ABSTRACT In this paper, the global motions and wave loads on a large bow-flare ship with the effect of hydro-elasticity, including whipping and springing, are numerically simulated by a CFD-FEM two-way coupled method. The simulation results of ship motions and wave loads by employing the numerical method are demonstrated by verification and validation studies including comparison with tank model experiment results. Additionally, the presented method is applied to study the motions, wave loads and slamming loads of the ship in different wave conditions. The vertical bending moment and vertical shearing force of different frequency components and their distribution along ship length are studied. The characteristics of slamming pressure and green water loads and their spatial distribution are studied. The simulation results indicate that the present numerical method well reproduces ship seakeeping and hydro-elasticity and has potential application values in the design and evaluation of ship wave loads.