Procedural Guidelines Research Articles

Турбулентные и ламинарные типы отечественного уголовного судопроизводства: гипотезы и концепции

All domestic types of criminal procedure are divided into turbulent (adversarial and mixed) and laminar (accusatory and investigative) in scientific article. The hypothesis that there is a certain relationship between the prevailing type of criminal procedure and its inherent types of criminal prosecution was made. The legal family of an analyzed country lies in the basis for the construction the technology of criminal procedure. But, despite the single basis, the type of criminal process created on its basis always has national characteristics and only its inherent concepts. Each type has its own unique production order. The author defends the concept of evolution types from one to another, taking into account the scientific paradigm and the worldview of society of a particular historical period. The procedural guideline for development is the ideal model of criminal procedure which is adjusted, supplemented and improved for each milestone of the procedural dialectic acting as a kind of de lege ferenda. The hypothesis about the expediency of designing a convergent type of criminal process which will allow for optimal correlation of claim and search technologies, will improve the methodological and theoretical foundation of criminal procedural activity was expressed in scientific article. The increasing the quantitative participation of citizens in the dispensation of justice should play the leading role in this typological transition.

18F-FDG PET/CT in Inflammation and Infection: Procedural Guideline by the Korean Society of Nuclear Medicine

18F-FDG PET/CT in Inflammation and Infection: Procedural Guideline by the Korean Society of Nuclear Medicine

Legal Study of the Role of the Honorary Board of Election Administrators in Realizing Democratic Elections

The primary goal of this research is to evaluate the role of the Honorary Council for the Implementation of Elections in prosecuting election organizers who break the code of ethics, as well as to understand how the DKPP imposes sanctions on election organizer members who breach the code of ethics. This study employed normative legal research. The author's study reveals that where Article 1 paragraph (24) indicates, "The Election Organizer Honor Council, hereinafter abbreviated as DKPP, is an entity in charge of dealing with infractions of the Election Organizer's code of ethics. The provisions that mention the sanctions for violations of the election organizer's code of ethics are regulated in DKPP Regulation No. 1 of 2021 concerning the Second Amendment to the regulation of the Election Organizer Honorary Council No. 3 of 2017 concerning Procedural Guidelines for the Code of Ethics for General Election Organizers Article 31 paragraph 4 indicates that if the DKPP's finalization judges that the Respondent and/or Reported Party breached, the DKPP imposes sanctions in the form of a written warning, temporary dismissal, or permanent dismissal. Thus, it is determined that the implementation of the code of ethics in Indonesia, particularly in the election management body, DKPP, must prevent violations of the code of ethics committed by election organizers in order to ensure democratic elections.

Essential Elements for Implementing AI Tools in Elementary School: A Systematic Literature Review

The global use of Artificial Intelligence (AI) has attracted considerable attention, and its integration into educational systems is a priority that warrants further exploration. In collaboration with UNESCO, numerous organizations have proposed parameters advocating for the inclusion of AI in basic education systems. A systematic literature review (SLR) was conducted to identify these parameters from the existing research. Although these parameters have been mentioned in some studies, they are generally not prioritized in the research landscape. AI tools are primarily used to support students, while teachers typically employ a pedagogical approach centered on in-class activities. Additionally, essential conditions related to research requirements and involvement from the private and third sectors showed consistent adherence across the examined studies. However, it was found that only 52% of the studies included an ethical declaration regarding the data collected by AI during research development, especially regarding studies involving children. This review provides a guide for educational communities looking to enhance pedagogical practices through AI integration into their educational environments, but who may be uncertain about where to begin. Questions related to AI modality selection, pedagogical relevance, ethical considerations, and procedural guidelines for integrating AI into curricula are addressed through the insights provided in this review.

