The prevalence of COVID-19 in cities across the world has impacted various category of people, especially people living in slums, older persons, persons with disabilities and migrant workers. In this paper, we examine the effects of the pandemic on internal migrant workers in Accra, Ghana’s migration hotspot and measures implemented by the Government to help them cope with the pandemic. Findings showed COVID-19 has impacted internal migrants. In particular, their living conditions and health-seeking behaviour put them at risk of contracting and spreading the virus. The Government of Ghana’s response to the pandemic through lockdowns and travel restrictions exacerbated the conditions of migrants as they are trapped in poverty and unable to escape poor living conditions. While interventions to contain the virus included vulnerable groups such as internal migrants, it is recommended that Government in partnership with NGOs, civil society groups and migrant associations, commit more resources targeted at improving the economic, health and living conditions of internal migrants. In the short term, a dedicated financial support system for internal migrants is crucial to help ameliorate the impact of COVID-19.