Objective: To assess the influence of religiosity on the effect the white coat has on hypertensive patients using educational technology. Design and method: This was a prospective randomized educational technology study with four groups of hypertensive patients as follows: Group A (n = 16, 4 women, mean age 55.3 ± 13 years, mean BMI 32.3 ± 6 kg/m2, individual guidance by an embracement strategy, 7 nursing consultations, one every 20 days for a total of 120 days); Group TEDL (n = 13, 5 women, mean age 51.8 ± 7, mean BMI 29.4 ± 5 kg/m2, educational technology distance learning, 7 nursing consultations, one every 20 days for a total of 120 days); Group BL (n = 14, 8 women, mean age 53 ± 9 years, mean BMI 29.6 ± 4.3 kg/m2, the blended learning modality in educational technology, 7 nursing consultations, one every 20 days for a total of 120 days); Control Group (n = 13, 7 women, mean age 57.6 ± 9 years, mean BMI 29.7 ± 6 kg/m2, one nursing consultation at randomization and one on day120). At randomization and on day 120, the following tools were applied: The State-Trait Anxiety Inventory (STAI), The Duke University Religion Index (DUREL), WHOQOL, and ambulatory blood pressure monitoring (ABPM). Results: At randomization, there were no differences in office BP, ABPM, or sociodemographic characteristics between the groups. On day 120, a statistically significant difference was found in ABPM between groups A and BL with respect to nighttime diastolic BP (81.9 ± 11mmHg vs. 95.9 ± 15mmHg, respectively for Group A and Group BL, ANOVA = 0.035) and to the pressure load of nighttime DBP (36.1 ± 27 vs. 70.9 ± 28mmHg, respectively for Group A and Group BL, ANOVA = 0.0294). The Pearson correlation on day 120 between the religiosity scores and both the office BP and the ABPM values showed the following: negative correlation of -0.53 (p = 0.0417) for Group A between the white-coat effect at nighttime diastolic BP and religiosity; negative correlation of -0.93 (p = 0.0188) in the ABPM of Group BL between the standard deviation of the nighttime heart rate and religiosity; positive correlation of the white-coat effect in systolic BP of 0.80 (p = 0.0010) and of the anxiety state of 0.58 (p = 0.0364) with religiosity. Conclusions: Technological Education Strategy associated religious belief potentially can reduces the white-coat effect.