ANALISIS RISIKO K3 DENGAN METODE HIRARC PADA PROSES BENDING SEMI FINISH PLATE BUMPER HM400 KOMATSU DI PT. KHARISMA LOGAM UTAMA BEKASI

The increasing competition in the industrial sector has driven companies to enhance productivity while maintaining the safety standards. PT. Kharisma Logam Utama (KLU), a manufacturing company specializing in metal and machinery components, is a key partner for PT. Komatsu Indonesia, producing parts for heavy equipment such as the KOMATSU HM400 articulated dump truck. The bending process of semi-finished plates, an essential step in bumper production, poses significant risks to worker safety. This study aims to analyze occupational health and safety (OHS) risks using the Hazard Identification, Risk Assessment, and Risk Control (HIRARC) method. Data collection was conducted through direct observation and interviews over August to September 2024. The findings highlight that most risks in the bending area are categorized as Level II (acceptable with monitoring), constituting 45% of identified activities. Level I risks, deemed acceptable, made up 35%, while Level III (problematic, requiring immediate action) constituted 15%. The highest risk level, IV (unacceptable), accounted for 5% and demands urgent corrective measures due to potential serious injuries or fatalities. The analysis identified mechanical hazards such as cuts, pinches, and material falls as prevalent. Implemented controls included personal protective equipment (PPE) like anti-impact gloves, safety boots, and safety goggles, alongside procedural guidelines. The application of the HIRARC method proved effective in prioritizing risk mitigation measures and improving workplace safety, ultimately contributing to a safer production environment.

Advances and Challenges in Gene Therapy for Neurodegenerative Diseases: A Systematic Review.

This review explores recent advancements in gene therapy as a potential treatment for neurodegenerative diseases, focusing on intervention mechanisms, administration routes, and associated limitations. Following the PRISMA procedure guidelines, we systematically analyzed studies published since 2020 using the PICO framework to derive reliable conclusions. The efficacy of various gene therapies was evaluated for Parkinson's disease (n = 12), spinal muscular atrophy (n = 8), Huntington's disease (n = 3), Alzheimer's disease (n = 3), and amyotrophic lateral sclerosis (n = 6). For each condition, we assessed the therapeutic approach, curative or disease-modifying potential, delivery methods, advantages, drawbacks, and side effects. Results indicate that gene therapies targeting specific genes are particularly effective in monogenic disorders, with promising clinical outcomes expected in the near future. In contrast, in polygenic diseases, therapies primarily aim to promote cell survival. A major challenge remains: the translation of animal model success to human clinical application. Additionally, while intracerebral delivery methods enhance therapeutic efficacy, they are highly invasive. Despite these hurdles, gene therapy represents a promising frontier in the treatment of neurodegenerative diseases, underscoring the need for continued research to refine and personalize treatments for each condition.

Unlocking the potential of melting calorimetry: a field protocol for liquid water content measurement in snow

Abstract. Melting calorimetry, a classic experiment often conducted in high-school chemistry laboratories, holds significant untapped potential for scientific applications beyond its educational context. Traditionally, this technique has been applied to measure the liquid water content in snow using two different formulations: melting calorimetry and freezing calorimetry. In contrast to freezing calorimetry, which is considered the reference method for measuring liquid water content, melting calorimetry has been perceived as prone to generating significant inaccuracies. This research revisits the formulations for both melting and freezing calorimeters to assess volumetric liquid water content in snow. By incorporating the calorimetric constant, we account for heat exchange with the calorimeter, a critical factor often neglected in melting-calorimetry experiments. This paper identifies the most effective and least uncertain method for determining this constant. A central contribution of this work is the introduction of a framework for estimating uncertainty in volumetric liquid water content measurements, adhering to established guidelines for uncertainty expression. This novel framework allows us to revisit past mathematical analyses and demonstrate that melting calorimetry delivers reliable measurements with an uncertainty 0.25 % greater than freezing calorimetry. Notably, despite this slightly higher uncertainty, melting calorimetry offers significant practical advantages for field applications. Moreover, we show how the proposed uncertainty framework can be expanded beyond instrumental uncertainty and also take into account the variability from environmental factors and operators, providing a more comprehensive characterization of the uncertainty. By exploiting the proposed uncertainty framework, we finally conduct an in-depth analysis for the optimal tuning of the experiment parameters. This analysis culminates in a robust field protocol for melting calorimetry that transcends commonsense procedural guidelines. Strict adherence to this protocol will maximize measurement accuracy. Applied in field tests in Italy and Switzerland, the melting calorimetry was demonstrated to accurately track the wet front penetration in the snowpacks, producing results comparable to independent dielectric measurements. These findings highlight the accuracy and the practical advantages of melting calorimetry as a reliable field tool for quantifying snowpack liquid water content. Melting calorimetry can potentially serve as a valuable tool for the independent calibration and validation of proximal and remote sensing techniques used for liquid water content retrieval.

