Green Index Research Articles

A novel synchronous fluorescence approach for the simultaneous determination of tafamidis and carvedilol in human plasma at nanogram levels: Compliance with greenness metrics

In this study, a green and highly sensitive synchronous spectrofluorimetric method was developed and validated for the simultaneous estimation of tafamidis (TAF) and carvedilol (CAR) for the first time. The method utilized the inherent fluorescence properties of both drugs, offering high sensitivity and selectivity. The two drugs were measured concurrently at 292 nm and 242 nm for TAF and CAR, respectively at △λ = 100 nm using water as a green diluting solvent. The method was then validated following the International Council for Harmonization (ICH) recommendations, demonstrating acceptable linearity, precision, accuracy, and selectivity within the specified concentration ranges. The concentrations were linear over the ranges of 10.0–600.0 and 1.0–50.0 ng/mL with limits of detection of 2.67 and 0.08 ng/mL for TAF and CAR, respectively. Due to the high sensitivity, the developed method was applied for analysis of the studied drugs in human plasma samples with high %recoveries (98.27–101.82), indicating good bioanalytical applicability. The greenness and eco-friendliness of the designed methodology were verified using the Green Analytical Procedure Index (GAPI) and the Analytical GREEnness (AGREE) tools. The designed approach is the first analytical approach for TAF and CAR simultaneous analysis without the need for any hazardous chemicals or reagents. The high sensitivity, simplicity, rapidity, greenness, and cost-effectiveness of the proposed method make it suitable for the therapeutic drug monitoring of the investigated drugs.

Green-adjusted share prices: A comparison between standard investors and investors with green preferences

We employ the green revenue factors of firms, used in the computation of the FTSE Russell 1000 Green Revenues index to create corresponding green-adjusted share prices. We compute the firm betas, under both the standard and the green-adjusted share pricing. Our findings suggest that tilting of firm stock returns towards green finance could change temporarily asset pricing views. The Fama-French risk factors display very high correlations between the two settings. Nevertheless, there are some significant differences between standard and green-adjusted betas during periods associated with green activism and positive political decisions of financially supporting the global climate action.

When does greener mean slimmer? Longitudinal analysis of green space, trees, grass, and body mass index in a cohort of 50,672 Australians: Exploring potential non-linearities and modifying influences of household relocation and gender

Studies of associations between green space and overweight/obesity are often agnostic to green space type and potential contingencies by gender and household relocation. We investigated associations between total green space, tree canopy, and open grass within 1.6 km road network buffers, on body mass index (BMI) at baseline (n = 110,234; 2005–2009) and follow-up (n=50,672; 2012–2015) using data from the Sax’s Institute’s 45 and Up Study (NSW, Australia). Analyses considered potential non-linearities in these associations and the possibility for effect modification by gender and household relocation. Models were adjusted for age, couple status, region of birth, household income, employment status, educational attainment and housing status. Results revealed that 20 % or more tree canopy, compared to 0–10 % tree canopy was associated with lower BMI. Comparable findings were not observed for open grass or total green space. Nonlinear associations were observed, with a rapid decrease in odds of being overweight/obese at baseline with 20 % tree canopy, that became more stable by 30 % tree canopy. This non-linearity was stronger in females than males. By follow-up, associations indicated potential protective effects with 20 % or more tree canopy for overweight/obesity in females. Logistic regression models examined the odds of becoming a healthy weight at follow-up in overweight/obese individuals at baseline. Results indicated a potentially protective influence of tree canopy on overweight/obesity for people who did not move home (odds ratio (OR) = 1.06, 95 % confidence interval (CI) = 1.01–1.12), but not those who relocated (OR = 0.97, 95 % CI = 0.83–1.11). In sum, conserving and restoring urban tree canopy to at least 20% to 30% of nearby land-use may help to reduce levels of overweight and obesity in the community These benefits may be particularly potent for females and for people who are residentially stable. More open grass, or green space in general, may not have the same benefits for adult overweight/obesity as tree canopy.

