Background A large number of women suffer from sexual dysfunction. Cognitive behavior therapy (CBT) is a psycho-educational therapy the main purpose of which is to help the individual alter their dysfunctional beliefs and behaviors. We investigated the impact of CBT on reproductive-aged women’s sexual function. Methods The present study is a systematic review and meta-analysis in which a number of databases (Web of Science, PubMed, Scopus, Cochrane Library, and Embase) were searched from inception to November 2023. Clinical trials examining the impact of CBT on female sexual dysfunction were included. This study evaluated female sexual function and its components, including satisfaction, discomfort, lubrication, arousal, climax, desire, and assertiveness. We used Review Manager version 5.3 for performing the meta-analysis. P values less than 0.05 were considered statistically significant. Results Seven articles including a total of 448 women with sexual dysfunction were reviewed. The participants’ mean age in the CBT groups was 33.43 ± 6.04 years and that of the control group was 33.24 ± 5.97, which were not significantly different. Our results indicated that CBT is efficient in improving the total score of women’s sexual function (SMD = 1.34, 95% CI = (1.02, 1.65), I2 = 86%), sexual satisfaction, lubrication, desire, orgasm, and assertiveness compared with the control group. However, CBT had no positive effect on reducing sexual pain. Conclusion Based on the result of the current study, CBT can be suggested as an effective treatment method along with other treatments for women with sexual problems.