Effect of Salvadora persica chewing sticks on maxillary central incisors crown-root angulation in Western-Asian population & correlation with Collum angle on 3D CBCT images

The main aim of the study was to identify the Collum angle classification for maxillary central incisors among individuals use vs not-use chewing sticks which could have beneficial role for immediate implant placement in respective individuals. Additionally, to identify the root-crown positioning and angulation in the Western Asian Saudi Arabian population for chewing sticks user’s vs non-users in order to develop guideline for the prosthetic procedures using Cone beam computed tompography (CBCT). A total number of 380 CBCT scans were included in the study for both of the groups based on the inclusion criterion of the patients reporting to the Dental OPD of Riyadh Elm University. The data was analyzed using 3D planner dental imaging software. Initially the teeth were classified based on root position in relation to facial plate of alveolar bone using Jung et al. classification. Additionally, the Collum angle and the root angulation of the maxillary central incisors was evaluated. The data was analyzed using one-way Anova with post-hoc Tuckey-Kramer test for pair-wise comparison. As per the Jung et al. classification, majority of the roots were observed with buccal placement. Based on the Collum angle classification majority of the maxillary central incisors were observed with facial placement (n=170), specially subtype I (n=78). But the root angulation was observed to be independent of Collum angle. Thus, it can be concluded, unlike root angulation, Collum angle has a correlation with root positioning. The angle for the individuals using chewing sticks of Salvadora Persica was similar to the individuals not using the miswak. Collum angle is correlated in all classified position of root. But the root angulation is independent of classification varies between miswak and non-miswak users.

Actual clinical practice pattern in SWL after COVID-19 era: a critical evaluation from different aspects.

To outline the current status of Shock Wave Lithotripsy (SWL) in stone treatment and the changes in the mode of application after the COVID-19 pandemic along with critical factors affecting the clinical practice of this particular procedure. This study targeted national and international urology experts who could share and contribute their experiences and perspectives on SWL practices after COVID-19 era. Approximately 650 urology specialists were invited to participate in the survey based study via Google Forms. Participation was voluntary and 398 of the invited participants completed the survey, yielding an acceptable response rate of approximately 61.23%. This survey highlights significant findings that shed light on the changes in clinical SWL applications. Nearly half of SWL procedures are performed by technicians or nurses instead of experienced urologists, potentially affecting the proper application and outcomes of the procedure. SWL seemed to be applied on a guideline (GL) indications based manner by the majority of the participants. Fluoroscopy remains still as the most commonly used method for radiological assessment, underscoring the necessity to teach sonography applications to younger urologists. Key reasons for the limited clinical application of SWL include the absence of lithotripters in the departments, high lithotriptor costs and significantly lower reimbursement rates compared to PNL and fURS modalities. Finally, an increase in SWL utilization rates has been observed post-COVID-19, highlighting its certain advantages realized during this period. These findings provide important insights into the role of SWL in stone treatment and the main factors influencing its clinical application practices. Although the popularity of SWL in the management of urinary stones is being stated to decline particularly in the last two decades, data obtained in this survey emphasized well that it is still a viable option especially for stones smaller than 15mm. Our findings highlight the enduring relevance of SWL in contemporary stone therapy protocols in the context of COVID-19, where outpatient, non-invasive procedures are preferred. In addition to the consideration of certain factors affecting the rate of its application in clinical practice, to achieve high success rates with minimal complications in SWL, strategic patient selection and adherence to procedure guidelines seem to be crucial.

