Concept Of Green Chemistry Research Articles

White analytical chemistry evaluation of medicines quality screening devices in low- and middle-income countries field settings

Addressing the quality of circulating medicines in low- and middle-Income countries is challenging due to limited access to affordable and rapid laboratory analyses. Moreover, traditional analytical methods generate hazardous waste, posing further environmental and health risks, conflicting with several United Nations Sustainable Development Goals, such as reducing pollution and conserving ecosystems.In response to these environmental challenges, the concept of green analytical chemistry emerged promoting environmentally friendly practices through principles such as reducing chemical use, minimizing energy consumption, and managing waste. Various green metric tools have been developed to assess the environmental impact of analytical methods, but these often neglect the reliability and applicability of the methods. To address this gap, approaches like White Analytical Chemistry (WAC) have been proposed, integrating criteria for environmental safety, reliability, and cost-effectiveness. WAC's principles are categorized into red (fitness for purpose), green (environmental safety), and blue (cost-efficiency) criteria.This study aims to use the WAC approach to provide a holistic comparison of different medicines' quality screening devices, helping developing countries with high SF medicine prevalence make informed choices. Three different situations are investigated: ex-ante evaluation, ex-post evaluation of the qualitative performances and ex-post evaluation of the quantitative performances of the most used medicines’ quality screening devices in low- and middle-income countries field settings.

Development of a novel and useful methodology for the simultaneous analysis of multiclass contaminants in bovine fat.

The instrumental development of tandem mass spectrometers fosters the actual trend in the trace analysis of organic compounds to the development of methods that allow the analysis of contaminants of the most diverse origin in a single analytical sample. The multiclass methods are aligned with the Who's One Health initiative while accomplishing the concepts of green chemistry. However, there are few reports of wide scope multiclass methods for the analysis of contaminants in this matrix. In this work, a method for the simultaneous determination of 62 compounds in bovine fat, was developed and validated following DG-SANTE/11813/2021 guidance. Liquid nitrogen milled fat was extracted with toluene and acetonitrile. Then a clean-up in a cryogenic bath, followed by dispersive solid phase extraction was performed. Residue determination was done using liquid chromatography for 44 compounds and gas chromatography for 18 compounds, both coupled to tandem mass spectrometry in MRM mode. The method was first developed and validated for two ectoparasiticides, then the scope was expanded for the analysis of 13 veterinary drugs and 49 pesticides. Recovery percentages were in the range of 60-134%, high matrix effect was observed in 50% of the scope of the method. Most compounds presented limits of quantification of 10 μg kg-1 in compliance with international requirements. The method was applied to monitor 49 commercial samples to evaluate its performance. Eighty percent of samples contained ethion and 10% had fluazuron, both within MRLs, highlighting the need for proper withdrawal times.

Preparation of PdNi bimetallic loaded amino modified porous carbon material catalyst based on chitosan and its applications

The utilization efficiency of palladium-based catalysts has sharply increased in many catalytic reactions. However, numerous studies have shown that preparing alloys of palladium with other metals has superior catalytic activity than pure palladium. Additionally, hierarchical porous carbon has gradually developed into an excellent carrier for loading bimetallic nanoparticles. In this study, we firstly pyrolyzed chitosan, sodium bicarbonate and nickel nitrate to create highly dispersed porous carbon materials doped with Ni NPs. The carbon materials were then grafted with silane coupling agent (APTMS) to afford them with amino groups on the surface. Taking advantage of the fact that Pd2+ can react with Ni in spontaneous reduction reaction, Pd was deposited on the surface of Ni to produce PdNi bimetallic-loaded carbon catalysts containing amino groups. The resulting catalysts were examined by a series of characterizations and were found to have a hierarchically porous structure and large specific surface area, which increased the number of active sites of the catalysts. In comparison to other Pd catalysts, the PdNi/HPCS-NH2 catalysts displayed remarkable activity for Suzuki coupling reaction and hydro reduction of nitroaromatics, which exhibited a high turnover frequency value (TOF) of 37,857 h−1 and 680.9 h−1, respectively. These were mainly due to the high dispersion of the PdNi NPs and the superior structure of the carriers. Moreover, the catalysts did not experience a significant decline in activity after ten cycles. All in all, this investigation has created a new approach for the fabrication of novel carriers for Pd catalysts, which is in line with the concept of green chemistry and recyclable.

