Composition Of Gum Research Articles

Development of an Intranasal In Situ System for Ribavirin Delivery: In Vitro and In Vivo Evaluation.

Recently, ribavirin has demonstrated effectiveness in treating glioblastoma through intranasal administration utilizing the nose-to-brain delivery route. Enhancing ribavirin's bioavailability can be achieved by utilizing intranasal stimuli-responsive systems that create a gel on the nasal mucosa. The research examined thermosensitive, pH-sensitive, and ion-selective polymers in various combinations and concentrations, chosen in line with the current Quality by Design (QbD) approach in pharmaceutical development. Following a thorough assessment of key parameters, the optimal composition of gellan gum at 0.5%, Poloxamer 124 at 2%, and purified water with ribavirin concentration at 100 mg/mL was formulated and subjected to in vivo testing. Through experiments on male rats, the nose-to-brain penetration mechanism of the active pharmaceutical ingredient (API) was elucidated, showcasing drug accumulation in the olfactory bulbs and brain.

Highly efficient malachite green adsorption by bacterial cellulose and bacterial cellulose/locust bean gum composite

In this study, bacterial cellulose (BC) and BC/locust bean gum (LBG) composite produced from banana hydrolysate were both used as the adsorbent for various organic dyes adsorption especially for malachite green (MG) adsorption for the first time. The BC/LBG(2%) composite exhibited significantly enhanced swelling rate and textural characteristics while maintained the basic structure of BC as depicted by XRD, FT-IR, and NMR, providing a foundation for its application as an excellent adsorbent. The composite exhibited a high adsorption rate and adsorption capacity for MG (exceeding 95 % and 2000 mg/g), and had a good selectivity for MG adsorption in the solution containing crystal violet (CV), rhodamine B (RB), and methyl orange (MO). The MG adsorption process conformed to multiple models including Langmuir and pseudo-first-order models. And the adsorption mechanism mainly comprised chemical adsorption (hydrogen bonding and electrostatic interactions) and physical adsorption. The reusability of BC/LBG(2%) composite was attractive for industrial application that the MG adsorption rate reduced merely a little (still higher than 88 %) after the 5th regeneration process. Overall, considering its adsorption capacity, selectivity, and reusability, BC/LBG(2%) composite prepared by in-situ fermentation with LBG addition was a competent adsorbent for MG adsorption and MG containing wastewater treatment.

Kaolinite–Arabic gum composite as efficient adsorption material for chemically active compounds with potential insecticidal properties from Momordica charantia leave extract

Synthetic insecticides used worldwide are not environmentally friendly, so there is need for harmless insecticides from bio-sources. The present work is therefore aimed at studying the adsorption of M. charantia leaf extract (EL) on a clay/arabic gum composite. Two composite samples containing clay/arabic gum of 2.5 g/7.5 g noted CP1 and 2.5 g/15 g noted CP2 were each prepared and characterized by X-ray fluorescence (XRF), X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscope (SEM). Results show that the clay used is of the Kaolinite (kao) type. Arabic gum made it possible to increase the interlayer spaces of kao of the order of 2θ of 12.16° to 2θ of 7.25° and 6.60° for composite 1 (CP1) and composite 2 (CP2) respectively. Results best fitted Freundlich isotherm model for all the adsorbents with CP2 having better adsorption capacity of 9.05 (mg/g)(L/mg)1/n compared to 5.32 and 5.65 (mg/g)(L/mg)1/n for CP1 and kao respectively. The adsorption process was exothermic, non-spontaneous and occurred by physisorption mechanism. The pseudo-second-order kinetic model best fitted the experimental data for the samples with adsorption occurring faster on CP1 (0.20 g/mg/min) compared to kao (0.06 g/mg/min) and CP1 (0.04 g/mg/min). Results show that arabic gum composite with increasing mass of the arabic gum is more effective in binding M. charantia leaf extract. The arabic gum composite with adsorbed M. charantia leaf extract could be used as an insecticide powder for the preservation of foodstuffs

Experimental and Computational Study of Modified Biopolymer Xanthan Gum with Synthetic Vinyl Monomers for Enhanced Oil Recovery

