Topical metronidazole (10%) and sucralfate (7%) cream has been previously demonstrated to decrease postoperative pain after hemorrhoidectomy. The aim of this study was to evaluate the effect of topical metronidazole(10%) and sucralfate (7%) cream in reducing postoperative and after defecation pain of hemorrhoidectomy. A total of 60 patients aged 25-65 Years were studied. Patient were divided into 2 group patient in group A received topical metronidazole (10%) and sucralfate (7%) in group B received placebo (petrolatum cream) pain was assessed using a visual analog scale preoperatively and postoperative hours 5 hrs, 10 hrs and days 1, 3, 7, 14 the use of narcotics, analgesics and complication were recorded. Patient in group A had significantly less postoperative pain than those in group-B upto 14 days (p<.04) in group-A after defecation pain was ranked significantly lower at day 3. Patient required lesser analgesics postoperatively on day 3 and 7 (P<.04) We concluded that topical (10%) metronidazole and (7%) sucralfate significantly reduce post hemorrhoidectomy pain and postoperative defecation pain compared with that of the placebo control group.