A high-throughput sample preparation approach for the determination of nonsteroidal anti-inflammatory drugs in urine samples through membrane-based microextraction employing a green supramolecular solvent

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs with antipyretic, analgesic, and anti-inflammatory effects widely used worldwide. This study aimed at developing an environmentally friendly and high-throughput sample preparation method for the determination of six NSAIDs in urine samples followed by high-performance liquid chromatography coupled to diode-array detection (HPLC-DAD). The experimental workflow consisted of hollow-fiber microporous membrane liquid-liquid extraction (HF-MMLLE) using a supramolecular solvent immobilized into the porous of polypropylene hollow membranes (1 cm length). These membranes were attached to a 96-well plate system to permit multiple extractions simultaneously. Under the optimized conditions, limits of detection (LODs) and limits of quantification (LOQs) ranged from 6.06 to 30.3 µg/L and from 20 to 100 µg/L, respectively. The linear ranges varied from 20 to 1000 µg/L for indomethacin and diclofenac, from 50 to 1000 µg/L for ketoprofen and ibuprofen, and from 100 to 1000 µg/L for naproxen and fenoprofen. The coefficients of determination (R²) ranged from 0.9735 to 0.9997. Intraday precision ranged from 6.13 to 20.11 %, interday precision varied from 2.87 to 20.72 %, and accuracy ranged from 92.49 to 126.89 %. Moreover, the recently proposed Sample Preparation Metric of Sustainability (SPMS) was employed to evaluate the greenness of the sample preparation technique resulting in a score of 8.0, which is highly satisfactory according to the concepts of green analytical chemistry.

A scalable, chromatography-free, biocatalytic method to produce the xyloglucan heptasaccharide XXXG

Xyloglucan oligosaccharides (XyGOs) are highly branched, complex carbohydrates with a variety of chemical and biotechnological applications. Due to the regular repeating pattern of sidechain substitution of the xyloglucan backbone, well-defined XyGOs are readily accessed for analytical and preparative purposes by specific hydrolysis of the polysaccharide with endo-glucanases. To broaden the application potential of XyGOs, we present here an optimized, scalable method to access large quantities of galactosylated XyGOs by treatment of the bulk agricultural by-product, tamarind kernel powder (TKP), with a highly specific endo-xyloglucanase at high-solids content. Subsequent β-galactosidase treatment reduced XyGO complexity to produce exclusively the branched heptasaccharide XXXG (Xyl3Glc4: [α-D-Xylp-(1 → 6)]-β-D-Glcp-(1 → 4)-[α-D-Xylp-(1 → 6)]-β-D-Glcp-(1 → 4)-[α-D-Xylp-(1 → 6)]-β-D-Glcp-(1 → 4)-D-Glcp). The challenge of removing the co-product galactose was overcome by fermentation with baker’s yeast, thereby avoiding chromatography and other fractionation steps to yield highly pure XXXG. This simplified approach employs many of the core concepts of green chemistry and engineering, enables facile production of 100 g quantities of XyGOs and XXXG for laboratory use, and serves as a guide to further production scale-up for applications, including as prebiotics, plant growth effectors and elicitors, and building blocks for glycoconjugate synthesis.

Micro/nanostructure constructed by in situ growth of SiC nanowires in porous Si3N4 ceramics

AbstractImplant materials with micro/nanostructures bear a closer resemblance with the features of natural bone, which influences the wettability, bone differentiation, and vascularization of materials. However, it is still technically challenging to design the inner wall and surface micro/nanostructures on macroporous bioceramics due to their brittleness. In this work, micro/nanostructured composites with Si3N4 whiskers as a framework, and the (inner) surface covered with SiC nanowires were prepared, denoted as SiC‐nw@Si3N4‐w bioceramics. The synthesis, adopting the green chemistry concept, was utilized from environmental products (carbon evaporated in the furnace at high temperature) and reaction impurities (carbon obtained by polymer pyrolysis and silicon obtained by Si3N4 decomposition) to synthesize SiC nanowires via a vapor‐solid growth mechanism. The prepared SiC‐nw@Si3N4‐w bioceramics have potential applications in bone repair due to their cell adhesion and proliferation.

Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

AbstractIn the present era, the concept of green in organic synthesis has a unique and irreplaceable place. Specifically, nanoparticle has gained much more attention due to its various properties related to the concept of green chemistry. In this context, magnetic nanoparticle has been widely used in the organic synthesis over last one decade. Among organic compounds, pyrazole and its scaffolds are recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules and other valuable candidates. Several commercial drugs such as Sildenafil, Rimonabant, Celecoxib and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. Accordingly, the magnetic nanoparticles have an irreplaceable place in the synthesis of pyrazole derivatives and it is a green and easy methodology to the organic chemists. The present manuscript represents the assimilation of literature pertaining to green aspects of magnetic nanoparticles for the synthesis of highly diversified and valuable derivatives of pyrazole.

