Group Of Elderly Adults Research Articles

Collateral Damage in the Human Gut Microbiome - Blastocystis Is Significantly Less Prevalent in an Antibiotic-Treated Adult Population Compared to Non-Antibiotic Treated Controls.

Antibiotics can drive the rapid loss of non-target, phylogenetically diverse microorganisms that inhabit the human gut. This so-called “collateral damage” has myriad consequences for host health and antibiotic mediated changes to the gut microbiota have been implicated in the aetiology of many chronic diseases. To date, studies have largely focused on how antibiotics affect the bacterial fraction of the gut microbiome and their impact on non-bacterial members, including prevalent eukaryal species, such as Blastocystis, remains largely unknown. Here we assessed the prevalence and diversity of Blastocystis in an elderly adult group that were in receipt of antibiotics (n = 86) and an equivalent non-antibiotic treated group (n = 88) using a PCR-based approach. This analysis revealed that although similar subtypes were present in both groups, Blastocystis was significantly less prevalent in the antibiotic-treated group (16%) compared to non-antibiotic treated controls (55%); Fisher’s Exact test, p < 0.0001). Given that antibiotics target structures and molecules of prokaryotic cells to kill or inhibit bacterial populations, the most likely explanation for differences in prevalence between both groups is due to secondary extinctions owing to the potential dependence of Blastocystis on bacteria present in the gut microbiome that were negatively affected by antibiotic treatment. Although further work is required to explore this hypothesis in greater detail, these data clearly show that Blastocystis prevalence in human populations is negatively associated with antibiotic treatment. This finding may be relevant to explaining patterns of variation for this microorganism in different human populations and cohorts of interest.

The Effects of Covid-19 on the Digital Literacy of the Elderly: Norms for Digital Inclusion

The current sanitary crisis due to COVID-19 has further evidenced the enormous digital exclusion of older adults. Furthermore, the crisis has urged older adults to adopt new technologies to facilitate their tasks, as well as to provide them with an effective means against loneliness and social isolation caused by the confinement. In light of this, Digital Literacy is necessary for all those excluded from the digital era, who are characterized mainly by little or no ability to effectively use technologies. Nevertheless, detailed studies showing the leap from mixed (Blended Learning, BL) to digital literacy in the elderly have not been published. The objective of the present research was to analyze the level of Digital Literacy with the Digital Literacy Evaluation (DILE) of two groups of elderly adults with different levels of literacy (Group 1: G1, and Group 2: G2) during three stages: BL (Aug–Dec 2019); Transition (Feb–Jun 2020); and Digital (Aug–Dec 2020). Comparisons were made before each educational level (pre-pre-pre) and after each educational level (post-post-post) and during consecutive periods before and after each semester (pre vs post) and throughout different educational levels (G1: Basic 1, B1; Basic 2, B2; and intermediate 1, I1; and G2: Intermediate 1 to 3, I1, I2, and I3). Subsequently, considering all the elderly who had passed at least one of the literacy levels, we worked with a total sample of 176 older adults. The comparisons showed that, before the pandemic, G1’s pre digital literacy levels increased between B1 and B2 and that the differences continued with that increasing trend between the B1 level and the I1 completely digital treatment, and the same was observed for post measurements. On the other hand, for the G2, the differences in the DILE were statistically significant between the pre-condition of I2 (before the pandemic) and the I3 (completely digital treatment); and between the pre-conditions of I1 and I3; the same results were obtained for post treatments. Also, pre vs post scores on the DILE were statistically significant and older adults increased progressively their digital literacy despite the COVID-19 pandemic and jumped to the digital age.

Letter to the Editor: Microbiota in the Respiratory System-A Possible Explanation to Age and Sex Variability in Susceptibility to SARS-CoV-2.

The Human respiratory tract is colonized by a variety of microbes and the microbiota change as we age. In this perspective, literature support is presented for the hypothesis that the respiratory system microbiota could explain the differential age and sex breakdown amongst COVID-19 patients. The number of patients in the older and elderly adult group is higher than the other age groups. The perspective presents the possibility that certain genera of bacteria present in the respiratory system microbiota in children and young adults could be directly or through eliciting an immune response from the host, prevent full-fledged infection of SARS-CoV-2. The possibility also exists that the microbiota in older adults and the elderly population have bacteria that make it easier for the virus to cause infection. I call upon the scientific community to investigate the link between human microbiota and SARS-CoV-2 susceptibility to further understand the viral pathogenesis.

