Nicotine is one of the most lethal poisons known to man. Some conception of its extreme toxicity may be gained by comparing it with hydrocyanic acid, which is of approximately equal potency. Nicotine is present in appreciable quantities in tobacco (ranging from 0.6 to 8 per cent),<sup>1</sup>the poorer grades containing relatively more than the better grades. Since tobacco is used so widely both for smoking and for chewing (including snuff), it is amazing that so few instances of fatal poisoning from nicotine have been recorded. As far as smoking is concerned, a possible explanation may be the destruction of the drug by combustion and also its expulsion with the smoke. Then too, marked tolerance acquired by the habitual use of tobacco is undoubtedly an important factor. Consequently, in a majority of instances nicotine poisoning among adults has been traced to the ingestion of some strong solution of the
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