Abstract Introduction: Potentially malignant disorders are highly prevalent in India. Therefore, early identification and prevention of these lesions may reduce the incidence and increase the prognosis of oral cancer patients. In the present study, we tried to assess the correlation between the C-reactive protein (CRP) levels in patients who had been diagnosed with oral submucous fibrosis (OSMF) and compared it with normal individuals. We also tried to correlate CRP levels in different stages of diseases. Materials and Methods: This comparative study consisted of 60 patients/subjects coming to the outpatient department of oral medicine and radiology, who were selected according to the inclusion and exclusion criteria for the study. They were further divided into two equal groups. Group 1 comprised OSMF patients, and Group 2 comprised the control group. Detailed case history was taken along with habit history, and the habit index was calculated. Blood was collected from each patient for blood reports. After the histological examination, patients were categorised into different stages of the disease. The Spinreact CRP-turbinates kit (SPINREACT) was utilised to measure serum CRP quantitatively. Data collected were entered into an Excel sheet, and a Chi-square and ANOVA test were used for analysis. A significance threshold of P < 0.05 was set for all tests, meaning that a P value below this threshold indicates statistical significance. Results: OSMF was most common in males and younger to middle age groups. In patients with OSMF, serum CRP levels were elevated; however, this increase was not statistically significant when compared to the control group. There is no discernible change present in OSMF according to stages. Conclusion: The results of this study showed that the OSMF had higher levels of CRP than the healthy subjects, indicating that CRP is a biomarker that can be used to gauge the severity of a disease. It is yet unknown if elevated CRP levels represent a risk factor for the development of cancer or if they are raised before the biological genesis of cancer. Therefore, to evaluate pre- and post-treatment serum CRP levels and determine the disease’s status, more research with larger sample sizes is required.
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