With the rapid development of industry and the increasing population, the balance of groundwater resources has been seriously damaged in China. Quantitative prediction and assessment of the groundwater environment have become necessary for the rational development, use and protection of groundwater resources. Taking the thermal power plant as an example, based on the engineering characteristics and possible pollution of the proposed construction project, the mathematical model of groundwater pollutant migration is established, and the groundwater pollution is predicted by an analytical method. COD, ammonia nitrogen and diesel fuel were selected as predictors to predict the pollutant migration after 100, and 1000 days of pollution occurrence, respectively. The results show that the pollution range will gradually expand with time. After 1000 days, the migration distance of pollutants such as COD and NH3-N reaches 80m, and the influence distance of pollutants such as diesel oil will gradually weaken with time. If not controlled and managed in time, the leakage of pollutants can cause serious pollution to groundwater during the operation of the electric field.