Managing records of patient care has become an increasingly complex issue with the widespread use of advanced technologies. The vast amount of information for every routine care must be securely processed over different databases. Clinical Information Systems (CISs) address the need for a computerized approach in managing personal health information. Hospitals and public or private health insurance organizations are continuously upgrading their database and data management systems to more sophisticated architectures. The possible support of the large patient archives and the flexibility of a CIS in providing up-to-date patient information and worldwide doctors' collaboration have leveraged the research on CIS both in academic and government domains. At the same time, it has become apparent that patients require more control over their clinical data, either being results of clinical examinations or medical history. Owing to the large amount of information that can be found on the Internet and the free access to medical practitioners and hospitals worldwide, patients may choose to communicate their information so as to obtain several expert opinions regarding their conditions. Given the sensitive nature of the information stored and inevitably in transit, security has become an issue of outmost necessity. Numerous EU and US research projects have been launched to address security in CIS (e.g. EUROMED, ISHTAR, RESHEN), whereas regulatory compliance to acts such as the HIPAA has become an obligation for centers moving to CIS. This Special Issue will serve as a venue for both academia and industry individuals and groups working in this fast-growing research area to share their experiences and state-of-the-art work with the readers. Authentication techniques for CIS Authorization mechanisms and approaches for patient-centric data Public key infrastructures to support diverse clinical information environments and networks Cryptographic protocols for use to secure patient-centric data Secure communication protocols for the communication of clinical data Wireless sensor networks security Body sensor networks security CIS database security Interoperability across diverse CIS environments (national and multilateral) Government and international regulatory and compliance requirements Submission and Review All submissions will be peer reviewed by at least three experts working in those areas. Articles should be written in a style comprehensible to readers outside the specialty of the article conforming to the standards of Security and Communication Networks Journal. This special issue solely targets research areas surrounding CIS security. Submitted papers should reflect on the current state of clinical information systems; hence, preference will be given to authors whose work is directly related to CIS and not researchers attempting to connect their work on information security with CIS. The Guest Editors reserve every right to prevent conflicts of interest to the journal as required by the Editor-in-Chief and the editorial board. For manuscript submission authors should follow the guidelines described in Section ‘For Authors’ at http://www.interscience.wiley.com/journal/security. Prospective authors should submit their paper online at the above journal homepage via the ‘online submission’ link. When submitting the papers, the authors should make sure to choose the manuscript type as ‘Special Issue’, enter the ‘Running Head’ and the ‘Special Issue title’ as ‘SCN-SI-001’ and ‘CIS Security’, respectively. Manuscript Submission Due: 10 February 2008 Acceptance Notification: 10 May 2008 Final Manuscript Due: 1 June 2008 Publication: July/August 2008