Occupancy Comfort Evaluation in Green Building Rating Tools in Malaysia: A Comparative Review

Passive design strategy is the approach that maximizing utilization of natural resources to achieve occupancy comfort which covers the thermal comfort, visual comfort and acoustic comfort while minimizing secondary energy usage. Adapting passive design strategy during building design-stage is beneficial in reducing energy load of the building for long term, furthermore to reduce the energy consumption in day to day building operation. Applying Green Building Rating Tools, GBRT promotes passive design strategy for non-residential building and will assist the building designer to comply with the local and international standard. The minimum requirement of occupancy comfort is captured in GBRT rating system with different approach and intension of the system. This review summarize the coverage of passive design strategy sectors for non-residential building in Malaysia by comparing three GBRT system namely Green Building Index, GBI NCNR, MyCREST ICSAS and GreenRE NRB system. GreenRE NRB seems more aggressive in occupancy comfort evaluation compared to GBI NCNR and MyCREST ICSAS. GreenRE allocates 48.7% of total marks focus on occupancy comfort aspect while GBI and MyCREST allocates 14% and 13.2% respectively from the total score. MyCrest had enforce the mandatory compliance of OTTV, RTTV and Uroof to meet baseline requirement as per MS1525:2019 with zero marks allocation. Based on marks percentage allocation, GBI and MyCrest prioritizing visual comfort while GreenRE give more focus on thermal comfort with higher marks allocation. All rating system give less focus on acoustic comfort. On average, 16.3% of marks covers the thermal comfort, 9% covers visual comfort and 1% cover acoustic comfort. GBI and MyCrest focus more on green building materials which covers the building lifecycle includes water management and waste disposal. All system contributes to Malaysia-UNFCCC ratification of Paris Agreement on 45% GHG reduction in longer runs.

Greenness and practicability assessment of a new HPLC-DAD method for simultaneous determination of three drugs used for a triple-therapy regimen for helicobacter pylori and application to a pharmacokinetic study

Improving the environmental friendliness of laboratory procedures has become very strongly recommended. In this research, several metric tools evaluating the analytical methods, including eco-scale, analytical greenness calculator (AGREE), green analytical procedure index (GAPI), red–green–blue software (RGB) and blue applicability grade index (BAGI) have been used to assess the greenness, performance and practicality of a new useful HPLC-DAD method. The main cause of peptic ulcers and the problems that follow is Helicobacter pylori. Due to the bacteria’s high resistance, different medications are co-administered to overcome the resistance and manage the symptoms. Two antibiotics are mostly used to decrease bacterial resistance in addition to proton pump inhibitors. Pantoprazole, Levofloxacin, and Amoxicillin are co-administered in a triple therapy regimen for suppressing Helicobacter pylori. In this work, the first-time simultaneous estimation of the three medications in rat plasma has been designed and utilized to investigate pharmacokinetics using a new HPLC method with outstanding greenness and practicability. The method involved using a C18 analytical column with an eluent of acetonitrile: 0.03 M Na2HPO4 buffer (20:80, v/v) of 1.5 mL min−1 flow rate. Oxytetracycline was used as an internal standard and the drugs were determined at 230 nm. The validation protocol was adopted according to FDA instructions, and the results proved the ability of the new method to estimate the three medications in rat plasma.

Carbon‐Water Tradeoffs in Old‐Growth and Young Forests of the Pacific Northwest

AbstractDespite much interest in relationships among carbon and water in forests, few studies assess how carbon accumulation scales with water use in forested watersheds with varied histories. This study quantified tree growth, water use efficiency, and carbon‐water tradeoffs of young versus mature/old‐growth forest in three small (13–22 ha) watersheds in the H.J. Andrews Experimental Forest, Oregon, USA. To quantify and scale carbon‐water tradeoffs from trees to watersheds, tree‐ring records and greenness and wetness indices from remote sensing were combined with long‐term vegetation, climate, and streamflow data from young forest watersheds (trees ∼45 years of age) and from a mature/old‐growth forest watershed (trees 150–500 years of age). Biomass production was closely related to water use; water use efficiency (basal area increment per unit of evapotranspiration) was lower; and carbon‐water tradeoffs were steeper in young forest plantations compared with old‐growth forest for which the tree growth record begins in the 1850s. Greenness and wetness indices from Landsat imagery were not significant predictors of streamflow or tree growth over the period 1984 to 2017, and soil C and N did not differ significantly among watersheds. Multiple lines of evidence show that mature and old‐growth forest watersheds store and accumulate more carbon, are more drought resistant, and better sustain water availability compared to young forests. These results provide a basis for reconstructions and predictions that are potentially broadly applicable, because first‐order watersheds occupy 80%–90% of large river basins and study watersheds are representative of forest history in the Pacific Northwest region.