A Mobile App (iBeni) With a Neuropsychological Basis for Cognitive Stimulation for Elderly Adults: Pilot and Validation Study.

BackgroundCognitive impairment is considered one of the most feared chronic conditions among the older adult population since its incidence is approximately twice more frequent than that of dementia. In Mexico, no studies or reports of older adults using technology for cognitive interventions have been published, given that institutions usually frame cognitive stimulation tasks in paper and pencil (ie, in the traditional manner).ObjectiveThe objective of this study was to create and analyze the effect, viability, and impact of a mobile app for cognitive stimulation implemented among a group of elderly adults (over 60 years of age) from the state of Hidalgo in Mexico.MethodsThis study was a nonprobabilistic pilot trial using convenience sampling. An intervention was implemented among a group of 22 older adults between 60 and 80 years of age over 12 weeks. Half of the older adults were stimulated with the mobile app (experimental group) and the other half followed the traditional paper and pencil training (control group). Assessments with the Mini-Mental State Examination (MMSE) and the Neuropsi, a neuropsychological test validated in Mexico, were done before and after both cognitive stimulations.ResultsAccording to the analyzed data, 6/11 (55%) participants from the experimental group obtained better results in their cognitive skills, and 5 (45%) of the adults maintained their score, given that the participants were able to execute the exercises repetitively. Meanwhile, for the control group, only 3/11 (27%) participants obtained better results in the postevaluation. Significant values for results of the MMSE were obtained in the postevaluation for the experimental group compared to the control group, while results did not show significant differences in the Neuropsi. Regarding the validation of the app, all the participants evaluated its pertinence positively.ConclusionsThe intervention data show that the experimental group obtained better results in the postevaluation given that the participants were able to execute the exercises repetitively. The control group could not accomplish this since they had to respond on the manual and no further attempts were provided. However, both groups increased their score in the neuropsychological evaluations. This suggests that a longer and more frequent intervention is required.Registered Report IdentifierRR1-10.2196/9603

The effect of aging and contextual information on manual asymmetry in tool use.

Healthy aging affects manual asymmetries in simple motor tasks, such as unilateral reaching and aiming. The effects of aging on manual asymmetries in the performance of a complex, naturalistic task are unknown, but are relevant for investigating the praxis system. This study examined how aging influences manual asymmetry in different contexts in a tool manipulation task. Fifty healthy, right-hand-dominant young (N = 29; 21.41 ± 2.87years), and elderly (N = 21; mean: 74.14 ± 6.64years) participants performed a 'slicing' gesture in response to a verbal command in two contexts: with (tool) and without the tool (pantomime). For interjoint relationships between shoulder plane of elevation and elbow flexion, a HAND × AGE × CONTEXT interaction existed (F1,43 = 4.746, p = 0.035). In pantomime, interjoint control deviated more in the left (non-dominant) than the right (dominant) limb in the elderly adult group (Wilcoxon, p = 0.010). No such differences existed in the young adult group (Wilcoxon, p = 0.471). Furthermore, contextual information reduced interjoint deviation in young adults when the task was performed with the right (dominant) hand (Wilcoxon, p = 0.001) and in the elderly adults when the task was performed with the left (non-dominant) hand (Wilcoxon, p = 0.012). The presence of the tool did not reduce interjoint deviation for the right hand in the elderly group (Wilcoxon, p = 0.064) or the left hand in the young group (Wilcoxon, p = 0.044). Deviation within trials (i.e., intrasubject deviation) in elbow flexion was higher in the elderly relative to the young adult group (p = 0.003). Finally, resultant peak velocities were smaller (p = 0.002) and cycle duration longer (p < 0.0001) in the elderly adult group. This study provides novel evidence that aging affects manual asymmetries and sensorimotor control in a naturalistic task and warrants that aging research considers the context in which the task is performed.