The Transformation of Acupuncture Practice Using Ultrasonography: Expert Opinions.

The rapidly growing use of ultrasound in South Korea has revolutionized the real-world application of acupuncture, making it a safer, more accurate treatment. However, little is known about the challenges Korean medicine doctors (KMDs) encounter, as well as the procedures and resources necessary for hygienic, safe ultrasound-guided acupuncture. This study aimed to investigate the purpose, indications, and procedure for ultrasound-guided acupuncture in Korean medicine (KM) practice and the challenges KMDs encounter in using ultrasonography. Eleven KMDs with expertise in practicing or teaching ultrasonography were consulted in detail. The purpose of ultrasonography in real-world practice, the overall process, resources utilized in ultrasound-guided procedures, and the unaddressed needs of KMDs were investigated. Ultrasound guidance, employed for various diseases in KM practice, is crucial for pharmacopuncture and acupotomy to increase accuracy and safety. Ultrasoundguided acupuncture involves covering the probe, putting on sterile gloves, and scanning with disinfectants, though the exact steps vary among experts. They also suggested that a lack of insurance coverage was a common obstacle for KMDs utilizing ultrasonography. Acupuncture with ultrasound guidance has become a prevalent procedure in South Korea. Standard procedure guidelines and insurance coverage for ultrasonography used for acupuncture procedures are essential to ensure safe, accurate procedures.

The impact of root end filling material type and the application of bone graft on healing of periapical tissues after endodontic microsurgery (a clinical randomized controlled trial)

To evaluate the effect of combining different bioactive root-end filling materials with composite bone graft (xenogeneic mixed with autogenous bone fragments) on the healing process of periapical tissues after endodontic micro-surgery procedure. In this triple-blinded clinical trial, 56 patients were divided into 2 main groups (28 each) according to the root-end filling material and 2 subgroups according to the presence or absence of the composite bone graft material. Group I: MTA root-end filling (n = 28) in which there are Sub-group A: without bone graft (n = 14) and Sub-group B: with composite bone graft (n = 14). Group II: TotalFill root-end filling (n = 28) in which there are Sub-group A: without bone graft (n = 14) and Sub-group B: with composite bone graft (n = 14). Healthy patients whose ages range from 20 to 50 years with small-to-medium size radiolucency in CBCT related to single-rooted maxillary teeth were included in this study. Patients were assigned a number starting from 1 to 56 and were randomly allocated to four test groups (2 main groups and 2 sub-groups) following simple randomization procedure guidelines described by IBM SPSS V23 (IBM USA) statistical analysis software. This trial was triple-blind where the patient, the outcome assessors, and the main operator were blinded to the applied intervention. Every patient was evaluated clinically and by CBCT at two main observation periods: presurgical and 12-month post-operative. They were also examined and evaluated clinically and radiographically through periapical x-rays after one week, three, and six months. Statistical analysis was performed with IBM SPSS Statistics for Windows Version 23.0. Armonk, NY: IBM Corp. Of the 56 patients enrolled in the study, 49 patients were available for the final analysis. All groups showed no statistically significant differences with regard to healing or success rates at the 12-month follow-up mark. No adverse effects were encountered. Results showed that high success rates were achieved using MTA and TotalFill in the healing of periapical lesions after endodontic surgery. The addition of bone graft in small-to-medium size lesions did not affect the success rate of endodontic surgeries.

Orthopaedic Provider Coding Trends After 2021 Changes to the Current Procedural Terminology Evaluation and Management Coding Guidelines: A Retrospective Cohort Study.