A green, fluorescent probe employing erythrosine-B for tracing the accidental administration of levamisole in milk and plasma samples.

A simple and sensitive fluorescent probe has been developed and optimized to detect the non-intentional administration of levamisole (LVM). LVM is used as an anthelmintic therapy in cows, and hence, its residues appear in the drained milk until 60 hours after administering the drug. Meanwhile, levamisole is known to be an adulterant to cocaine and could be detected in addicts' plasma samples. Owing to its severe side effects, including agranulocytosis, which is lethal in many cases, detection and quantification of LVM in milk and plasma samples are of utmost importance. Therefore, a sensitive and selective analytical method is required for this purpose. This work develops a highly fluorescent probe obtained through the reaction between LVM and erythrosine-B in an acidic medium, where the produced ion pair complex has been measured at 553 nm after excitation at 528 nm. The proposed method provides linearity over the concentration range of 0.5-2.0 μg mL-1 for LVM, with a corresponding detection and quantitation limit of 0.5 and 0.3 μg mL-1. Full validation was performed, permitting the application of the suggested method to perform simple extraction steps. All the applied procedures followed the guidelines offered by green analytical chemistry, where the Green Analytical Procedure Index (GAPI) assessed the greenness of the proposed tool, and the yielded pictograms proved the eco-friendliness of the offered tool.

A nanocopper oxide supported on montmorillonite: synthesis and characterization as a green viscosity index improver additive

A nanocopper oxide supported on montmorillonite: synthesis and characterization as a green viscosity index improver additive

Examining time–frequency quantile dependence between green bond and green equity markets

In the context of the rapidly growing demand for green investments and the need to combat climate change, this study contributes to the emerging literature on green investments by exploring the time–frequency connectedness between green bonds (GBs) and green equities. Specifically, we examine the degree of connection between GBs and green equities, the extent to which these markets influence each other, and which one is the primary net transmitter versus the net receiver of shocks under diverse market conditions. To accomplish these objectives, we use the wavelet-based Quantile-on-Quantile (QQ), dynamic conditional correlation (DCC), portfolio implications, and Quantile VAR approaches. The results show that GBs and green equities have a strong positive connection, depending on time and frequency domains. However, a negative association between GBs and green equities is observed during periods of crisis, highlighting GBs’ ability to hedge green equity portfolios. The portfolio strategies demonstrate that investors require to invest in the Green Economy equity and S&P GB portfolio to reach the highest level of hedging effectiveness. The findings further imply that the Global Water Equity Index transmits the highest spillover to other green assets, while the Green Economy Equity Index receives the most spillover from other assets. The pairwise volatility connectivity reveals that most pairs have minimal quantile dependence, indicating the potential for diversification across the GB and green equity pairs. These findings have significant implications for investors and policymakers concerned with green investments and climate change mitigation.