AbstractUtilizing xanthan gum, a biodegradable polymer, in enhanced oil recovery (EOR) is imperative wherever there is a need for innovation in oil production that is both cost-effective and environmentally friendly. Xanthan, chosen for its natural sourcing, availability, controllability, eco-friendliness, and biodegradability, proves resilient against harsh reservoir conditions owing to its rigid structure and elongated polysaccharide chains. This study investigates two modified xanthan gum composites, achieved by grafting with synthetic vinyl monomers through emulsified polymerization. Spectroscopic characterization using FTIR and 1H-NMR, along with surface morphology analysis via atomic force microscopy (AFM) and thermal behavior screening through TGA analysis, elucidates the properties of these modified composites. Rheological behavior under reservoir conditions, including stress scanning and viscosity/shear rate dependency, was evaluated. Material modeling with the Materials Studio program simulated the equilibrium adsorption of xanthan and modified biopolymer chains on SiO2-quartz crystal to assess wettability alteration. Simulation results indicate that XG-g-AM, MMA&TEVS exhibit greater stability and surface coverage with more negative electrostatic energies compared to XG and XG-g-AM&MMA. The laboratory runs on a sandstone-packed model to identify the disclosed XG-g-AM&MMA and XG-g-AM, MMA&TEVS biopolymers as promising EOR candidates and wettability modifiers in challenging sandstone reservoirs, as per experimental outcomes.

Enhanced EMI shielding effectiveness of green Eucommia ulmoides gum composites through heterogeneous and crystalline structures

In order to mitigate the increasing severity of electromagnetic interference (EMI), it is imperative to develop advanced rubber composites. Despite recent advancements in structural design and filler hybridization for enhancing their EMI shielding performance, challenges persist in terms of suboptimal mechanical properties and intricate processing techniques. To overcome these limitations, bio-based Eucommia ulmoides gum (EUG) composites with segregated network structures were fabricated by simple mechanical blending, capitalizing on the characteristics of highly cross-linked rubbers with restricted molecular chains. Highly cross-linked EUG (HCE) effectively segregated the conductive fillers into the EUG phase, while the crystallization of EUG promoted the dispersion of fillers within the amorphous region of the EUG. Therefore, a highly efficient 3D conductive network was formed due to the segregated structure and crystallization, enabling the EUG/HCE/CNT composite to achieve an exceptional shielding effectiveness (SE) value of 83.0 dB with a high absorption loss ranging from 8.2 GHz to 12.4 GHz.

Correction to “Heat‐responsive shape memory Eucommia ulmoides gum composites reinforced by zinc dimethacrylate”

Correction to “Heat‐responsive shape memory <i>Eucommia ulmoides</i> gum composites reinforced by zinc dimethacrylate”

Formulation Consideration of Medicated Chewing Gum: A Review.

In recent times, technological and scientific advances have been made in studying and developing orally delivered medication. Such studies demonstrate the importance of the oral route among patients. The accuracy of drug delivery is very important to achieve a successful therapeutic effect in the case of various pharmaceutical products. A novel drug delivery system adds new benefits or advantages to a drug. This review covers all the aspects of medicated chewing gum (MCG) as a new drug delivery method, including the benefits and drawbacks, manufacturing methods, type of MCG, composition of chewing gum, evaluation parameters, factors that affected the release of API, its pharmaceutical significance, various marketed chewing gum and chewing gum packaging. Chewing gum as a drug delivery system has the potential to cure or prevent various indications, such as analgesic, CNS stimulation, smoking cessation, motion sickness, and treatment and prevention of dental caries or gingivitis. Pharmaceutical distribution to the oral mucosa can be made more convenient and enticing with the help of MCG. Compared to conventional techniques, this delivery system has a longer-lasting effect, which makes it a viable option for treating digestive problems, headaches, migraines, coughing, anxiety, and allergies.

