives good results, the formulation having good consistency, good spread ability, homogeneity, appearance, and pH.

Placental Extracts, Proteins, and Hydrolyzed Proteins as Active Ingredients in Cosmetic Preparations for Hair Loss: A Systematic Review of Available Clinical Evidence

Placentae and their derivatives have been used in both traditional and modern medicine, as well as in cosmetic sciences. Although hair loss is frequently mentioned among problems for which the placenta is supposed to be a remedy, the evidence seems rather scarce. The aim of this study was to highlight the clinical evidence for the efficacy of placenta products against baldness and hair loss. Methods: This systematic review was performed according to PRISMA and PICO guidelines. Database searches were conducted in PubMed, Google Scholar and Scopus. Results: Among the 2922 articles retrieved by the query, only 3 previously published clinical trials on placental products were identified. One study was a randomized controlled trial, in which the efficacy of a bovine placenta hair tonic was found to be comparable to that of minoxidil 2% in women with androgenic alopecia. Another controlled study showed that a porcine placenta extract significantly accelerated the regrowth of shaved hair in healthy people. The third study was an uncontrolled trial of a hair shampoo and tonic containing equine placental growth factor in women with postpartum telogen effluvium with unclear and difficult-to-interpret results. Due to the design and methodology of these studies, the level of evidence as assessed with the GRADE method was low for the first study and very low for the other two. Conclusions: The very limited scientific evidence available to date appears, overall, to indicate the efficacy of placental products in both inhibiting hair loss and stimulating hair growth. Unfortunately, the number of clinical studies published to date is very limited. Further, carefully designed, randomized controlled trials of well-defined placental products are needed to definitively address the question of the value of the placenta and its derivatives in hair loss.

Harnessing Herbal Ingredients in Hair Cosmetics: A Natural Approach to Hair Care

Hair plays a crucial role in the human body and it is imperative to uphold a healthy scalp. Various factors, including hormonal influences, age, gender, pollution, and food habits impact the hair. Herbal ingredients such as amla, hibiscus, brahmi, neem, saw palmetto etc are widely used to treat hair disorders such as premature hair loss, dandruff, and canities. Herbal ingredients may be used in hair shampoos, oils, tonics, serums, gels, conditioners etc. This article offers a detailed examination of the utilisation of natural components in hair care products, emphasising their importance and advantages in supporting scalp health, encouraging hair growth, and improving overall hair condition. It also reviews the sensory aspect and potential aromatherapy of herbal hair treatments. The article addresses the challenges and considerations related to herbal formulations, such as individual sensitivities, shelf life, and the need for transparency in labelling.

073. Tamoxifen - Associated Hirsutism: An Usual Side Effect in A 52-Year-Old Women with Malignant Neoplasm of Left Breast

Background: Hirsutism is a condition characterized by growth of excessive male-pattern (i.e., face, chest, abdomen, lower back, upper arms, and thighs) hair in women. The prevalence of hirsutism has been reported to be between 5% and 15% in women and can be caused by various factors, including the use of medications such as Tamoxifen. The modified Ferriman-Gallwey (mFG) score is the preferred and most widely used method for scoring excess terminal hair in the assessment of hirsutism. This case report aims to explore the relationship between Tamoxifen use and the development of hirsutism, as well as to discuss the potential mechanisms involved. Case: A 52-year-old female patient was diagnosed with a left breast tumor and underwent neoadjuvant chemotherapy followed by treatment with Tamoxifen 10 mg daily for six months. After treatment, the patient reported abnormal hair growth on her face, chest, arms, and legs. Conclusion: The use of Tamoxifen may contribute to the development of hirsutism in some patients. It is important to monitor these side effects and consider appropriate management strategies for patients experiencing hirsutism related to treatment.

In Vivo Imaging Techniques for the Human Scalp: A Systematic Review of the Literature.