Digital Inclusive Finance Helps Green Industry in Fujian Province Development

Aims: Digital inclusive finance, as a combination of modern technology and financial services, has developed rapidly in recent years. This new financial model has not only changed the traditional way of providing financial services, but also profoundly affected all aspects of economic and social development. The report of the 18th CPC National Congress made the important decision of "vigorously promoting the construction of ecological civilization " from the strategic height of the sustainable development of the Chinese nation. China's green industry has ushered in a new phase of rapid development. As an important province on the southeast coast of China, Fujian Province, with rich natural resources and vast rural areas, is an important region to promote the development of green industry. Methodology: In this paper, the green industry index of nine prefecture-level cities in Fujian Province from 2011 to 2021 is selected as the explanatory variable, and the development level of digital inclusive finance is taken as the core explanatory variable to explore the impact of digital inclusive finance on the development of green industry in Fujian Province. Results: According to the multiple linear regression, it is found that the level of green industry development is positively correlated with the level of digital inclusive finance development at the 1% significant level, i.e., digital inclusive finance helps to promote the development of green industry in Fujian Province. Conclusion: Based on the findings of the study, the paper puts forward the following recommendations: through the provision of low-cost financing, innovative financial products, digitalized payments and settlements, popularisation of financial education, and the promotion of cooperation, digital inclusive finance can effectively support the development of the green industry. This not only helps to achieve the goal of environmentally sustainable development, but also promotes economic growth, creates employment opportunities and enhances social well-being.

Ecofriendly micellar mediated spectrofluorimetric method for ultrasensitive quantification of the antiparkinsonian drug safinamide in pharmaceutical formulation and spiked human plasma

A novel, highly sensitive and eco-friendly micellar-mediated spectrofluorimetric method was developed and validated for the determination of the novel antiparkinsonian drug safinamide mesylate in the presence of its related precursor impurity, 4-hydroxybenzaldehyde. The proposed approach relies on increasing the inherent fluorescence emission at 296 nm of safinamide, by forming hydrogen bonds between the mentioned drug and sodium dodecyl sulfate in the micellar system using 0.1 N HCl as a solvent, following excitation at 226 nm. A thorough investigation was conducted into the experimental factors affecting spectrofluorimetric behavior of the studied drug. A linearity plot of safinamide over the concentration range of 10.0–1000.0 ng/mL against the relative fluorescence intensities was established. The proposed method demonstrated excellent sensitivity down to the nano-gram level with detection and quantitation limits of 1.91 and 5.79 ng/mL, respectively. The studied drug was effectively determined in Parkimedine® Tablets. Furthermore, the proposed method allows for ultrasensitive quantification of safinamide in spiked human plasma, with satisfactory percentage recovery (98.97–102.28%). Additionally, the greenness assessment using the advanced green certificate classification approach, the complementary green analytical procedure index (Complex-GAPI), and the analytical GREEness metric approach (AGREE), along with the practicality check using the Blue Applicability Grade Index in addition to the all-inclusive overall whiteness evaluation using the RGB-12 model were carried out. The outcomes demonstrated the effectiveness and whiteness of the proposed technique. Clearly, the suggested approach has the advantages of being simple, requiring no pretreatment steps, and relying solely on direct measuring procedures.

Exploration of green index system from the perspective of urban renewal

In the context of China's urban sustainable development, the green index system can be used to assess and monitor the environmental impact and sustainability of urban renewal projects, provide scientific basis for decision makers, and guide urban renewal to develop in a green, low-carbon and sustainable direction. China has incorporated green development and ecological civilization construction into the "13th Five-Year Plan" outline, and clearly put forward the major task of "comprehensively improving the quality of cities" in the "14th Five-Year Plan" outline, in order to accelerate the transformation of urban development mode and carry out urban renewal action. From a macro point of view, in the process of urban renewal, how to use a better evaluation system to plan the future development of urban green space and combine it with design practice is becoming more and more important. From the micro point of view, how the public environment and architectural space in different cities react, reflect, and even promote the process of urban renewal. In many parts of China, urban renewal based on the small block model is encouraged to be widely adopted, and local environmental improvements promote public health and support the transformation of cities to sustainable models based on theoretical, practical and political dimensions. This paper analyzes the urban renewal measures under different scales of landscape, architecture and community, and illustrates their responses to the green index system in urban renewal through cases. From the perspective of urban renewal, the paper combines macro-planning transformation and micro-renewal to analyze the green ecological goals achieved in the process of urban low-carbon development and ecological restoration.

