Abstract A novel, compact and low-cost four-element multiple-input multiple-output (MIMO) antenna with a high gain is proposed in this work. The suggested antenna structure uses easily accessible substrate material and has been designed and simulated using Ansys HFSS 3D electromagnetic simulation software. The radiating elements are placed orthogonally, and each of them consists of two circular rings. To improve the impedance matching and reduce mutual coupling, the corners are chamfered and partial ground structure is applied. For further enhancement in isolation, Defected Ground Structure (DGS) method is applied which makes the isolation as high as -55 dB. The measured gain of the proposed antenna is more than 12 dB over the considered frequency range. The antenna covers a frequency range from 3.3-6 GHz. The value of diversity gain is found to be more than 9.99 dB and envelope correlation coefficient is less than 0.006 respectively. Also, the mean effective gain, channel capacity loss, and total active reflection coefficient results are within the optimal range. These make the designed antenna suitable for the sub-6 GHz, 5G new radio (NR) n77/n78/n79 where n77 (3.3-4.2 GHz), n78 (3.3-3.8 GHz), and n79 (4.4-5 GHz) bands along with WLAN (5.1-5.8 GHz) applications.