The goal of this study was to determine changes in orthopaedic coding practices between December 2020 and January 2021 after training providers on the 2021 Current Procedural Terminology Evaluation and Management (E&M) Centers for Medicare and Medicaid Services guideline changes. Outpatient encounters in December 2020, January 2021, December 2021, and January 2023 were grouped by provider and E&M code level. The codes used for established patients were 99211, 99212, 99213, 99214, and 99215, ordered from low to high-complexity visits. The codes used for new patients were 99201, 99202, 99203, 99204, and 99205 also in order of complexity from low to high. A statistically significant increase was noted in coding levels for both new and established patients from December 2020 to January 2021 (P < 0.001). For new patients, there was an increase in level 4 codes from 16% to 54% and an increase in level 5 codes from 3% to 6% (P < 0.0001). This notable increase in level 4 and 5 codes was maintained through 2 years (January 2023) for new patients. A statistically significant increase was noted in coding levels for both new and established patients since E&M guideline changes. This change was maintained for 2 years.

Aortic valve replacement in younger patients with aortic valve insuffienciency

Aortic valve replacement is the common treatment of choice for severe aortic valve insufficiency (AI). AI is often caused by aortic root dilatation which leads to valve incompetence despite structurally normal valve leaflets. For this condition, aortic repair surgery with ring annuloplasty is considered a potentially superior option. Despite the availability of different annuloplasty rings, no guidelines for the surgical procedure nor the choice of annuloplasty ring exist. In this review, we outline the surgical treatment using valve-preserving procedures as an alternative to conventional aortic valve replacement.

Diagnostics and Multi-criteria Analysis of Methods for Drying Buildings After Flooding. Case Study

This article presents guidelines for moisture and mycological diagnosis procedures for buildings after flooding. This paper proposes a division of the diagnostic procedure according to the medium of action and collects and presents methods for drying building elements. 54 companies dealing with drying were analyzed. The task of dehumidification is to use various methods to reduce the moisture level of building partitions to the equilibrium moisture level. An analysis of dehumidification methods in terms of ease of application, duration of the dehumidification process and level of structural interference is presented. In Poland, there are no guidelines formulated in legal acts or instructions regarding the procedure for moisture diagnostics and nor drying. It was noted that in situ studies cannot always lead to determining the actual values of mass moisture and thus to creating a real model of partition drying.

Behavior, attitude, perception, and knowledge regarding fertility preservation among Chinese pediatric oncologists: a survey in China.

Clinical specialists are supposed to inform childhood cancer patients of infertility risk and conduct fertility preservation (FP). However, little is known about whether doctors in China are fully prepared. This study aimed to investigate behavior, attitude, perception, and knowledge regarding FP among pediatric oncological specialists in a nation wide survey, to set the stage for improvements in current clinicalpracticepatterns. This study was conducted on physicians and surgeons specialized in pediatric oncology using a questionnaire through theWeChat platform. The behavior, attitude, perception, and knowledge were assessed by Likert questions and results were quantified to obtainscores. Data were then described and analyzed using R and GraphPad. Totally 373 specialists in pediatric tumors were included in the analysis. Hematologists, oncological surgeons, and reproductive medicine specialists won most trusts to be responsible for FP job. Most respondents did not have habits of delivering FP information or cooperating with FP specialists during treatment though they were well equipped with FP knowledge and desired for uniform national guideline for FP procedures. The severity of illness was regarded as the primary barrier of FP delivery. When a doctor was more educated and experienced, he was more likely to have better performance in FP. The total score, the knowledge score, and the single score concerning frequency of patients' inquiry showed aggregational trend on geographic distribution. Chinese pediatric oncologists demonstrated unsatisfactory practice behaviors based upon this self-reporting survey, although their attitude towards FP was generally positive.

Transvaginal cervical cerclage – How well do surgeons assess their own procedures?