Thymus and activation-regulated chemokine (TARC)/CCL17 and IgE are associated with elderly asthmatics

BackgroundThe pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE, and inflammatory cytokines including thymus and activation-regulated chemokine (TARC)/CCL17. Because aging is an essential factor in the pathogenesis of asthma, we examined biomarkers related to asthmatic subjects depending on age.ResultsPhysiological indices such as FEV1(forced expiratory capacity in 1 s), FEV1 (% predicted), and FEV1/FVC(forced vital capacity) (%) in asthmatic subjects were lower than those in normal subjects. Total IgE, Der p1 specific IgE, and Der f1 specific IgE were elevated in serum of asthmatics relative to normal individuals. Regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5 in serum and interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemoattractant protein (MCP)-1/CCL2, RANTES, and macrophage inflammatory protein (MIP)-1α/CCL3 in bronchoalveolar lavage fluid (BALF) of asthmatic subjects were higher than in normal individuals. Upon classification of experimental groups depending on age, physiological indices and Der p1-specific IgE (class) were decreased in middle aged adult and elderly adult groups relative to the young adult group. TARC levels in serum were strongly elevated in the elderly adult group relative to the young adult and the middle aged adult groups. TARC in serum was related to total IgE in serum in the elderly adult group.ConclusionsTaken together, although TARC in serum and BALF is not different between normal and asthmatic individuals, TARC increases in serum of elderly asthmatic subjects. The level of TARC has a positive effect on the level of IgE in the elderly adult group. These findings may help us better understand the relationship of pathogenesis of allergic diseases and aging.

Age effect on autobiographical memory specificity: A study on autobiographical memory specificity in elderly survivors of childhood trauma

Background and objectivesPost-traumatic stress disorder (PTSD) is accompanied by altered autobiographical memories (AM) of the traumatic incident itself as well as of non-trauma-related events. Several studies have shown that trauma-exposed individuals developing PTSD have a reduced capacity to access specific past events that are not related to the traumatic event compared to those who do not develop PTSD. However, one study including a group of elderly adults did not find significant differences in AM between PTSD and non-PTSD participants. The present study investigated whether PTSD is associated with impaired AM of trauma-related and non-trauma-related memories in the elderly. MethodForty-four elderly participants, displaced during childhood from former German territories after the end of World War II (WWII), were examined. This group comprised 19 participants with and 25 participants without PTSD. These participants were compared to 23 non-traumatized non-displaced elderly participants. ResultsPTSD, non-PTSD and non-traumatized participants do not differ significantly in their ability to recall specific memories of their past. Moreover, participants with PTSD did not recall more trauma-related memories than non-PTSD participants. LimitationsThe traumatized participants reached for assessment might represent the most resilient individuals, which might constrain generalizability of our results to other trauma populations. ConclusionsThis study confirms preliminary evidence that PTSD is not associated with AM impairment in the elderly. We suggest that aging may alter the relationship between trauma and AM impairment in traumatized participants with PTSD, which need to be confirmed by longitudinal studies.

Relationship between body mass index, bone mineral density, and oral hygiene with periodontal disease in a Mexican elderly group.

The aim of this study was to evaluate the relationship of body mass index (BMI), bone mineral density (BMD) and oral hygiene with periodontal disease (PD) in a group of elderly adults in Mexico City. Material and Methods: A cross-sectional study with a convenience sample of 151 elderly adults was conducted. Before applying the epidemiological survey, each subject was asked to sign an informed consent. Standardization for measuring Ramfjord’s Periodontal Disease Index (PDI), BMI, and Green and Vermilion’s OHI-S was carried out. Descriptive statistics and linear regression models were performed. Results: The 93.4% of the group had PD, 33.8% showed severe gingivitis and 20.5% mild gingivitis. A 28.5% five percent of the group had osteopenia and 18.5% had osteoporosis, being more common in people over 69 years. The 38.4% percent of the group was underweight and 53.0% had poor oral hygiene. Oral hygiene accounted for 63.1% of the PD variance (p=0.0001), figure that did not increase considerably by adding BMD and BMI variables to the regression model. Conclusion: The frequency of PD in this group of elderly adults was high and significantly associated with BMD, BMI, and mainly oral hygiene.

