Aims: This study investigates the effect of consumption of an edible seafood - Egeria Radiata (Clam) on hematological parameters in rats. Study Design: Albino Wistar rats were assigned to 3 groups of 5 rats each. Place and Duration of Study: Department of Physiology, University of Calabar, Nigeria. Methodology: The protein content of the extract was estimated as 24.60±.1mg protein / mL. Graded doses of the extract (1.64 ‐ 104.96mg protein / kg) were administered (i.p) in rats to determine the LD 50 value of the extract. Based on the LD 50 value (56.36mg/kg), two test doses (low dose - 7.0 mg protein / mL and high dose - 52mg protein / mL) were selected and administered to two groups of rats orally and daily for six weeks, while a third group of rats served as the control, n = 5. Blood samples were obtained from all the rats via cardiac puncture for the analysis of the various hematological indices. Results: Both the low and high doses of the extract produced significant increases in RBC count ( P< .001), Hb ( P< .001) and PCV ( P< .001) compared with control. MCH (P< .001), MCHC ( P< .001), total WBC count ( P< .001) and platelet count ( P< .001) were also increased in the extract groups. The extract groups had significant reductions in mean platelet volume ( P< .001), platelet distribution width ( P< .001) and platelet large cell ratio ( P< .001) compared with control.