The uniform design is a new design method for investigating the experiment with many factors and levels, which can get enough experiment information with less experiment times. The advantages of uniform design are introduced in the paper, it can seek experimental points to be uniformly scattered in the experimental domain, which reduce experiment times greatly and get good experiment results. The new polymeric grouting experiment is designed by uniform design and the experiment data has been studied by regression analysis. It is proved that distinct influencing factor on grout diffusion radius are grouting pressure and permeability, but the influences of grouting time and grout temperature are smaller, their relation has been obtained through regression analysis, uniform design is efficient and credible method of experimental design by the experiment results.