The damage behaviour of titanium alloy laser-welded seam during hot gas pressure forming was studied by experiment and simulation. The GTN damage model was used to simulate the hot gas pressure forming process of the welded blank. The evolution of the void volume fraction during the forming process was obtained. Hot gas pressure forming experiments of cup-shaped parts were carried out. The microstructure at different positions of the cup-shaped part was observed by scanning electron microscope. Results show that the damage to the weld seam during hot gas pressure forming was mainly related to the strain. The damage of the inside fillet near the flange develops most rapidly, and it easily cracks due to the large deformation during the free bulging stage. The damage on the bottom centre develops slowly at the free bulging stage. After the bottom of the cup-shaped part contacted the die, the volume fraction of damage on the bottom center continued to increase firstly and then reached to a stable value gradually. Various micro cracks were observed during the hot gas pressure forming. The volume fraction of cracks increased with the increasing strain, and the small cracks gradually grew, expanded, and merged to form larger cracks. It is important to control the maximum strain of the weld seam during the forming to avoid possible harmful damage.