IntroductionIn women with cervical incompetence, transvaginal cerclage may help prevent preterm birth. However, training for this procedure poses challenges due to the low number of cases and difficulties in visualizing the operative field. Furthermore, the objective criteria for a successful cerclage procedure are not well-described. Quality assessment relies heavily on self-assessment rather than objective criteria and feedback. To address this issue, training on a simulator may offer a solution. We aimed to objectively assess surgical performance and compare it to the self-assessed performance in transvaginal cerclage procedures. Materials and methodsDuring the Nordic Federation of Obstetrics and Gynecology (NFOG) congress in 2023, surgeons proficient in transvaginal cerclage procedures performed a transvaginal cerclage on a simulator. To compare the observed and self-assessed outcomes we obtained measurements on the cerclage height and number of bites from the detachable cervix, and from computed tomography scans we analyzed suture bite depth, reduction of cervix surface area, and whether cerclages had perforated the cervical canal. The same outcomes were self-assessed by each participant after the cerclage procedure. We visualized the continuous paired data in a Bland-Altman plot and compared these data with a paired t-test. Paired binary data was analyzed using McNemars test. Results29 participants from eight different nationalities performed one transvaginal cerclage each. The mean height of the cerclage was 26.8 mm (SD 9 mm) and mean depth was 6.5 mm (SD 1.9 mm) across a mean of 4.1 (SD 0.8) bites. The mean reduction of the cervix surface area was 7.6 % (SD 5.9 %). Two sutures perforated the cervical canal. The participants significantly underestimated the height of their cerclage with a mean difference of 6.0 mm (95 % CI 2.1–9.9), (p 0.002), between the observed and the self-assessed height, but otherwise revealed good self-assessment of their performed procedure. ConclusionsOverall, the experienced cerclage surgeons showed a genuine insight into their surgical performance of a transvaginal cerclage. These results could warrant development of a procedural guidelines with objective measures, now reassured that surgeons are capable of self-assessing their procedures.

Drug supply management at first-level public health facilities: Case of Pyay District, Myanmar.

First-level public health facilities (PHFs) serve as primary providers of essential medicines, necessitating critical attention to drug availability and quality assurance. This study aimed to examine the status of functional areas within the drug supply chain management framework and assess the overall capability maturity at first-level PHFs. The cross-sectional study was conducted among 183 drug store sites from six townships of Pyay District. Only situational analysis was exercised to determine the existing situations. The overall capability maturity was determined according to the definitions of levels of the Capability Maturity Module Tool. 58.47% lacked formal drug supply management training, with 23.5% not undergoing performance reviews. Drug forecasting predominantly relied on a pen-paper system (91.6%) and factors like patient load (87.39%), drug consumption (85.71%), and disease prevalence (64.71%). Store site analysis revealed that 65.03% exhibited marginal capability, lacking standardized drugstores and employing unstandardized procedures. Storage practices varied, with 48.69% storing drugs conveniently and others categorizing them by drug type (32.79%) or using the first-expired-first-out system (40.98%). Approximately 42.69% reported having expired drugs. Concerning transportation costs, 37.16% incurred expenses exceeding 20,000 Kyats per time, with management staff often covering the costs. Waste management methods included burial pits (49.18%), incineration (62.84%), and sharp pits (55.19%). A majority (78.14%) used safety boxes, and 57.38% implemented a color-coded system for waste bins. The logistics management information system was entirely paper-based (100%). On average, assessments of drug quality conditions and physical damages scored 46.51% and 48.20%, respectively. The overall supply chain maturity at first-level public health facilities is at a marginal capability level (36.35%). While some basic drug supply chain management procedures were in place, they were not consistently followed, and many systems remain manual. The findings underscored significant inconsistencies in the management functions of supplied drugs, with poor adherence to Standard Operating Procedure guidelines.

Navigating ethical challenges in online wildlife trade research.

