Objectives: To determine antioxidant activity and identify bioactive compounds present in n-Hexane & Ethyl acetate extracts of stem bark of Soymida febrifuga A. Juss. Methods: In the present study stem bark of Soymida febrifuga A. Juss was powdered and subjected to Soxhlet extraction using n-Hexane and Ethyl acetate as solvents. Extracts were analysed for the presence of phytochemicals and antioxidant activity. The Bio-active compounds were identified by Gas chromatography-mass spectrometry. Findings: The qualitative analysis revealed presence of various phytochemicals. GC-MS analysis confirmed the presence of total 28 Medicinally active compounds which included Tetradecane, Hentriacontane, Octacosane, Docosane and Eicosane in n-Hexane extract. 15 Medicinally active compounds were found in ethyl acetate extract which included Purolan, 1,2-Dipropenyl cyclobutane, Hentricontane, 2,6,7-Trimethyl decane, Tetrahydrofurfuryl propionate and Decyl propanoate. Novelty: Though the phytochemical analysis of Soymida febrifuga have been performed by some research groups but there are no reports on identification of Bio-active compounds by GC-MS. The results obtained from present study confirms presence of many compounds of biological significance that warrants further biological and pharmacological study of Soymida febrifuga A. Juss as a potential herbal drug. Keywords: Soymida febrifuga; GC-MS analysis; DPPH assay; n-Hexane; Ethyl acetate