The pivotal role of quantitative risk assessment in managing urban stormwater is underscored by the high spatial heterogeneity and complex non-stationarity complex of urban flooding. Conventional methods, reliant on measurable data, often fall short in accurately mapping spatial variations and gauging the full impacts of urban flooding. Addressing this gap, this study proposed a robust convolutional neural networks (CNN)-based tool, specifically designed for urban flooding risk and economic losses estimation under extreme design rainfall scenarios. Furthermore, the study validates the transferability of CNN models trained in data-abundant regions to similar but data-scarce regions, using Guangzhou as a case study for urban flooding damage prediction. The findings reveal that the most affected areas, particularly the old, densely built-up urban areas in the south-central Guangzhou, are susceptible to significant economic losses during extreme rainfall events. Notably, under the most severe scenario (Scenario 5), estimated economic losses amount to approximately $6359.91 million, with industrial and residential sectors bearing the brunt, accounting for 28.29 % and 39.94 % of the total losses, respectively. These insights are crucial for prioritizing mitigation efforts and formulating effective evacuation strategies in high-risk areas, ultimately aiding in the reduction of economic losses.