<p indent="0mm">Snow depth is an important parameter that reflects the law of spatiotemporal variation in snow cover and is an indispensable observation variable for studying global and regional climate change and the hydrological cycle. Traditional manual field measurements and ground station observations have limited scopes and cannot fully reflect regional-scale snow conditions. Satellite remote sensing can simultaneously observe surface information over a large area and has been widely used in snow monitoring since the 1970s. Optical remote sensing has difficulty obtaining snow depth information directly through the visible light band and is limited by atmospheric conditions. Microwave remote sensing can penetrate clouds and fog and can effectively capture changes in snow depth. Differential interferometric synthetic aperture radar (D-InSAR) technology uses the differential interferometric phase formed by microwave penetration through the snow layer before and after snowfall to establish a geometric function relationship with the snow depth; it is widely used in regional small-scale snow depth estimation research. However, its estimation accuracy is affected by many factors, such as interferometric image pair coherence, local topography, and snow dielect capability at microwave wavelengths. Based on high-resolution Sentinel-1 SAR data, this study optimizes the snow depth differential interferometric phase unwrapping accuracy by introducing Sentinel-2 optical images and high coherence coefficient regions to select ground control points, which are phase correction benchmarks. Furthermore, introducing field-measured snow parameters such as snow density and satellite local terrain incidence angles based on digital elevation model (DEM) data reduces the error of the differential interferometric phase-slope distance relationship model, thereby enabling estimations of the spatiotemporal distribution of snow depth in the Babao River Basin in the northeastern Qinghai-Tibet Plateau during the 2021 ablation period. Simultaneously, the accuracy of the snow depth estimation ability is evaluated based on the synchronous field measurement data of snow cover satellites. The main factors affecting the accuracy of snow depth estimation are discussed and analysed. Data from 122 ground snow depth measurements (meteorological stations + field measurements) are used to verify the results. The results show that the optimized D-InSAR differential interferometry can improve the snow depth estimation accuracy. The RMSE is <sc>3.9 cm,</sc> the<italic> </italic>MAPE is 20.03%, and the <italic>R</italic><sup>2</sup> is 0.92. However, the estimated snow depth is generally underestimated (MBE%=−16.8%), and the maximum underestimation error of the snow depth is <sc>9.1 cm.</sc> In addition to the influencing factors of D-InSAR system interferometric decorrelation, the estimations are affected by the penetration ability of microwaves in the snow and snow parameters such as stratigraphy structure, temperature and humidity. This limits the ability of differential interferometry to estimate snow depth and is more suitable for dry and homogeneous snow cover. This method allows for more precise and faster monitoring of centimetre-level snow depth changes; at the same time, the underlying surface of the study is relatively simple, and the influence of forest and other vegetation coverage is not considered. In follow-up research, snow cover should be optimized with multi-property and multi-environment interferometric models. An InSAR scattering model with a layered factor is introduced to improve the propagation information inside the snow layer then combined with the multiangle radar measurement of the ascending and descending orbits; experiments are carried out using the penetration ability of more bands in microwaves to reduce interferometric error sources and improve the accuracy of snow depth estimation. This study can provide a scientific reference for D-InSAR snow depth estimation research.