The metropolis of Isfahan that is an important historic and tourist city has faced subsidence in recent decades. The purpose of this study is to evaluate the potential and pattern of progressive subsidence in Isfahan Metropolis, located in the middle part of Iran. For this purpose, geotechnical and hydrogeological studies are conducted. Many samples from the 266 boreholes throughout the study area are studied. Many different tests including grading test, soil type, soil thickness, Atterberg limits, plasticity index, void ratio, and consolidation parameters are done. Also, the fluctuations of groundwater table from 2000 till 2014 were also investigated. Then, the results of the tests were combined with the spatial analysis in the GIS software to determine the critical locations as well as the advancing pattern of progressive subsidence in Isfahan Metropolis. The results revealed that moving from the South-East toward the North-West in the study area, the decline in groundwater head was increased from 4 to 36 m. Based on the results, the most severe subsidence occurred in the western border of the city and was calculated to be about 73 cm over the 14 years period. Additionally, inelastic skeletal specific-storage (Sskv) was calculated for fine-grained sediments in the mentioned time span. According to the interpolation map, the maximum values of the inelastic skeletal specific-storage, as well as the most expected subsidence due to a gradual decline in groundwater head, was occurred in the central part of the city.