Spontaneous combustion of coal not only releases toxic and harmful gases, but also may cause gas and coal dust explosions to endanger the lives of miners. The No.15 coal seam of Fusheng Coal Mine in Shanxi has a short period of spontaneous combustion and is prone to spontaneous combustion. In order to prevent spontaneous combustion of coal seams, it is proposed to use grouting to prevent fire extinguishing technology, mainly through the design of grouting system, the selection of grouting materials, the calculation of grouting parameters, the optimization of grouting technology and the selection of grouting equipment, etc. And it establishes methods for monitoring the effects of grouting zone temperature and gas composition, fire-fighting grouting accounts, etc. A series of grouting safety technical supporting measures such as grouting work system, prevention of pipe blockage, prevention of slurry running, setting of filter slurry sealing and drainage channels, etc. are proposed.