Prevalence of temporomandibular joint disorders in a Mexican elderly group.

Aim: To determine frequency and distribution of temporomandibular disorders (TMD) by age and sex in a group of elderly adults in Mexico City. Material and methods: One hundred and fifty-four older adults in Mexico City were examined in a cross-sectional study. Subjects who had big edentulous gaps (absence of two or more teeth) or those who were fully edentulous, as well as those who refused to participate, were excluded from the study. For the epidemiological survey, diagnostic criteria for Temporomandibular Disorders (DC/TMD), after standardization by a dentist (kappa=0.892), were considered. Results. A 33.1% had some type of TMD, being more common in people between 60 and 69 years old, variable with which it was related (Likelihood Ratio=21.553, p=0.006, X2MH=08.389, p=0.021). A 14.3% reported some type of facial trauma history, behavior that also was statistically significant (X2MH=13.566, p= 0.0001). Disorders that occurred most frequently were: disc displacement with reduction (62.8%) and disc displacement without reduction (9.8%). Conclusions. TMD occurred in one of every three subjects surveyed, showing a relationship with age and trauma history.

A 12-Week Vigorous Exercise Protocol in a Healthy Group of Persons over 65: Study of Physical Function by means of the Senior Fitness Test.

The aim of this study was to assess the effects of vigorous exercise on functional abilities by means of a Senior Fitness Test (SFT) in a group of elderly adults. Twenty healthy and inactive people performed vigorous exercise (VE: 12 men and 8 women, aged 69.6 ± 3.9 years). At the beginning of the study (T0) and after 3 months (T1), each subject's functional ability was tested for muscular strength, agility, cardiovascular fitness, flexibility, and balance. The VE was designed with continuous and interval exercise involving large muscle activities. Functional exercises were performed between 60% and 84% of heart rate reserve (HRR) for a duration of 65 minutes. Five out of the 6 SFTs performed were found significantly improved: Chair Stand (T0 12.4 ± 2.4, T1 13.5 ± 2.6, p < 0.01), Arm Curl (T0 14.2 ± 3.6, T1 16.6 ± 3.6, p < 0.01), 2 min step (T0 98.2 ± 15.7, T1 108.9 ± 16.2, p < 0.01), Chair Sit-and-Reach (T0 −9.9 ± 7.7 cm, T1 1.7 ± 6.3 cm, p < 0.01), and Back Scratch (T0 −15.8 ± 10.9 cm, T1 −8.4 ± 13.1 cm, p < 0.01). Our results suggest that a high intensity protocol and functional exercises can improve functional mobility and muscle endurance in those over 65 years of age. SFTs are an effective method for assessing improvements in the functional capacity of elderly adults.

Effects of flooring on required coefficient of friction: Elderly adult vs. middle-aged adult barefoot gait

The aim of this study was to investigate the effect of flooring on barefoot gait according to age and gender. Two groups of healthy subjects were analyzed: the elderly adult group (EA; 10 healthy subjects) and the middle-aged group (MA; 10 healthy subjects). Each participant was asked to walk at his or her preferred speed over two force plates on the following surfaces: 1) homogeneous vinyl (HOV), 2) carpet, 3) heterogeneous vinyl (HTV) and 4) mixed (in which the first half of the pathway was covered by HOV and the second by HTV). Two force plates (Kistler 9286BA) embedded in the data collection room floor measured the ground reaction forces and friction. The required coefficient of friction (RCOF) was analyzed. For the statistical analysis, a linear mixed-effects model for repeated measures was performed. During barefoot gait, there were differences in the RCOF among the flooring types during the heel contact and toe-off phases. Due to better plantar proprioception during barefoot gait, the EA and MA subjects were able to distinguish differences among the flooring types. Moreover, when the EA were compared with the MA subjects, differences could be observed in the RCOF during the toe-off phase, and gender differences in the RCOF could also be observed during the heel contact phase in barefoot gait.

Frailty among elderly adults in a rural area of Turkey.

