Against the backdrop of globalization and ecological civilization, this study aims to analyze the patterns of system coupling coordination development in the Yangtze River Basin under the interacting influences of population growth, ecological conservation, energy utilization, and digital economic development. Using a multisource model, this paper explores the state of coordinated development, spatial–temporal evolution characteristics, and influencing factors in the Yangtze River Basin from 2011 to 2020. The results indicate the following: (1) The overall degree of coupling coordination in the Yangtze River Basin shows better performances in the eastern coastal areas compared to the central and western regions. Over time, the spatial autocorrelation of coupling and coordination increases, exhibiting a significant spatial clustering trend. (2) The Moran’s I index increased from 0.327 to 0.370, with high–high clusters primarily distributed in economically developed coastal provinces, while low–low clusters were observed in remote provinces in the central and western regions, revealing regional development imbalance issues. (3) The driving force analysis shows that green coverage and GDP are the core factors influencing the spatial differentiation of coupling coordinated development. Factors such as the urbanization rate, nighttime light index, and energy consumption had significant impacts in certain years but are generally considered minor factors. The results of this study not only contribute to understanding the dynamic mechanisms of regional coupling and development but also provide a scientific basis for formulating regional coordinated development policies, promoting the achievement of win–win goals of economic growth and ecological civilization in the Yangtze River Basin and similar regions.