Pd-catalysed one-pot and three-component sequential chemoselective double cross-coupling: Synthesis of novel 2-aryl-1,3-azoles from 4-bromophenyl tosylate

One of the principles of green and sustainable chemistry is to use green solvents and one-pot synthetic methods which can eliminate the need for drawn-out separation procedures, purification of intermediate compounds, and the production of waste by-products. Considering these concepts of green and sustainable chemistry, an efficient and novel chemoselective one-pot strategy has been developed for the novel synthesis of 2-Aryl-1,3-azoles via Suzuki and Heck cross-coupling reactions via C-2 arylation of azoles under the discriminate temperature using an ionic liquid as green solvent, promoter and ligand. The chemoselective one-pot synthesis, wide substrate scope, moderate to excellent isolated yield of pure products, mild reaction conditions and recycling/reuse of ionic liquid are highlights of this work.

Turning waste and hazard into thermal conduction material: A promising destination of waste pyrrhotite and polystyrene

The demand for efficient heat dissipation in electronic and electrical equipment enclosures is rising due to the pursuit of higher performance. However, the predominant challenge lies in the use of plastic as the primary material, which lacks favorable thermal conductivity (TC) despite its good machinability. Compared with common fillers, pyrrhotite (Pyr) exhibits moderate TC, insulation properties, and abundant active polysulfide sites on its surface. To turn waste into treasure, we prepared an economic thermal conductive material by powder mixing of Pyr tailings and waste polystyrene (WPS). Hexagonal and monoclinic crystalline Pyr were also prepared respectively, and the results showed that the hexagonal crystalline Pyr exhibited better application potential of TC filler. Furthermore, the strengthening mechanism of polysulfide bonds on the TC was analyzed and demonstrated. The results of the performance evaluation showed that the TC of the composite with optimal conditions improved by 1162.5 % compared to the WPS matrix. Based on the concept of green chemistry and the universality of raw materials, the research provides a method with excellent cost advantages in the future. This method also opens up a new vision for boundary applications such as heat exchange coatings. It is believed that this work provided a green and economic perspective for the disposal of sulfide minerals tailings and waste plastics.

Convenient determination of polystyrene microplastics in soils by gel permeation chromatography-ultraviolet detection analysis

Microplastics (MPs), especially polystyrene microplastics (PS-MPs), have emerged a new worldwide pollutant, prompting significant public concern regarding their detection in environmental media. Analysis of PS-MPs in soil remains as a challenging task for analysts due to the highly intricate matrices. This work presents a practical approach for detecting PS-MPs in soil, which involves dilute HCl-assisted extraction and gel permeation chromatography- ultraviolet detection (GPC-UV) analysis. The presence of MPs in soil was confirmed through the use of a scanning electron microscope in conjunction with energy dispersive spectroscopy investigation. PS-MPs was isolated from soil, by agitating it with a diluted HCl solution, filtering the resulting liquid, and dissolving the residue on the filter with THF. The extractant was subsequently determined by GPC-UV. The introduction of a small amount of HCl into the extraction system was found to greatly expedite the settling of soil in water and enhance the efficacy of extracting PS-MPs in about 30 min. The linear range of PS-MPs was from 1.0 to 100 μg/mL with R2 > 0.999. Good reproducibility was obtained with the intra-day relative standard deviation (RSD, n = 3) of 1.36 % and the inter-day RSD (n = 3) of 4.78 %. The concentration of PS-MPs in soil samples were N.D. - 2.33 μg/g, and the good recoveries were 76.7–100.3 %. The corresponding AFGEEprer score was calculated to be 0.59, indicating the concept of green analytical chemistry for the pretreatment method. These results indicated that this method has a powerful potential for the accurate and rapid determination of PS-MPs in soil.

Retracted:An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and online mass spectrometry detection

Herein we describe an integrated protocol to study the charge heterogeneity of therapeutic proteins. The protocol integrating two workflows, based on imaged capillary isoelectric focusing (icIEF) with fractionation and mass spectrometry (MS) online detection on the same platform, is validated, and can be used for protein charge variant characterization at intact MS and in-depth peptide mapping of collected fractions by high performance liquid chromatography (HPLC). The developed protocol was evaluated based on systematic methodology validation, which is demonstrated to be a robust platform that suits for the heterogeneity characterization of diverse therapeutic proteins with Standard Operating Procedures (SOP), outstanding reproducibility and excellent sensitivity. Especially, the constructed protocol can perform both functions of icIEF fractionation and MS online detection in a unique icIEF platform with high throughput, easy method development and less reagent consumption as comparing to traditional technologies, which “Green Chemistry Concept” helps biopharma industry address urgent challenges during the whole process of discovery, quality control and manufacture release.