Implementation of green-assessed nanotechnology and quality by design approach for development of optical sensor for determination of tobramycin in ophthalmic formulations and spiked human plasma

A fast eco-friendly colorimetric method was developed for the determination of Tobramycin in drug substance, ophthalmic formulations, and spiked human plasma using silver nanoparticles optical sensor. Even though tobramycin is non-UV–visible absorbing, the developed method is based on measuring the absorbance quenching of silver nanoparticles resulting from the interaction with tobramycin. Different factors affecting the absorbance intensity were studied as; silver nanoparticle concentration, pH, buffer type, and reaction time using quality by design approach. Validation of the proposed method was performed according to ICH guidelines and was found to be accurate, precise, and sensitive. The linearity range of tobramycin was 0.35–4.0 μg/mL. The optical sensor was successfully applied for the determination of Tobramycin in ophthalmic formulations and spiked human plasma without pre-treatment. Additionally, the binding between Tobramycin and PVP- capped silver nanoparticles was studied using molecular docking software. The method was assessed and compared to colorimetric reported methods for the green character using Green Analytical Procedure Index (GAPI) and Analytical GREEnness calculator (AGREE) tools and found to be greener.

Dynamic evaluation of the ecological evolution and quality of arid and semi-arid deserts in the Aibugai River Basin based on an improved remote sensing ecological index

The ecological quality of arid and semi-arid regions (ASRs) is fragile, and the evaluation of dynamic changes in the multi-factor, long-time-series ecological quality of these regions can provide a scientific basis for sustainable regional development. Based on the remote sensing ecological index (RSEI) and its derivative indices dedicated to monitoring ecological quality in ASRs, this study proposes a new modified RSEI (nmRSEI) suitable for ASRs. We used the nmRSEI to evaluate the dynamic changes in the ecological quality and analyse the factors driving these changes in the Aibugai River Basin in the middle of the Inner Mongolian Plateau in the arid core of Asia from 1986 to 2022. The results led to the following conclusions: (1) the use of the nmRSEI helps solve the problems related to the original greenness index, i.e. normalised difference vegetation index, which was readily affected by the soil background in areas with low vegetation coverage; (2) the new dryness index can meet the evaluation requirements for the surface dryness degree in >98.65% of the study area; (3) the introduced salinity index showed a significant negative correlation with the nmRSEI; (4) the nmRSEI exhibits a gradual downward trend (Slope = −0.00326/10a); and (5) temperature was the main factor controlling the ecological quality during the research period. The nmRSEI provides a fast and effective new method for regularly monitoring ecological quality in ASRs. In addition, driving factor analysis can provide theoretical support for ecological protection in ASRs and the realisation of the United Nations 2030 Sustainable Development Goals.

Effects of the utilization of green bonds proceeds on green bond premium

The measurement of premium remains a major challenge in the literature. This study explores the effects of green bond usage on green bond premium using green bonds data extracted from Bloomberg MSCI green bond index between 2007 and 2022. The study leverages fixed effects and pooled regression models to examine whether the green bond premium varies systematically with the issuer's specified use of the green bond's proceeds. The empirical results provide evidence of a positive association between the use of proceeds of green bonds and the premium on green bonds. The green premium of an average of 1–5 basis points across government and corporate issuers is observed. Our findings not only establish the influence of green bond usage on green premium, but also provides further evidence of how issuers can achieve borrowing cost advantage if the proceeds are targeted at environmentally friendly projects that align with investor preferences.

Innovative eco-friendly stability-indicating HPLC-PDA method for simultaneous determination of the emerging antiviral drugs against COVID-19 infection molnupiravir and favipiravir; degradation kinetic studies along with LC-MS based structure elucidation

