One of the most significant and complete approaches to accommodate greater uncertainty than current fuzzy structures is the T-Spherical Fuzzy Set (TSPFS). The primary benefit of TSPFS is that current fuzzy structures are special cases of it. Firstly, some novel TSPF power Heronian mean (TSPFPHM) operators are initiated based on Aczel–Alsina operational laws. These aggregation operators (AOs) have the capacity to eliminate the impact of uncomfortable data and can simultaneously consider the relationships between any two input arguments. Secondly, some elementary properties and core cases with respect to parameters are investigated and found that some of the existing AOs are special cases of the newly initiated aggregation operators. Thirdly, based on these AOs and Aczel–Alsina operational laws a newly advanced technique for order of preference by similarity to ideal solution (TOPSIS)-based method for dealing with multi-attribute group decision-making (MAGDM) problems in a T-Spherical fuzzy framework is established, where the weights of both the decision makers (DMs) and the criteria are completely unknowable. Finally, an illustrative example is provided to evaluate and choose the pharmaceutical firms with the capacity for high-quality, sustainable development in the TSPF environment to demonstrate the usefulness and efficacy. After that, the comparison analysis with other techniques is utilized to demonstrate the coherence and superiority of the recommended approach.