Scalp inflammation and alopecia are distressing conditions for which patients regularly present to dermatology. Although some diagnoses can be made clinically, others require biopsy, which carries the risk of pain, infection, bleeding, and scarring. This review examines the existing literature regarding noninvasive in vivo imaging techniques and their evidence and utility in evaluating scalp pathology, with a focus on the diagnostics of hair conditions. A systematic literature search was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines without timeframe restrictions. The PubMed and Clarivate (Web of Science) databases were searched using the terms ("imaging" OR "in-vivo imaging" OR "non-invasive imaging" OR "non-invasive in vivo imaging" "imaging," "in-vivo imaging) AND ("human scalp disorders" OR "scalp" OR "hair loss" OR "alopecia"). Peer-reviewed randomized control trials (RCTs), prospective studies, retrospective studies, and case series or reports discussing in vivo imaging of the scalp published before 2022 were selected. Forty-two studies were included and discussed; modalities included laser devices (n = 27), ultrasound (US) (n = 13), infrared thermography (n = 1), skin capacitance imaging (SCI), and ultraviolet light-enhanced visualization (ULEV) (n = 1). The most common laser devices used were reflectance confocal microscopy (RCM), multiphoton microscopy (MPM), and optical coherence tomography (OCT). US techniques included high-frequency US (HFUS) and US biomicroscopy (UBM). Quality imaging of the scalp in the setting of alopecic, neoplastic, and inflammatory diseases is highly sought after. Many of these noninvasive imaging techniques show promise, each with individual advantages and disadvantages in imaging-specific conditions. Ultimately, noninvasive imaging techniques may be used to optimize patient management and minimize morbidity associated with scalp biopsies.

A Study on the Change of Hair Conditions Before and After Using Aroma Shampoo Bar

In this study, changes in hair condition after using aroma shampoo bars were investigated. Aroma shampoo was produced in the form of a bar (100 g) by complying with cosmetic safety standards in accordance with the Ministry of Food and Drug Safety notice. The essential oils used in aroma shampoo bars were lavender, juniper berries, cypress, peppermint, cedarwood, ylang ylang and rosemary as reference to previous studies. The subjects of this study were adults in their 20s or older, and consisted of two groups: a control group, 23 people and the experimental group, and 23 people. Aroma-free shampoo bars were used as the control group, and an aroma-containing shampoo bar was used as the experimental group. Measurement was measured once a week for 4 weeks before and after use. The hair measurement site is the top of the head, occipital region, left and right sides of the forehead. Measurement was performed with Aram Hubis’ ASG (AI-Scalp Grader). As a result of the study, there was a significant increase in hair condition changes in the density and number of the left forehead and occipital regions in the experimental group using aroma shampoos. This study has academic and social significance in that cleaning products, not products that nourish hair, can positively change hair condition and that it proved the effect of essential oils with quantitative data.

Satisfactory Clinical Response to Erlotinib in a Patient Diagnosed with Olmsted Syndrome.

Olmsted syndrome is a rare congenital keratinization disorder characterized by mutilating palmoplantar keratoderma (PPK), often accompanied by flexion deformity, periorificial keratotic plaques, and hair abnormalities. The majority of Olmsted syndrome cases are attributed to mutations in the TRPV3 (Transient receptor potential vanillin 3) gene(1). Herein, we aim to present a sporadic case of Olmsted syndrome with a recurrent c1717G>T p.Gly573Cys variant in the TRPV3 gene, demonstrating clinical improvement with the epidermal growth factor inhibitor Erlotinib.

Exosomes for Treating Hair Loss: A Review of Clinical Studies.

The regenerative properties of exosomes make them especially appealing to treat skin and hair diseases. Preclinical studies suggest that exosomes may fuel hair growth by stimulating dermal papilla cells, activating hair follicle stem cells, and promoting angiogenesis. However, very limited data are available on the safety and efficacy of exosome use in human subjects. To review the published literature on exosome use in human subjects with a focus on safety and the challenges facing clinical implementation in the treatment of androgenetic and nonscarring alopecias. A review was conducted of PubMed, EMBASE, and Cochrane databases and included 48 studies. Twenty-five studies were clinical trials, 14 case reports, 4 case series, 1 retrospective review, and 4 conference abstracts. Nine clinical studies were found relevant to alopecia. One hundred twenty-five patients received an exosome treatment for hair loss. Side effects were rare. However, in the broader field of dermatology, at least 10 serious adverse events have been reported. Although exosomes have many promising therapeutic applications, there is demand for larger well-designed clinical trials with extended follow-up periods to prove efficacy and a need for consistent manufacturing standards and regulatory oversight to ensure product safety.

Real-world safety profile of zanubrutinib: a disproportionality analysis based on the FAERS database

ObjectiveZanubrutinib is a second-generation Bruton’s tyrosine kinase inhibitor that has been approved for the treatment of several B cell malignancies. The aim of this study was to evaluate adverse events...