Eco-friendly guar gum composites as solid-state electrolytes

Solid-state Guar gum electrolytes were prepared through the solution casting technique, employing a composition of 70 % Guar gum and 30 % ZnSO4·7H2O(GZ3). Different weight concentrations of nano ZrO2 (2.5 %, 5 %, 7.5 %, and 10 %) were introduced into the present Guar gum electrolytes. As prepared ZrO2 nanofiller substituted Guar gum electrolytes were examined by XRD, FTIR, DSC, and SEM to evaluate the amorphous characteristics, complexation, glass transition temperature, and surface morphology, respectively. Electrochemical impedance was utilized to examine the frequency-dependent ionic conductivity and dielectric properties of prepared ZrO2 nanofiller-substituted Guar gum electrolytes. At a temperature of 100 °C, the Guar gum electrolyte with10 % Nano ZrO2 exhibited an ionic conductivity of 3.19 × 10−3 S/cm, whereas, at room temperature (RT), it recorded a value of 1.09 × 10−3 S/cm. The activation energy for these electrolytes varied within the range of 0.26 eV–0.39 eV. Furthermore, an investigation of the frequency-dependent dielectric properties revealed a significant tail in the low-frequency region and the presence of space charge polarization within the electrolyte. The study also explored the relaxation time and hopping mechanism through dielectric modulus parameters. Moreover, a flexible Zn-based electrochemical cell was fabricated using a formulation comprising 70 % Guar gum, 30 % Zinc salt, and 10 % Nano ZrO2. The outcomes revealed an open circuit voltage of 0.82V, a discharge rate of 0.04C sustained over 25 h, with an average current discharge rate of approximately 1.4 mA per hour, resulting in an electrochemical-specific capacity of around 45mAh/g. Additionally, a solar cell device was fabricated using Guar gum electrolytes, and the photovoltaic parameters were computed. The maximum overall power conversion efficiency (ƞ) reached 4.79, with short-circuit photocurrent density (Jsc) at 9.66 mA/cm2, open-circuit voltage (Voc) at 725 mV, and fill factor (FF) at 0.65.

Properties of donuts enhanced by gum and apple pomace powder for development of low-fat fried food

The development of low-fat donuts with the addition of gum (guar gum and arabic gum) and apple pomace powder was carried out in this study. The purpose of this study was to improve the nutritional content of the donuts, especially in reducing the fat content of the donuts by using gum and adding apple pomace powder. The variables in this study were the composition of gum as an ingredient for donuts and the addition of apple pomace powder. Analysis of the dough and donuts characteristics, as well as the donuts appearance and nutritional content, was carried out. Analysis of the donuts texture profile, such as the hardness, and springiness, increased when the composition of apple pomace powder was increased. The proximate composition of donuts (% water, ash, fat, protein and carbohydrates) was analyzed, and there was reduction of fat in the donuts. This study established that adding gum (guar gum and arabic gum) and apple pomace powder can improve the properties of the donuts. Overall, there are significant differences in consumer acceptance, especially in texture and crumb color.

Banana fibre-chitosan-guar gum composite as an alternative wound healing material

Bio-composites, which can be obtained from the renewable natural resources, are fascinating material for use as sustainable biomaterials with essential properties like biodegradable, bio-compatibility as well cyto-compatibility etc. These properties are useful for bio-medical including wound healing applications. In this study, fibre obtained banana pseudo stem of banana plant, which is otherwise wasted, was used as a material along with chitosan and guar gum to fabricate a banana fibre-biopolymer composite patch. The physiochemical properties of the patches were examined using Fourier Transformed Infra-red spectrophotometer (FT-IR), tensile tester, Scanning Electron Microscope (SEM), contact angle tester, swelling and degradation studies. We further demonstrated that a herbal drug, Nirgundi could be loaded to the patch showed controlled its release at different pHs. The patch had good antibacterial property and supported proliferation of mouse fibroblast cells. The study thus indicates that banana fibre-chitosan-guar gum composite can be developed into an alternative wound healing material.

