Introduction: C-reactive protein (CRP), ESR and fecal calprotectin are important non-invasive markers that have been evaluated in Crohn's disease (CD). Although both environmental and genetic factors affect these markers, studies investigating gender and racial influences on their patterns among active CD patients is lacking. Methods: A retrospective review of 191 patient charts with CD in our electronic health records database. These patients were divided into 4 groups: white males (WM, n=48), white females (WF, n=61), black males (BM, n=31) and black females (BF, n=51). Age (between 41.6-45.5 years at time of study), BMI, age at diagnosis, CRP, ESR and fecal calprotectin levels were measured at time when endoscopy revealed active disease. The CRP, ESR and fecal calprotectin levels at time of active disease (per endoscopy) were studied in the 4 groups. Results: In our cohort of CD patients, neither patient age, nor BMI were found to differ among groups. When studied in aggregate, CRP was not different among groups (one-way ANOVA), however, when WF were compared with BF, WF had significantly lower CRP levels compared to BF (4.5±0.9 vs. 2.1±0.52, p=0.0347, two-tailed student's t-test). Similarly, aggregate analysis of active ESR was not different, but again WF had highly significantly lower active ESR than BF (43.4±4.05 vs. 24.76±3.8, p=0.006). WM also had lower ESR than BM (40.75±7.4 vs. 18.5±1.76), this did not reach statistical significance, (p=0.1497). Similarly, WF had lower fecal calprotectin compared to BF (411±158 vs. 131±29), but this did not reach significance (p=0.1997). Of these groups BF also had the longest duration of disease (15.8±1.6 years) with BM having the shortest (12.8±1.5, n.s.). Conclusion: Our study highlights a significant difference between levels of CRP, ESR and fecal calprotectin in BF as compared to WF. The comparisons between the male counterpart groups did not meet statistical significance however this could be explained by the lower number of males sampled in this cohort. WF in our study had lowest non-invasive marker levels as described above. Comparing endoscopic disease activity in these different groups is needed to further evaluate this disparity. Reason for this difference is unclear, however socioeconomic status, access to health care and geographic environmental influences could likely play important roles.