Formulasi Hair Tonic Ekstrak Etanol Kulit Buah Pepaya (Carica Papaya L.) dan Uji Efektivitas Pertumbuhan Rambut pada Marmut Jantan (Cavia porcellus)

Hair for humans has an important role, in addition to protecting the skin from adverse environments, hair also plays an important role in a person's appearance. Losing a lot of hair due to hair loss can cause a lack of self-confidence, disappointment, and frustration, so it must be addressed immediately so as not to worsen the condition that can cause baldness. This study aims to determine whether there is a content of secondary metabolite compounds in fresh herbal medicine, herbal medicine powder and ethanol extract of papaya fruit skin; ethanol extract of papaya fruit skin (Carica papaya L.) can be formulated in the form of hair tonic preparations; whether the difference in concentration of ethanol extract of papaya fruit skin (Carica papaya L.) provides different activities in triggering hair growth in guinea pigs. This research method uses a quantitative approach and is experimental with independent variables, namely papaya fruit skin, herbal medicine, and ethanol extract of papaya fruit skin with concentrations of 10%, 20%, 30%. Research stages: phytochemical screening of fresh papaya fruit peel, powdered simplicia and ethanol extract, hair tonic formulation containing ethanol extract of papaya fruit peel 10%, 20% and 30%, hair tonic evaluation includes: organoleptic, viscosity, stability, pH, irritation, and preference test. And hair growth activity test on male guinea pigs. The results showed that the ethanol extract of papaya fruit peel contains alkaloids, flavonoids, saponins, steroids, and glycosides, can be formulated into hair tonic (EEKP) that meets physical quality requirements. Hair tonic EEKP 30% is the best because it has high hair growth activity, which is an average of 16.375 mm where this EEKP 30% hair tonic has almost the same hair growth activity as the positive control, which is an average of 16.782 mm.

6625 Adrenocortical Oncocytoma: Illuminating The Clinical And Biological Behavior Of An Extremely Rare Tumor Of The Adrenal Gland

Abstract Disclosure: H. Usmani: None. M. Arguello, MD: None. Background: Only 120 cases of adrenocortical oncocytoma have been reported in English literature (1). Standardized diagnostic criteria, or a typical clinical or biological course, have yet to be established. 58 yo woman with PMH HTN, COPD, CREST syndrome on chronic prednisone, previous 38-pk yr smoker, pulmonary nodule, current vaper, was incidentally found to have a left adrenal mass when she went for CT abd pelvis with IV and oral contrast to evaluate for suspected diverticulosis and anemia. CT showed a mass in the left adrenal gland measuring 5.6 x 4.4 cm in size, heterogeneous in density, with possible areas of necrosis. It is unclear how long the adrenal mass was there since the patient never had a CT scan before. Patient was asymptomatic except 50 lb wt loss in the last couple of years with a feeble appetite, self-reported abnormal hair growth (no hirsutism on exam), voice deepening attributed to smoking, and HTN- well controlled with nifedipine. Patient has no FHx of endocrinopathy. Adrenal function tests wnl except for plasma free normetanephrines slightly high at 1.64 nmol/L, which was unlikely from tumor considering tumor size. Normal adrenal function tests included 11-deoxycortisol, DHEA-S, plasma-free metanephrine, aldosterone, renin, aldosterone: renin ratio, androstenedione, ACTH, 1 mg overnight dexamethasone suppression test.She underwent left-sided lap adrenalectomy 4 mos after discovery of adrenal mass, with no complications. 6 days after surgery, a left in JP drain caught on a door at patient’s home, causing splenic subcapsular tear requiring emergent splenectomy. The path report shows an encapsulated neoplasm consisting of sheet-like proliferation of eosinophilia polygonal cells with nuclear atypia, low mitotic activity, and no capsular or vascular invasion. Immunohistochemical markers show neoplastic cells positive for SF1, Mart1, inhibin (focal), and synaptophysin (focal); negative for CK-OSCAR, CK7, CK20, chromogranin, HMB45, and TTF-1, Ki67 and pHH3 show low proliferative index. The pathology slides were sent to U of M, where the diagnosis of adrenal cortical oncocytoma was made. Removal of oncocytoma has not affected patient’s weight, blood pressure, deep voice, or hair growth on 4 month follow up. Lin-Wiess-bisceglia system (2) suggests a benign lesion. But, as mutation rate for this rare tumor is unclear, plan for CT abd pelvis in 1 yr. Conclusion: This case elucidates the clinical and biological course and pathologic diagnosis of an exceedingly rare adrenal tumor.