ОЦЕНКА СООТВЕТСТВИЯ БУРОВЫХ РЕАГЕНТОВ, ПОСТАВЛЯЕМЫХ ИЗ СЕВЕРНЫХ РАЙОНОВ КИТАЯ

The article presents the results of conformity assessment of reagents for oil well drilling, produced and supplied to Russia from China. The current state of Russian-Chinese co-operation in the field of supply of oilfield chemicals and reagents for drilling oil and gas wells is presented. It is shown that the import of xanthan gum and guar gum is necessary and alternative-free due to the lack of raw materials for the production of these types of drilling reagents in Russia. The relevance of the study is due to the current situation of sanctions pressure and trade and economic blockade by Western countries, which gives cooperation with China in various industrial areas a strategic nature. After the withdrawal of Western companies it was China that replaced huge volumes of chemical reagents for oil production, in this connection it is necessary to control Chinese chemistry in terms of efficiency and safety of application at oil and gas production facilities. The methods of viscometry, gravimetry, sieve analysis were used in this work. Two samples of xanthan resin and one sample of low viscosity polyanionic cellulose were tested. As a result of the tests it was shown that the quality of Chinese-made drilling reagents meets the requirements of Russian and international standards. In addition, new technical possibilities for viscosity determination on the rotational viscometer have been revealed, which consist in the possibility of using a rotational viscometer equipped with a torsion spring f1, instead of a rotational viscometer equipped with a torsion spring f0.2, specified in the international standard ISO 13500. The work also shows the unlikelihood of organochlorine compounds in the composition of polyanionic cellulose and xanthan gum.

Extraction, Phytochemical Screening and HPTLC Analysis of Fenugreek Gum for Analysis of Different Phytoconstituents

Fenugreek gum is a natural polysaccharide that has been explored for various biomedical applications. The present study investigated the phytoconstituent profile of fenugreek gum, revealing it as a potent source of diverse bioactive compounds. The analysis encompassed steroids, fats and oils, alkaloids, proteins, saponins, tannins, phenolics, flavonoids, and carbohydrates. Extraction using methanol and aqueous solvents demonstrated the highest concentration of phytoconstituents, underscoring the efficacy of these solvents in isolating bioactive components from fenugreek. Further exploration involved the determination of Rf values and percentage area in chloroform, petroleum ether, and chloroform extracts, providing a comprehensive identification of the mixture’s components. The results suggested a rich and varied chemical composition in fenugreek gum, offering potential applications in diverse fields owing to the presence of steroids for physiological effects, fats and oils for nutritional benefits, alkaloids with potential pharmacological properties, proteins for cellular functions, saponins for their soap-like properties, and tannins and phenolics as antioxidants. Additionally, the presence of flavonoids and carbohydrates adds to its nutritional and medicinal value. The study’s findings contribute valuable insights into the phytochemical composition of fenugreek gum, shedding light on its potential applications in the realms of medicine, nutrition, and industry. The identification of optimal extraction methods and the characterization of phytoconstituents lay the foundation for future research and utilization of fenugreek gum as a versatile and valuable natural resource. Overall, this investigation underscores the significance of fenugreek gum as a rich repository of bioactive compounds with diverse potential applications across various domains.

Bio-based Eucommia ulmoides gum composites for high-performance engineering tire applications

In this work, bio-based Eucommia ulmoides gum (EUG)/natural rubber (NR)/styrene-butadiene rubber (SBR) composites are successfully fabricated through physical blending. The influence of sulfur (S) and EUG content on the crystallization characteristics, static and dynamic mechanical properties of the composites is systematically investigated. Furthermore, the impact of the cross-linking network structure on the crystallization behavior of EUG is examined, and the application of EUG/NR/SBR composites in engineering tires is explored. The results reveal that with the increasing of EUG content, the composites exhibit enhanced wear resistance and cut resistance, as well as reduced heat generation and rolling resistance. Specifically, in comparison with NR/SBR composites, the dynamic temperature rise, wear resistance, and dynamic cutting amount of EUG/NR/SBR (20/40/40) composites decreased by 14.7%, 17.1%, and 11.2%, respectively, while the fatigue life of the composites improves by 33%. This work provides valuable guidance for fabricating and applying high-performance bio-based EUG composites in engineering tires.

Preparation and emulsification properties of cationic starch-xanthan gum composite nanoparticles.