High-accuracy quantitative model for phosphate anions in solution based on absorption spectroscopy and machine learning algorithms

The eutrophication pollution caused by excessive phosphorus seriously affects production and daily life of the people. Accurate and rapid detection of phosphate is crucial for water quality management and cleaner production. Currently, most analytical methods for phosphates involve the addition of multiple chemical reagents and are incapable of simultaneous quantification of total phosphorus (TP) and phosphate anions. The environmental friendliness and analytical performance of the methods need to be improved. Here, we established a green and high-accuracy quantitative model based on absorption spectroscopy and machine learning algorithms, which achieved the analysis of TP, H2PO4− and HPO42−. Based on the pH and absorption spectra of phosphate anions, classification and regression tree (CART), random forest (RF), and extreme gradient boosting (XGBoost) algorithms were used to train the original absorption spectra data, first-order derivative spectra data, and multiple feature parameter data of phosphate solutions with pH 4.7–10.0. By comparing the R2, root mean square error (RMSE) and mean absolute error (MAE) evaluation indicators, it was found that the phosphate anions quantitative model established using the CART based on the feature parameters of 187 nm performed the best, R2 > 0.9999, RMSE <3.4 × 10−6, MAE <8.1 × 10−7. The quantitative ranges of TP, H2PO4−, and HPO42− were 3.98 × 10−4—9.33 × 10−4 mol/L, 5.98 × 10−6—4.20 × 10−4 mol/L and 1.53 × 10−6—7.43 × 10−4 mol/L, respectively. Moreover, the quantitative model was optimized based on the spectral characteristics of 14 interfering ions, to improve the model analytical performance for unknown samples. The quantitative model developed in the study achieves accurate analysis of TP, H2PO4− and HPO42−, which is in line with green chemistry concept, and has the potential for prediction and early warning of water environment quality.

Eco‐Friendly Analytical Approaches for the Quantification of Molnupiravir and Favipiravir Using Capillary Zone Electrophoresis and Derivative Ratio Spectrophotometry

AbstractDesigning new validated analytical procedures with a focus on many objectives, such as simplicity, environmental friendliness, analytical effectiveness, and sustainability, has grown to be a top priority in quality control departments. Applying green and white analytical chemistry concepts is no longer a luxury. In this report, two new approaches, Capillary Zone Electrophoresis (CZE) with Photo Diode Array (PDA) detection and derivative ratio spectrophotometric methods, are established and validated for the simultaneous analysis of molnupiravir (MLP) and favipiravir (FAV) in bulk, single dosage forms, and their expected combined dosage forms. For the two drugs, linearity ranges of 5–50 μg/mL and 1–30 μg/mL were achieved using the CZE and spectrophotometric methods, respectively. Both techniques have been validated and used for the estimation of the two medications in lab‐made capsules in accordance with the International Council for Harmonization's (ICH) recommendations. Seven assessment models were used to evaluate the greenness and sustainability of the introduced approaches compared to three previously published HPLC, chemometric, and HPTLC techniques. ChlorTox and BAGI tools are applied for the first time for the evaluation of an analytical procedure. Higher green and sustainable qualities were declared by suggested approaches than by earlier ones.

The effectiveness of natural indigo/kaolinite composite powder in the development of latent fingermarks

BackgroundComposites are materials that have multiple phases and have attracted much attention as they are able to improve physical and chemical properties of an isolated material. In this sense, these composites are commonly used as key components for two purposes: coloring and improving the operational properties; besides that, they have alternative synthesis routes that respect the principles of green chemistry. Thus, this reports the development of a new composite using natural products, indigo and kaolinite, for application in papilloscopy as a new nontoxic fingermark developer.ResultsThe composite was obtained via green procedures and was characterized by spectroscopic and chromatographic techniques. Thus, to investigate the potential of the material as a fingermark developer, different techniques were applied such as depletion, aging, comparison with commercial powder, and development of latent fingermarks on different surfaces. Tests revealed that the composite presented good contrast and adhesion with the latent fingermarks, even after 15 days of deposition.ConclusionsThis study presents a natural indigo/kaolinite composite powder that showed similar or higher efficiency when compared to the commercial fingerprint powder and was able to develop identifiable natural and sebaceous fingermarks.Key points• A composite was formed from eco-friendly materials.• The composite formation follows the concepts of green chemistry and low cost.•The composite was applied as a latent fingermark developer.