B-089 Pseudo-clonal Increased IgG4 with Polyclonal Distribution Demonstrated by MALDI-TOF-MS in a Pediatric Patient with Tricho-Hepato-Enteric Syndrome (THES)

Abstract Background THES is a rare autosomal recessive syndromic enteropathy caused by pathogenic variants in two genes, the Tetratricopeptide Repeat Domain 37 (TTC37) and Ski2 Like RNA Helicase (SKIV2L), that encode components of the human SKI complex involved in RNA degradation. This disease is characterized by several clinical features with variable penetrance including intractable congenital diarrhea, wooly hair abnormalities, intrauterine growth restriction, facial dysmorphism, immune dysfunction, liver abnormalities, and skin hyperpigmentation. Hypogammaglobulinemia with low IgG and normal to low IgM levels have been described in these cases which may require intravenous immunoglobulin (IVIG) replacement therapy. Some cases have a reduced population of switched memory B cells, T cells with reduced IFN-γ secretion, and hyporesponsive NK cells. Our patient is a 4-year-old female reported to have a homozygous TTC37 mutation with clinical manifestations of TPN dependence, liver fibrosis with portal hypertension, splenomegaly, developmental delay, thrombocytopenia and anemia requiring transfusion, and a history of hypogammaglobinemia requiring IVIG replacement. Patient would go on to develop elevated immunoglobin levels leading to additional testing described below. Methods Serum total protein analysis performed using the using Siemens Atellica CH Total Protein II test (Weichselbaum method using biuret reagent). Serum immunoglobin (IgA, IgG and IgG), IgG subclass, and kappa/lambda free light chain level analysis performed by turbidimetric photometry assay using a Binding Site Optilite analyzer. Serum protein electrophoresis and immunotyping performed using CAPILLARYS 2 capillary zone electrophoresis and immunosubtraction with antisera. Serum protein immunofixation performed using Sebia Hydrasys 2 with Hydragel 9 IF Maxi kit. Confirmation and final determination of serum immunoproteins performed at our reference laboratory using MASS-FIX (MALDI-TOF MS) matrix-assisted laser desorption/ionization-time of flight mass spectrometry after patient serum applied to 5 separate immunoaffinity resins specific to immunoglobulin G, A, M, K, and L for purification. Results Initial testing showed a broadly migrating beta-gamma region IgG kappa monotypic restriction measuring 1.7 g/dL, with predominantly kappa subtraction and trivial lambda subtraction by immunosubtraction; serum free kappa/lambda light chain ratio was increased at 22.94. Serum immunoglobins and free light chains measured (mg/dL): IgA 738 (15 - 160), IgM 48 (50 - 240), IgG 2,805 (405 - 1,160), free kappa 20.42 (0.33 - 1.94), and free lambda 0.89 (0.57 - 2.63). IgG subclasses measured (mg/dL): IgG1 533 (320 - 950), IgG2 174 (50 - 340), IgG3 16.9 (10.0 - 120.0), IgG4 1,221.1 (2.0 - 110.0). Additional serum protein values included (g/dL): total protein 8.10 (6.00 - 8.30), albumin 2.97 (3.43 - 4.84), alpha-1 0.32 (0.21 - 0.44), alpha-2 0.52 (0.54 - 0.97), beta globulin 3.42 (0.65 - 1.03), and gamma globulin 0.87 (0.70 - 2.30). The polyclonal nature of the IgG4 spike was later demonstrated by the MASS-FIX mass spectrograph. Conclusions MASS-FIX is a useful addition to the toolset used in the diagnosis of possible monoclonal gammopathies and protein disorders, especially where broad monotypic restrictions are observed or in patients with abnormal presentations for monoclonal gammopathies. Using current standard techniques, the above case could have been incorrectly classified as a monoclonal process resulting in unnecessary cost and incorrect treatment.

The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma.

The hair follicle can cycle throughout a lifetime, undergoing periods of growth (anagen), regression (catagen) and relative quiescence (telogen). The time that a hair follicle spends in each of these stages is crucial to determine the length of hair fibre that it produces. Perturbations in this regard can manifest in various hair diseases such as anagen effluvium, or acute and chronic telogen effluvium. The established 'dogma' when considering how many hair follicles there are in each stage has long been that the majority are in anagen (85%-90%), followed by telogen (10%-15%) and catagen (1%-2%). These values are based on various studies using different methodologies such as hair plucking, phototrichograms and histology. However, these methods have flaws when it comes to differentiating between catagen and telogen follicles. We sought to determine the catagen: telogen ratio through the exvivo stereomicroscopic examination of hundreds of hair follicles removed from the occipital scalp of 14 Caucasian males during routine hair transplantation procedures. Using this methodology, and in agreement with a similar observation by another research group, we found that the percentage of catagen hair follicles was higher (7.5%) than telogen (3.5%) in all patients assessed. Consequently, we believe that the percentage of catagen follicles is clearly underestimated and therefore challenge the current established dogma.

Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis.

Autosomal recessive congenital ichthyosis (ARCI) is a rare genodermatosis categorized among nonsyndromic ichthyoses. While ARCI patients often manifest hair abnormalities, their impact on the quality of life remains underreported in the literature. This study aims to comprehensively characterize the clinical and trichoscopic findings of alopecia in ARCI patients. A prospective study spanning from January 2019 to December 2021 (3 years) was conducted at the Dermatology Department of Habib Thameur Hospital, Tunis, Tunisia. Clinical and trichoscopic examinations were performed on the hair of the participants, with molecular studies conducted on 15 patients. The study included 30 patients, predominantly female (male/female = 0.58), with a mean age of 20 years. Twenty-eight patients were born from consanguineous marriages. Lamellar ichthyosis was observed in 22 cases, while congenital ichthyosiform erythroderma and bathing suit ichthyosis were each present in 4 cases. The ARCI severity score, assessed using the Visual Index For Ichthyosis Severity scale, had a mean value of 15 (4-28). Alopecia emerged as a prominent finding in 11 patients, presenting as hairline recession (13%), multiple patchy alopecia (27%), and alopecia of the eyebrows (13%). Trichoscopic findings included interfollicular and perifollicular scaling, perifollicular lamellar hyperkeratosis, peripilar casts, interfollicular erythema, loss of hair openings, predominance of single hair follicles, broken hair, vellus hair, anisotrichosis, pili torti, dystrophic hair, and comma hair. Several trichoscopic findings showed statistically significant associations with the severity of ARCI. In our study, we only included 30 patients due to the rarity of this genodermatosis. Contrary to previous perceptions, alopecia is a notable finding in ARCI, particularly in patients with a severe form. This study provides a detailed characterization of alopecia in ARCI, shedding light on its prevalence and associated trichoscopic features, thereby enhancing our understanding of this dermatological condition.

Hair fragility (trichorrhexis nodosa) in alopecic Pomeranian dogs.

While alopecia associated with hair cycle arrest (HCA, Alopecia X) is well-recognised in Pomeranian dogs, the authors are unaware of reports of concurrent hair fragility. Following the observation of frequent hair shaft abnormalities in alopecic Pomeranians, we hypothesised that hair fragility events would be more frequent in dogs with a phenotype of HCA when compared to dogs with normal coats. Eight alopecic Pomeranian dogs or crosses with a phenotype of HCA and 36 unaffected Pomeranians with owner-reported normal hair coats. All affected dogs underwent dermatological examination and clinicopathological evaluations. Hair samples, plucked from affected areas or obtained by brushing from unaffected dogs, were examined microscopically for structural abnormalities. Hair fragility events were characterised as trichorrhexis nodosa (TN) or longitudinal splits and were expressed per 10 mg of hair. A reference interval was calculated from the number of hair fragility events in the samples from unaffected dogs. The upper reference limit (with 90% confidence) from samples of 35 unaffected Pomeranians (one outlier excluded) was 9.75 hair fragility events per 10 mg of hair. The median (range) of fragility events in eight dogs with a phenotype of HCA was 66.0 (30.2-166.7) per 10 mg of hair. Clinicians should routinely perform trichography in Pomeranians with HCA because abundant hair abnormalities, particularly TN, may contribute to poor hair coat quality. Further studies are required to establish the pathophysiology of and treatments for these fragility events and to determine their predictive value for HCA.

Synthesis and Analyses of Hair Conditioner with Natural Essence from <i>Picea Pungens Glauca</i> Leaves

The main purpose of this study is to synthesize hair conditioners using natural essence sources and determine the fluid properties of hair conditioners. The essence obtained from Picea pungens glauca (Blue Spruce Pine) leaves using Soxhlet extraction via ethanol was used to formulate a hair conditioner. Picea pungens, native to North America, are resistant to wind and air pollution and are grown in many regions. It has a strong flavor due to the terpenes in the leaf extracts. Here, we formulated a hair conditioner with these extracts, and then the physical and chemical features of the conditioners were examined. Characterization studies were done by viscometer, gas chromatography, gas chromatography-mass spectrometry, Fourier transform infrared spectroscopy, and ultraviolet-visible spectroscopy. On the other hand, the shear rate and viscosity values were used to determine whether the synthesized creams were Newtonian or non-Newtonian. The conditioners were determined to be Newtonian fluids based on the results obtained.