The adoption of the principles of green chemistry in analytical procedures lowers the negative influence on both people and the environment, which presently has become the key goal. Additionally, the need for advanced analytical techniques for the simultaneous determination of antiviral combinations is highly recommended, one of those novel combinations that recently proved effective emerging antiviral drugs in the treatment of SARS-COV-2 is molnupiravir (MOL) and favipiravir (FAV). Therefore, the establishment of simple and precise stability-indicating HPLC-PDA method for their simultaneous determination is crucial for the probable co-formulation. The stability of MOL was studied along with FAV after forced degradation of both under different stress conditions Separation of MOL, FAV, and their corresponding degradation products was achieved by simple isocratic HPLC-PDA method using a mobile phase comprised of 25.0 mM phosphate buffer (pH 3.0 ± 0.05) − methanol (70:30, v/v) at flow rate 1.0 mL/min. A Zorbax C18 (250 × 4.6 mm, 5 μm; Agilent Technologies, USA) column was used for the separation of the components and the column oven was maintained at 30 °C, the selected wavelength for detection of both analytes and their degradation products was 230.0 nm. The method was linear over the range of 1.0 – 200.0 µg/mL for both MOL and FAV. MOL was found to be susceptible to all forced degradation conditions, namely, acid, alkali, oxidative, thermal, and photodegradation while FAV was susceptible only to acid, alkali, and oxidative degradation. The probable degradation mechanisms were assumed through the evaluation of the MS1 fragmentation pattern of the degradation products, also studying the kinetic behavior of the degradation reactions. Furthermore, the greenness profile for the proposed method was evaluated utilizing the new Complementary Green Analytical Procedure Index method (ComplexGAPI), and analytical greenness (AGREE) metrics with a score of the later one equals to 0.61 that indicated the greenness evaluation of the method. In addition, the new blue applicability grade index (BAGI) which is complementary to the green metrics showed a score of 85.0 that presents a good applicability potential of the method. The proposed method is the first sustainable, stability-indicating method developed for the simultaneous determination of this potential combination that would help in manufacturing both drugs in a fixed-dose drug combination.

Comparison of the impact of school environment on body mass index, physical fitness, and mental health among Chinese adolescents: Correlations, risk factors, intermediary effects

Schools offer prospects to enhance adolescent health by encouraging physical activity. This study contributes to the understanding of adolescent health research, drawing on data from physical fitness and mental health surveys conducted in 2015. The participants included 8,967 seventh-grade students across 45 junior high schools in Dalian, China. By employing multilevel analytical models, this research explores the effects of both the school environment and school neighbourhood environment on adolescents’ body mass index (BMI), physical fitness (PF), and mental health (MH). Additionally, we delve into how physical activities (PA) affect these relationships through stepwise regression analysis. The findings indicate that the school setting significantly affects adolescents’ health outcomes. Specifically, BMI is positively correlated with distance to the nearest amusement park. Conversely, it negatively relates to the extent of school green space and playground, the diversity of land use, and sidewalk density. In terms of PF, positive associations were observed with land use mix and the normalised difference vegetation index (NDVI). However, PF demonstrates negative associations with distance to the nearest parks and beaches. Concerning MH, there is a positive relationship with the proportion of playground, land use mix, sidewalk density, NDVI, and the green view index (GVI). On the contrary, MH is negatively correlated with the distance to park, amusement park, and beach. PA, as an intermediary factor, moderates the relationship between the school environment and both adolescent PF and MH, with mediation effects of 3.713% and 25.193%, respectively. These insights offer valuable theoretical guidance for designing health-promoting schools and urban planning strategies.

Succession and seasonality of a Brazilian secondary tropical dry forest: Phenology and climate moderation

With large tracts of Tropical Dry Forests (TDF) in the Americas previously deforested, many places are currently undergoing secondary ecological succession. These processes vary in time and space, creating a landscape with forests of different ages or successional stages. These secondary forests need moreneed more understanding about how their ecosystem functionality is restored and recovering along the succession path. In particular, it is poorly understood how different successional stages moderate extremes of Essential Climatic Variables (ECV) such as temperature, relative humidity, soil moisture, and the fraction of Absorbed Photosynthetic Active Radiation (fAPAR). This paper, therefore, studies the linkages between high temporal resolution tower-based optical canopy phenology time series and seasonal changes in local ECV conditions between early (10–12 years) and late (50+ years) successional stage TDF in southeastern Brazil. We compare diurnal and seasonal patterns of understory ECVs between early/late plots and investigate the canopy’s Climate Moderating Capacity (CMC). Our data indicate at least 100 mm of precipitation within two weeks is necessary to initiate leaf flushing in this TDF. We also find that soil moisture and daytime air humidity strongly correlate (R2 > 0.75) with seasonal patterns in canopy vegetation greenness indices and fAPAR with a cross-correlation time lag peak of 12–15 days. Our results suggest that the late stage is more effective at cooling (−1.4 ± 0.6 °C vs −0.8 ± 0.6 °C) and reducing daytime evaporation (−0.41 ± 0.2 kPa vs −0.18 ± 0.12 °C) in the understory during the growing season than the early stage. Results suggest that the CMC varies with seasonal canopy leaf area dynamics and with heat and moisture scales, becoming significantly stronger when temperatures and vapour pressure deficits were highest, and correlated strongly with canopy fAPAR dynamics (R2 = 0.82). These findings demonstrate that TDFs can effectively regain microclimatic buffering capacity.

