The report summarizes ongoing research to screen new materials for control of lepidopterous larvae, especially pickleworm (PW), on squash. Experiments were conducted at the University of Florida Gulf Coast Research and Education Center in Wimauma, FL. Plots were seeded 19 Feb and re-seeded 20 Mar, 1.5 ft apart within the row on 8-inch-high and 32-inchwide beds of Myakka fine sand covered with white polyethylene mulch. Each plot consisted of a single 21 ft-long row spaced 9 ft end to end and 10 ft apart. Treatments were replicated four times in a RCB design. Spray treatments were applied with a 2.5 gal, hand-held CO2-powered sprayer that was fitted with a D-5 disk and #45 core and was operated at 60 psi. Applications were made on 2, 8, 23, and 29 Apr at 60 gpa and on 13 May at 90 gpa. The drip application of Synapse was made on 10 Apr through a single drip tube per plot with 0.25gal/h (10 psi) emitters spaced 12 inches apart. Applications were made at 10 psi at a rate of 400 gpa, and the drip system was then flushed with another 530 gpa. Laboratory bioassays were conducted using approximate 2 instars of the corn earworm (CEW) and PW. For each bioassay, 3 leaves that had been tagged prior to spraying were collected and a single disk 1 inch diameter was cut from each and placed individually in Petri dishes with water moistened filter papers. Two to 3 laboratory-reared larvae, depending upon availability, were placed on each disk and mortality checked 1-6 days later. Bioassays for the CEW were conducted 1, 7 and 15 days after the second foliar treatment (DAT2) and 7 days after the third treatment (DAT3). Bioassays for the PW were conducted 6 days after the first treatment (DAT1), 7 and 14 DAT2, 6 DAT3, and 2 days after the fourth treatment (DAT4). Ten plants of each plot were harvested 15, 17, 22, 25, 28 Apr, 1, 5, 9, 13, 16, 20 and 23 May and undamaged fruit were counted and weighed and pickleworm damaged fruit were counted. The data were totaled over all harvests. Data were analyzed with analyses of variance and mean separation used the LSD.