The past is the future: from natural acid-base indicators to natural reagents in sustainable analytical chemistry

Abstract This article reviews the use of natural resources in analytical chemistry throughout history. Plant extracts were employed as indicators in chemistry for identifying the acidity or alkalinity of liquids as early as the 1650s. Later, as the industrial revolution altered people’s lives, synthetic chemicals were used instead. Modern techniques of analysis have replaced conventional ones as a result of advancements in physics and technology. The industrial revolution was an era of excitement until the toxic pollutants released from industries severely damaged people and the environment. The concepts of green chemistry and green analytical chemistry were proposed as potential solutions to the problems. The use of natural extracts as chemical analysis reagents has been reconsidered recently as a sustainable alternative. While new technologies such as artificial intelligence (AI) will influence future trends in analytical chemistry development, the primary goal is to move toward sustainable analytical chemistry, which includes using natural reagents and reducing the amount of chemicals consumed and waste produced.

Green chemistry: current status and challenges in Zimbabwe

Abstract Green chemistry involves designing environmentally benign processes that either reduce or eliminate the use and production of hazardous substances in the production of safe chemical products. It aims at minimising waste; eliminating costly treatments; minimising energy and resource consumption, and yielding safer products. On this background, it becomes imperative to promote and establish Green chemistry worldwide, especially in developing countries by incorporating it into school curricula, thus placing it at its core for sustainable development purposes. While Zimbabwe, a sub-Saharan country, has made positive strides in key research areas such as the design of new chemicals, catalysis, solvents, renewable materials, and feedstocks, it still faces some challenges that inhibit the successful inception of the concept of green chemistry. An overview that includes educational curriculum, grants and awards, research, infrastructure, and facilities established to promote green chemistry research and education; challenges currently being faced in implementing the approaches and principles in selected universities; the role played by government bodies, and the public in influencing the criteria to promote the green chemistry concept is given.

Green Chemistry and Sustainability Aspects of Ionic Liquids For Bamboo Preservatives: A Didactical Content Analysis Study

Bamboo has many benefits; it can be used as a construction material and multiple products. However, bamboo has low durability and is easily attacked by fungi and termites. One way to overcome the disadvantages of bamboo is by using environmentally friendly preservatives. Engineering done with ionic liquids can be made into a bamboo preservative that is environmentally friendly and sustainable. This feature of ionic liquids can be integrated into teaching and learning on the concepts of green chemistry and sustainability. This study aimed to produce a concept map and teaching-learning sequences from scientists’ conceptions of green chemistry and sustainability on the topic of ionic liquids. The method used in this study was qualitative content analysis. The research instrument was content analysis. The content analysis processes included literature collection, descriptive analysis, category selection, and material evaluation by didactic aspects. The results of this study are in the form of a concept map, and TLS illustrate the potential consequences of bamboo. Concept map and TLS that connects the relationship between science, technology, and engineering. The results of this study can be used as a basis for designing teaching materials and didactical sequences.Keywords: bamboo, green chemistry, sustainability, ionic liquids. Keywords: bamboo, green chemistry, sustainability, ionic liquids

Construction of biochar-based organohalide-respiring bacterial agent for remediation of 2,4,6-trichlorophenol contaminated soil

Construction of an efficient bio-reductive dechlorination system remains challenging due to the narrow ecological niche and low-growth rate of organohalide-respiring bacteria during field remediation. In this study, a biochar-based organohalide-respiring bacterial agent was obtained, and its performance and effects on indigenous microbial composition, diversity, and inter-relationship in soil were investigated. A well-performing material, Triton X-100 modified biochar (BC600-TX100), was found to have the superior average pore size, specific surface area and hydrophicity, compared to other materials. Interestingly, Pseudomonas aeruginosa CP-1, which is capable of 2,4,6-TCP dechlorination, showed a 348 times higher colonization cell number on BC600-TX100 than that of BC600 after 7 d. Meanwhile, the dechlorination rate in soil showed the highest (0.732 d−1) in the BC600-TX100 bacterial agent than in the other agents. The long-term performance of the BC600-TX100 OHRB agent was also verified, with a stable dechlorination activity over six cycles. Soil microbial community analysis found the addition of the BC600-TX100 OHRB agent significantly increased the relative abundance of genus Pseudomonas from 1.53 % to 11.2 %, and Pseudomonas formed a close interaction relationship with indigenous microorganisms, creating a micro-ecological environment conducive to reductive dechlorination. This study provides a feasible bacterial agent for the in-situ bioremediation of soil contaminated organohalides. Environmental ImplicationHalogenated organic compounds are a type of toxic, refractory, and bio-accumulative persistent compounds widely existed in environment, widely detected in the air, water, and soil. In this study, we provide a feasible bacterial agent for the in-situ bioremediation of soil contaminated halogenated organic compounds. The application of biochar provides new insights for “Turning waste into treasure”, which meets with the concept of green chemistry.