The surge in internet accessibility has transformed wildlife trade by facilitating the acquisition of wildlife through online platforms. This scenario presents unique ethical challenges for researchers, as traditional ethical frameworks for in-person research cannot be readily applied to the online realm. Currently, there is a lack of clearly defined guidelines for appropriate ethical procedures when conducting online wildlife trade (OWT) research. In response to this, we consulted the scientific literature on ethical considerations in online research and examined existing guidelines established by professional societies and ethical boards. Based on these documents, we present a set of recommendations that can inform the development of ethically responsible OWT research. Key ethical challenges in designing and executing OWT research include the violation of privacy rights, defining subjects and illegality, and the risk of misinterpretation or posing risks to participants when sharing data. Potential solutions include considering participants' expectations of privacy, defining when participants are authors versus subjects, understanding the legal and cultural context, minimizing data collection, ensuring anonymization, and removing metadata. Best practices also involve being culturally sensitive when analyzing and reporting findings. Adhering to these guidelines can help mitigate potential pitfalls and provides valuable insights to editors, researchers, and ethical review boards, enabling them to conduct scientifically rigorous and ethically responsible OWT research to advance this growing field.

Exploiting the Applicability of Polytetrahydrofuran-Modified Polyester for the Fabric Phase Sorptive Extraction of Doxycycline from Human Urine.

In this report, a polytetrahydrofuran-coated polyester fabric phase sorptive extraction (FPSE) for the determination of doxycycline in human urine was described. The sol-gel polytetrahydrofuran sorbent proved to be superior against other sol-gel coated cellulose and polyester membranes tested. The effect of the extraction parameters including membrane surface area, sample pH and volume, salt concentration, extraction time, stirring rate, etc., on the extraction efficiency of the analyte was studied using the "one-factor-at-a-time" (OFAT) and Box-Behnken design approaches. The analytical method proposed was validated in compliance with FDA guidelines for bioanalytical procedures. The method was linear in the determination range of 100-5000 ng/mL with the determination coefficient of 0.9953. The limit of detection (LOD) and the lower limit of quantification for doxycycline was 17 and 100 ng/mL, respectively. The relative recoveries for intra-day and inter-day studies ranged from 98.5-112.2% and 89.6-96.8%, respectively. The relative standard deviation was lower than 14.7% in all cases, exhibiting good precision. The sol-gel polytetrahydrofuran-modified FPSE membranes were reusable for at least 30 times. The greenness of the developed method was evaluated using Sample Preparation Metric of Sustainability (SPMS) and Blue Applicability Grade Index (BAGI) metric tools. Finally, the analytical scheme was successfully employed for the quantitation of urinary doxycycline collected at various time points following the administration of doxycycline-containing tablets.

The Concept of Ideal Lips of Caucasian Female: An Anthropometric Analysis of the Lower Third of the Face.

The demand for lip-redefining procedures has been rising in recent years, thus creating the need for reliable and detailed reference sources on aesthetic female lips. This study investigates the morphology of the lower third of the face, including the lips and jawline, of attractive young Caucasian females. A semi-automatic photogrammetric analysis of the faces of professional female photograph models (n=400) of the Caucasian race aged 18-39 was performed. Angular, linear, and surface area parameters were evaluated. A graphical summarization of the average facial shape of all analyzed attractive females was generated as an average body contours (ABC) image. The height of the lower third of the face equaled 0.32 ± 0.02 of the total facial height. The average lip width was 48.06 ± 3.34mm. The upper vermilion height was found to be significantly lower than the lower vermilion height (6.47 ± 1.36 vs. 11.64 ± 1.46mm, p < 0.01). The lip obliquity angle was found to be 1.05° ± 0.79°. The area surface of the upper lip vermilion was considerably smaller than the vermilion of the lower lip (p < 0.01). This is one of the largest studies on attractive Caucasian females' lips and lower face morphology. The data it provides, including the graphical presentation of the aesthetic lower face as an ABC image, may provide physicians with valuable guidelines for lips rejuvenation and reconstruction procedures. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .