Knowledge of Sicilian biology during the past is very important in understanding the complex processes that characterized the population of the Mediterranean Basin. The problem of the first Greek settlement in Sicily is essential in understanding and reconstructing the indigenous biological tissue of an island that was and still is a fundamental crossroads for migratory strategies. In this research we studied ten Sicilian series chronologically attributed to the second and first millennium BC, using discrete cranial traits. The results show that the first biologically significant Greek presence in eastern Sicily could go back to the Bronze Age, while the cosmopolitan Hellenistic city of Syracuse showed the nature of the biological pattern during the first millennium BC. Copyright © 1999 John Wiley & Sons, Ltd.