Enhancing the Sustainability of Eco-Friendly Potentiometric Ion-Selective Electrodes for Stability-Indicating Measurement of Ethamsylate: Application in Bulk and Pharmaceutical Formulations.

Through the use of sustainable and green chemistry concepts, scientists need to decrease waste, conserve energy, and develop safe substitutes for hazardous compounds, all for protecting and benefiting society and the environment. Four novel eco-friendly ion selective electrodes (ISE) were generated to determine Ethamsylate (ETM) in bulk powder and different pharmaceutical formulations. The present electrodes were fabricated to clearly distinguish ETM from a variety of inorganic, organic ions, sugars, some common drug excipients and the degradation product, hydroquinone (HQ) of ETM, and thus used for stability-indicating methods. The electrodes fabrication was based on 2-nitrophenyl octyl ether (NPOE) that was employed as a plasticizer in electrodes 1, 2, and 3 within a polymeric matrix of polyvinyl chloride (PVC) except for electrode 4, in which dibutyl sebacate was used as a plasticizer. Electrodes 1 and 2 were fabricated usingtetradodecylammonium bromide as an anionic exchanger, adding 4-sulfocalix-8-arene as an ionophore only to electrode 2 and preparing electrode 1 without incorporation of an ionophore. The fabrication of electrodes 3 and 4 was based on ethamsylate-tetraphenylborate (ETM-TPB) as an ion-association complex in a PVC matrix. The environmental sustainability was assessed using the green analytical procedure index (GAPI), and analytical greenness metric for sample preparation (AGREEprep). Electrodes 1 and 2 had linear dynamic ranges of 10-1-10-5 mol/L and 10-1-10-4 mol/L, respectively, with a Nernstian slope of 49.6 and 53.2 mV/decade, respectively. Electrodes 3 and 4 had linear dynamic ranges of 10-1-10-4 mol/L, with a Nernstian slope of 43.9 and 40.2 mV/decade, respectively. The electrodes' selectivity coefficients showed good selectivity for ETM. The utility of 4-sulfocalix-8-arene as an ionophore had a significant influence on increasing the membrane sensitivity and selectivity of electrode 2 compared to other electrodes. Four novel eco-friendly ISEs were used for determination of ETM in bulk powder and different pharmaceutical formulations. Different experimental parameters were performed to optimize the determination conditions such as solvent mediators, dynamic response time, effect of pH, and temperature. Stability-indicating measurement of ETM in the presence of its degradate HQ and co-formulated drug tranexamic acid. Using new ecological assessment tools to determine whiteness and greenness profiles.

A Review on Green Chemistry and Its Applications

Green Chemistry is most investigated subject these days. It is also known as sustainable chemistry. Green Chemistry and sustainable chemistry are equals that helps to save and conserve resources. It decreases the effect of chemical products on human and atmospheric health. Green Chemistry gives 12 principles that reduce and prevent the utilization and manufacture of hazardous substance. These principles of green chemistry inform about the various issues related to production of chemical compound. Green Chemistry concept started approximately three decades ago. Green chemistry concept for the chemical synthesis and application launched in 1990. This review article purpose to study about Green chemistry and its application and how green chemistry connect to the phytochemistry. By establishing Green Aspiration Level (GAL) that is a quantifiable descriptor, process greenness becomes measurable. Green house gases and global warming are the problem that affected the human and environment health. Green chemistry is used in daily life mainly in medicines. Tree bark and Pine bark extracts are mostly used in anti-microbial, antioxidant and anticancer drugs. The matter that present in environment gives applicable things to the researchers and engineers for the changing and developing a sustainable culture. The word “Green chemistry” is given by the IUPAC which means: the invention, design and utilization of chemical product and process to reduce or to eliminate the use and production of unsafe substance.