Smart Chemometric‑Assisted Spectrophotometric Approaches for Simultaneous Quantification of Tertiary Combination Recommended for COVID-19 Supportive Treatments with Their Greenness Assessment.

There is an increasing interest of scientific community in developing innovative methodologies for their analysis needs within green analytical chemistry framework. UV spectrophotometry is one of the most promising eco-friendly methods, which is integrated with advanced chemometric tools to enhance the selectivity of the analysis of complex mixtures with severe overlapped signals. Simultaneous determination of a triple-combination of pseudoephedrine hydrochloride (PSE), carbinoxamine maleate (CRX), and paracetamol (PAR) using an artificial intelligence system and multivariate calibration methods. This combination is recently recommended for COVID-19 home-treated patients as part of a symptomatic treatment. Namely, the suggested models are: Artificial Neural Networks, Partial Least Squares, and Principal Component Regression. The proposed algorithms were optimized and developed with the aid of a five-level, three-factor experimental design. The investigated methods were applied over the concentration range of 100-180 μg/mL, 18-16 μg/mL, and 4-12 μg/mL for PSE, CRX, and PAR, respectively. The models validation results demonstrated excellent recoveries (around 98 to 102%), signaling the approaches outstanding resolution capacity for the cited compounds in the presence of common excipients. The outcomes of the studied methods were statistically compared to the official approaches, and no significant difference was found. The suggested models were efficiently employed to determine the selected drugs in their combined tablets without any initial separation steps. The impact of these methods on the environment was evaluated via greenness tools, namely; National Environmental Method Index, Raynie and Driver's green assessment method, analytical Eco-Scale, Green Analytical Procedure Index, and Analytical Greenness Metric. Green chemometric quality assessment of PSE, CRX, and PAR in their pure and pharmaceutical dosage forms. The established approaches are innovative, sustainable, smart, fast, selective, and cost-effective. These models are potential green nominees for routine analysis of the investigated mixture in quality control laboratories.

Measurement of regional green finance development and its coordination with economic development: a study on the Yangtze River Delta region of China

The green transformation of industry and sustainable economic development both require considerable investment. In this regard, green finance that is compatible with economic development can help cope with the massive demand for capital. Taken China’s Yangtze River Delta (YRD) as an example, this study is to measure the coordination degree between green finance and economic development. First, the concept, content and scope of green finance is defined based on the new financial regulation mechanism. Second, a green finance measurement index is built to calculate the green finance index for 30 Chinese provinces by the CFA test. Third, based on the economic structure index, an economic development index is built. Testing the rationality of green financial index and the economic development index, this paper finally measures the degree of coordination between green finance and economic development in the YRD. The results reveal that, first, green finance is a financial instrument that integrates financial industry development, environmental improvement, and economic growth. The measurement of the green financial development index includes the sum of regional green credit, green investment, green securities, and green insurance. Second, after years' development, the comprehensive score of YRD’s coupling coordination degree exceeds 0.8 in 2020, which shows a high level of coordinated development between green finance and economic construction. However, there is a 2-year timing effect between the economic development and green finance index increase, which reveals that green finance development in the YRD requires further policy guidance and support. This study’s findings can provide a theoretical reference and case support for the further development of green finance and related policies in China.