Physicians generally underestimate their potential to influence social progress, despite substantial precedents for medical professionals leading important societal transformations. The author believes that our times require we challenge the notion that physicians have limited influence beyond clinical settings. Our voice is powerful and important. It needs to be heard. In light of these considerations, the author chose "What Matters" as the theme of the 2024 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting held in Chicago on May 3-6. The topic was reflective of his personal conviction that physicians, by virtue of the public respect and goodwill maintained through their dedication to the art and science of medicine, possess unparalleled potential to enhance both individual and societal health and well-being. The 2024 AANS scientific program committee determined to create an unprecedented program that would allow the community of neurosurgery to engage with some of the greatest minds in American medicine, academics, journalism, technology and public life. All contributors were invited to weave their insights regarding what truly matters into a broad, thought-provoking intellectual and spiritual tapestry. Universally resonant themes such as empathy, innovation, resilience, leadership, value, trust and equity framed the cooperative dialogues, emphasizing our shared humanity and the core values uniting us-despite our differences. The objectives for the 2024 Annual Meeting were ambitious: to consider as a professional community themes of utmost importance to our professional and personal lives; to catalyze a profound reevaluation of our collective objectives; to envision an expanded common mission; and to inspire visionary leaders to collaborate on creating lasting value-both for the patients who are the principal focus of our shared devotion, and for society writ large.