BackgroundThe elderly population is growing in Turkey, as it is worldwide. The average age of residents in rural areas of Turkey is relatively high and is gradually increasing. The purpose of this study is to summarize the fitness and frailty of elderly adults living in a rural area of Turkey characterized by a relatively low level of socioeconomic development.Material/MethodsThis study was designed as a prospective, cross-sectional study, and was conducted in a rural area of Kars Province. A total of 168 elderly adults (≥65 years old) from 12 central villages were included in the study. The Fried Frailty Criteria was used to assess the frailty of the participants. In addition to frailty, the physical, social, and mental status of elderly adults was examined.ResultsThe prevalence of frailty in this rural area of Turkey was 7.1%. The study group ranged in age from 65 to 96 years (mean 72.70±7.73 years), and 53.6% were female. Among the elderly adult group, 84.3% had not completed elementary school, and 43.29% had a monthly income of ≤500 Turkish liras ($200). No significant relationship was identified between gender and frailty. There was a statistically significant relationship between frailty and older age, lower education level, lower economic level, co-morbidities, polypharmacy, diabetes, chronic obstructive pulmonary disease, gastric disease, arthritis, generalized pain, benign prostatic hyperplasia, urinary incontinence, auditory impairment, impaired oral care, caregiver burden, impaired cognitive function, depression, or a lack of social support (social isolation).ConclusionsIt is believed that this study will contribute considerably to understanding the health status and needs of elderly adults in Turkey and the health problems of this population as well as to planning the development of public health and geriatric services based on regional needs.

The oral health related quality of life in different groups of senior citizens as measured by the OHIP-14 questionnaire

Abstract Objective: The present study aimed to investigate the impact of the oral health status on the quality of life of groups of elderly adults in urban and rural regions of Greece with different educational

G-34 Free Communication/Poster - Epidemiology of Physical Activity and Health in Youth

PURPOSE: The objective of this study was to assess the effects of exercise on motor abilities by means of the Senior Fitness Test (1) in a group of elderly adults. METHODS: Forty healthy and inactive people were recruited and assigned in two randomized groups of different training activities: a Vigorous Activity Group (VAG:12 men and 8 women, aged 69,60 ± 3,99 years; weight 70,75 ±12,09 kg; height 161,33 ± 6,95 cm), and a Control Activity Group (CAG:13 men and 7 women, aged 70,29±5,71 years; weight 80,28±16,44 kg; height 163,02±12,00 cm). At the beginning of the study (T0) and after 3 months (T1) each subject underwent a thorough medical examination and a series of testing procedures to measure the functional abilities of muscular strength, power and agility. The testing protocol (SFT) included: Chair: Stand, Arm Curl, 2-Minutes Step, Chair: Sit-and-Reach, Back Scratch and 8-Foot Up-and-Go Tests according with Rikli et al.(5).The VAG were designed with aerobic and anaerobic workout along with functional exercises with the use of a platform (step) in accordance to ACSM(3) guidelines in an inclusive range between 60% and 84% of the Heart Rate Reserve (HRR), monitored continuously with heart rate monitor (Polar®)connected to a telemetry system (Hosand®).The CAG were designed with low intensity activities (<60% of HRR) including patterns of real life movements, postural and balance exercises with the use of tools such as fitballs and softballs. Both training protocols were conducted and supervised by fitness professional trainers along a period of 12 weeks (36 sessions of 60 mins/3 times a week) RESULTS:Statistical analysis (2 way Anova for repeated measures) have shown no significant differences neither inter VAG and CAG groups nor intra groups at T0 and T1. Nevertheless a tendency has emerged to an improvement in the VAG in comparison to the CAG, on the upgrading of some motor abilities tested such as the Chair: Stand test. CONCLUSIONS: These results suggest that further studies with a more numerous sample and with a longer protocol could be necessary to elicit an improvement of the motor abilities in such a population. Particularly the need emerges to establish which protocol of physical activity could be more specific and suitable to increase the motor skills described in the SFT

All‐Cause Mortality in Elderly Adults Diagnosed with Cardiorenal Syndrome After an Internal Medicine Unit Admission

All‐Cause Mortality in Elderly Adults Diagnosed with Cardiorenal Syndrome After an Internal Medicine Unit Admission

Higher proportion of inactive Gsk3β in platelets of elderly patients with bipolar disorder: an effect of treatment?