In this work, nanoparticles were prepared by the composite of cationic starch (CS) and xanthan gum (XG) through gelatinization and alcohol precipitation for the first time. Physicochemical properties, micromorphology, and emulsification properties of CS/XG nanoparticles were measured. SEM showed that after compositing with XG, the diameter size of the CS/XG nanoparticles was increased from about 50nm to 150-300nm. FT-IR, XRD and 13C CP/MAS NMR confirmed that XG was successfully complexed with CS. Besides, the visual observation indicated emulsions stabilized by CS/XG nanoparticles had excellent storage and thermal properties. Additionally, the rheological and stability results of emulsions show that pH and NaCl had effects on the rheological and stability properties of emulsions, which means that the prepared emulsions had environmental responsiveness. Thus, this work provides an efficient method to prepare CS and GX composite nanoparticles with efficient emulsifying properties.

Impact of dispersion conditions and coacervation on fibril formation in gellan gum-potato protein mixtures

The development of plant-based meat analogs as sustainable alternatives to traditional meat products is a major focus of the modern food industry. Meat-like structures and textures can be fabricated from protein-polysaccharide mixtures using soft matter physics approaches. In this study, we investigated the effects of gellan gum dissolution properties on the fiber formation and textural properties of potato protein-gellan gum composites. We hypothesized that the fibrous structures naturally formed by powdered gellan gum when it is dispersed in water may be useful for creating meat analogs. Zeta-potential measurements showed that cationic potato protein and anionic gellan gum formed electrostatic complexes. In the presence of excess protein, complexation of gellan gum and potato protein resulted in the formation of fibrous structures. Fiber formation and thermal gelation of the protein-polysaccharide composites depended on whether salt (100 mM NaCl) was added, and whether it was added before or after the gellan gum. The shear modulus of heat-set composite gels was higher in the presence of salt than in its absence, which was the opposite to what was observed for pure gellan gum gels. Moreover, adding salt before the gellan gum led to stronger heat set gels than adding it after the gellan gum. These effects were mainly attributed to the ability of the mineral ions to screen the electrostatic interactions between the biopolymer molecules, thereby altering their packing behavior. Our findings suggest that controlling the dispersion and coacervation of gellan gum and potato protein can be used to create fibrous structures, which may facilitate the development of plant-based meat products with improved textural attributes.

Preparation and characterization of sisal fibre reinforced sodium alginate gum composites for non-structural engineering applications

Abstract In this work, untreated/treated sisal fibre (SF)-reinforced sodium alginate composites for three different concentrations (1.5%, 2%, and 2.5%) are fabricated by the hand lay-up method, and the variations in mechanical properties such as tensile strength, flexural strength, and impact strength are studied. The treated and untreated composites are analysed and compared using scanning electron microscope to study the surface morphology. Energy-dispersive spectroscopic analysis is carried out to evaluate the elemental compositions. Fourier transform infrared spectroscopic analysis is conducted to determine the interaction between fibres and matrix material. The thermal observations such as differential scanning calorimetry and thermogravimetric analysis showed only slight variations between the untreated and treated SF composites. The results of this work indicate that untreated sample with the maximum sodium alginate gum concentration had significantly enhanced mechanical properties and low moisture absorption rate. Biodegradation test inferred that it was superior for the treated fibre rather than the untreated fibre composites. The primary objective of this work is to assess the suitability of these composites for non-structural engineering applications.

Polyaniline/Cashew Gum Composite Electrosynthesized on Gold Surface in Aqueous Acid Medium for Ammonia Colorimetric Detection

The electrosynthesis of polyaniline (PAni) and cashew gum (CG) composite was successfully performed by electrochemical methods (potential scanning and constant potential) in terms of pH, aniline (Ani), and polyelectrolyte concentrations. Study aim was to investigate the performance of a polyaniline-based ammonia sensor under different concentrations of ammonium gas, evidencing a color change from green to blue as in the presence of gas in a sensitive and reversible process. Films grown by cyclic voltammetry and chronoamperometry showed a cauliflower-like morphology, and a visual analysis detected a limit of 0.015 and 0.010 mol l−1, respectively. The sensor demonstrated a fast response time of 20 s, a low detection limit, with a short regeneration time of less than 1 min at room temperature. This polyaniline-based sensor is shown as a portable, sensitive, dimensionally flexible, and cost-effective alternative for food packaging and other devices. The findings of this study contribute to the development of advanced ammonia detection technology.

