A Prospective Experimental, randomised clinical trial was conducted at RHMC, Rajkot for a period of 6 months with a 3 – month intervention and follow up period, aiming to ascertain the Effectiveness of OCIMUM SANCTUM through a clinical trial. In this study, after Screening of patients, it is observed that the most cases were presented with Respiratory symptoms, GI symptoms, GUT symptoms and Reproductive symptoms. 30 cases completed the study in which marked improvement were seen in 50% cases, moderate improvement in 30% cases and mild improvement or no improvement is observed in 20% cases. Ocimum Sanctum offered highly significant relief to the patients suffering from Respiratory complaints markedly, followed by the GIT symptoms, GUT symptoms and Reproductive symptoms with the use of 30 CH potency. Ocimum sanctum is safe with no adverse effects. In future, studies can be done for clinical verification of Ocimum Sanctum as it is a small and lesser-known drug and there is a limitation of time duration. Keywords: Ocimum Sanctum, Homoeopathy, Randomized clinical trial study.