It has been postulated that mood stabilizers inhibit glycogen synthase kinase 3-beta (Gsk3β) activity, mainly through its phosphorylation on serine-9 (Ser9). However, in vivo studies addressing Gsk3β activity in patients with bipolar disorder are scarce. Here, we compare Gsk3β inactivation (as indicated by Ser9-phosphorylation) in platelets of elderly patients with bipolar disorder undergoing clinical treatment and healthy elderly adults not taking medication. Platelet samples were obtained from 37 elderly adults (bipolar disorder = 19, controls = 18). Relative changes in Gsk3β inactivation was estimated by comparing the ratios of phosphorylated Gsk3β to total Gsk3β (p-Gsk3β Ser9/Gsk3β) between the disease and control groups. Phosphorylated-Gsk3β (p < 0.001) and the p-Gsk3β Ser9/Gsk3β ratio (p = 0.006) were elevated in bipolar patients. In the bipolar disorder group, p-Gsk3β Ser9/Gsk3β was positively correlated with serum lithium levels (r = 0.478, p = 0.039). Gsk3β inactivation is higher in this group of elderly adults undergoing treatment for bipolar disorder. However, whether the treatment or the disease causes Gsk3β inactivation was confounded by the lack of an unmedicated, bipolar control group and the non-uniform treatment regimens of the bipolar disorder group. Thus, further studies should help distinguish whether Gsk3β inactivation is an effect of drug treatment or an intrinsic characteristic of bipolar disorder.

Transabdominal Ultrasound Finding and Acute Hepatocellular Injury in Different Cohorts of Elderly Adults with and without Common Bile Duct Stones

Transabdominal Ultrasound Finding and Acute Hepatocellular Injury in Different Cohorts of Elderly Adults with and without Common Bile Duct Stones

Assessing Risk Factors for Unsafe Driving in a Group of Elderly Adults Undergoing Rehabilitation

Assessing Risk Factors for Unsafe Driving in a Group of Elderly Adults Undergoing Rehabilitation

Evaluating the Use of an Assistive Listening Device for Communication Efficiency Using the Diapix Task: A Pilot Study

Objective: The present study aimed to investigate the effects of assistive listening device (ALD) use on communication efficiency in groups of elderly adults with and without hearing impairment during a structured language sampling task. The relationship between self-perceived hearing handicap and communication efficiency was also explored. Method: Twenty-two subjects completed measures of hearing sensitivity, perceived hearing handicap, cognition, and a language sample. One half of the hearing-impaired participants and one half of the normal-hearing group were randomly assigned to use an ALD during a structured conversation task with a naïve partner. Results: The Hearing Loss/No ALD group had significantly more breakdowns than the Hearing Loss/With ALD group. Further, the Hearing Loss/With ALD group performed statistically similar to the two groups without hearing loss. For the normal-hearing groups as well as the Hearing Loss/No ALD group, self-perceived hearing handicap was significantly correlated with the number of communication breakdowns. Conclusion: The results lent preliminary support for the use of ALDs in the management of hearing loss. A case for functional assessment of communication was made to better illuminate causes of perceived communication handicap in the aural rehabilitation of elderly persons with hearing impairment.

The perceptual nature of audiovisual interactions for semantic knowledge in young and elderly adults

Audiovisual interactions for familiar objects are at the core of perception. The nature of these interactions depends on the amodal – sensory abstracted – or modal – sensory-dependent – approach of knowledge. According to these approaches, the interactions should be respectively semantic and indirect or perceptual and direct. This issue is therefore a central question to memory and perception, yet the nature of these interactions remains unexplored in young and elderly adults. We used a cross-modal priming paradigm combined with a visual masking procedure of half of the auditory primes. The data demonstrated similar results in the young and elderly adult groups. The mask interfered with the priming effect in the semantically congruent condition, whereas the mask facilitated the processing of the visual target in the semantically incongruent condition. These findings indicate that audiovisual interactions are perceptual, and support the grounded cognition theory.