We investigated how changes in grasp configuration affect perceived heaviness in a weight discrimination task in which participants compared the weights of a series of test objects with the weight of a reference object. In different experiments, we varied the width of the grasp, the number of digits employed, the angle of the grasp surface, and the size of the contact area between the digits and the object. We show that objects are perceived to be lighter when lifting with (1) a wide grip in comparison with a narrow grip, (2) five digits in comparison with two digits, and (3) a large contact area in comparison with a small contact area. However, the angle of the contact surfaces did not influence perceived weight. We suggest that changes in central motor commands associated with grasp differences may influence perceived weight, at least under some conditions.