Gum tragacanth-mediated synthesis of metal nanoparticles, characterization, and their applications as a bactericide, catalyst, antioxidant, and peroxidase mimic

Abstract Among biogenic methods employed for synthesizing various nanoparticles (NPs), gum tragacanth (TGC)-mediated NP production is important. The gum TGC not only qualifies the principles of green chemistry but also embraces unique qualities. In this perspective, the current review concentrates on the composition, uses, and exploitation of gum towards synthesizing metal NP of silver (Ag), gold (Au), palladium (Pd), platinum (Pt), and their characterization (UV-visible absorption spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscopy). In addition, applications of synthesized NP as a bactericide, catalyst, antioxidant, and peroxidase mimic are emphasized. Ag NP (13 nm) showed antibacterial action against Gram-negative and Gram-positive bacteria at 2–12 μg‧mL−1. The exploitation of Ag NP as a bactericide makes it a candidate of choice for medicinal and pharmacological applications. The catalytic activity of Pd NP (14 nm) demonstrated borohydride reduction of methylene blue. The gum reduced/capped metal and metal oxide NP serve as redox and photocatalysts for the remediation of toxic pigments and dyes in industrial effluents. At 15 μg‧mL−1, Pd NP exhibited 1,1-diphenyl-2-picrylhydrazyle radical scavenging activity (95.8%) and served as an artificial enzyme mimic for colorimetric sensing of hydrogen peroxide. The industrial applications of other TGC-based nanocomposites, such as heavy metal sorption, wound dressing, drug carrier, tissue engineering, etc., are mentioned.

EVALUATION OF VATERIA INDICA MODIFIED GUM AS A RELEASE RETARDANT MATRIX IN THE TABLET DOSAGE FORM

Objective: A natural gum from Vateria indica was investigated as a novel matrix-forming material for sustained drug delivery using diclofenac potassium as a model drug. Methods: In the current investigation, we formulated a matrix tablet using chloroform soluble gum portion of Vateria indica modified gum (VIMG) as a natural matrix-forming agent. It was used with a drug-polymer ratio ranging from 1:0.5 to 1:4.5. The pre-compression study of the powder blends was done by calculating bulk density, tapped density, angle of repose, and carr’s index, compressibility, and hausner’s ratio. The tablets were prepared by direct compression method and prepared tablets were evaluated and were found according to the official guidelines by pharmacopeia. The in vitro drug release was carried out using USP paddle type II apparatus and the release was found to be sustained. Results: The formulation VIMG-5 containing drug: polymer ratio 1:2.5 showed the 96.26%±1.73 drug release in 12 h. The results showed that chloroform soluble fraction of Vateria indica can be used as a drug release modifier to delay the rate of drug release, which depended on the amount of gum composition, as the concentration of gum was increased, there was sustained the drug release with promising accelerated stability. Conclusion: The evaluation studies on sustained release matrix tablets using Vateria indica chloroform soluble portion of gum as natural material demonstrate the multivariate applications such as matrix forming, binder, and release retardant of the gum in tablet formulation.

A review on: medicated chewing gum

Chewing gums are the type of mobile drug delivery systems. It is useful by means of administering drugs either locally or systemically through, the oral cavity. The treated chewing gum has through the times gained adding acceptance as a medicine delivery system. As compare to that chewable tablets treated epoxies aren't supposed to be swallowed and it can be removed from the point of operation without resort to invasive means and treated biting gum. MCG is solid, single cure medication. The end of this review is to gives an overview of gum composition, manufacturing process, and characterization. Due to the failure of studies concerning the evaluation of the mechanical parcels of MCGs, lesser effect was placed on the available performance tests and procedures for the estimation of their mechanical and textural parcels. It can be used either for original (mucosal) treatment of mouth complaint or for systemic (transmucosal) delivery by direct intra oral immersion through the buccal mucosa.