Greater Weight Research Articles

Positions of China and Brazil On De-Dollarization of International Economic Relations and Prospects for Creating a New World Currency

The paper is devoted to the consideration of the PRC and Brazil stances on the de-dollarization of international economic relations and the expansion of the practice of international payments in national currencies. The use of currencies other than the dollar is seen a logical starting point towards liberating the economic relations of the non-Western world from the pressure of the collective West. This pressure, implemented largely due to the fact, that dollar maintains the function of a world currency (according to K. Marx — “world money”), is aimed to tie economic policies and practices of US counterparties, including China and Brazil, to the American currency as a means of manipulating the world economic interests of other countries. The issue of creating international currency units alternative to the dollar is increasingly being raised in political and academic communities. China and Brazil are members of the BRICS forum, which currency’s creation is widely discussed at the international level. The author believes that the likelihood of creating such a currency is now low due to the peculiarities of the global financial and political situation, as well as the insufficient degree of integration within the BRICS itself. If the creation of a new currency (within the framework of a non-Western international structure) begins, then one of the ways of this is the formation of a currency basket in which the yuan can receive the greatest weight. However, the most achievable way of dedollarization seems a broad transition to the use of national currencies in global trade, investment and lending. The next step may be to create not a currency, but a special international unit of account, what is easier to do.

Impact of light spectrum electromagnetic radiation variations on performance and hormonal profiles in laying hens

Avian photopic curves show energy peaks at different wavelengths than humans, particularly in the ultraviolet, yellow, and red range. Therefore, an illumination system with a spectrum tailored for laying hens, encompassing the entire visible spectrum, can enhance performance and welfare. The primary contribution of this study was the development of two Spectral Power Distributions (SPDs) specifically designed for laying hens, with different spectral proportions (S1 and S2), and the evaluation of their effects on productive performance, egg quality, and hormonal levels, compared to conventional white lighting at 3000 K (C). The SPD with a higher emission of red light to increased egg production and egg mass. It also had a lower melatonin concentration, suggesting an inverse relationship with the egg production rate. Regarding egg quality, SPDs specifically designed for laying hens resulted in eggs with greater weight (S1), shell strength (S2), and yolk height (S1 and S2) and diameter (S2). The study’s results indicate that lighting emitting wavelengths within the spectrum visible to poultry, with higher emissions at long wavelengths, appears to be more favorable for laying hens than conventional lighting. A spectrum with higher emissions at shorter wavelengths appears to impair the productive performance of laying hens.

Multivariate process capability analysis with decision-maker preferences

A process capability analysis is an invaluable technique for assessing the efficacy of a system by determining its alignment with customer expectations. In the context of a manufacturing process with multiple correlated variables, the use of multivariate methods is essential for the analysis of quality characteristics. In the literature, there have been various proposals for MPCI (multivariate process capability indices) based on different approaches, including the proportion of non-conforming items or PCA (principal component analysis). In this context, a novel approach to capability analysis with multiple responses of varying degrees of importance has been proposed, termed WAMP (Weighted Arithmetic Mean with Prioritization). The findings indicated that the WAMP method demonstrated greater robustness than the SAM (simple arithmetic mean) and SGM (simple geometric mean) approaches. However, the WAM (weighted arithmetic mean) and WGM (weighted geometric mean) methods also exhibited satisfactory performance in accordance with the established acceptance criteria. The method was evaluated using both simulated and experimental data, demonstrating its efficacy in scenarios with varying degrees of correlation. When a greater weight is assigned to a single original variable, the MPCI is observed to be similar in value to that of the original variable with the highest weight when considered univariately. When equal weights are assigned to two original variables, the MPCI is situated within the capability indices of the original variables with the highest weight. Furthermore, it was observed that the performance of the MPCI improves with an increase in correlation. In conclusion, WAMP has been demonstrated to be a valuable and effective tool for capability analysis in systems with multiple correlated responses of varying degrees of importance.

Why does GLP-1 agonist combined with GIP and/or GCG agonist have greater weight loss effect than GLP-1 agonist alone in obese adults without type 2 diabetes?

Obesity is a chronic condition demanding effective treatment strategies, among which pharmacotherapy plays a critical role. As glucagon-like peptide-1 (GLP-1) agonist approved by the Food and Drug Administration (FDA) for long-term weight management in adults with obesity, liraglutide and semaglutide have great weight loss effect through reducing food intake and delaying gastric emptying. The emergence of unimolecular polypharmacology, which utilizes single molecules to simultaneously target multiple receptors or pathways, marked a revolutionary improvement in GLP-1-based obesity pharmacotherapy. The dual agonist tirzepatide activates both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors and has shown enhanced potency for weight loss compared to conventional GLP-1 mono agonist. Furthermore, emerging data suggests that unimolecular GLP-1/glucagon (GCG) dual agonist, as well as GLP-1/GIP/GCG triple agonist, may offer superior weight loss efficacy over GLP-1 agonist. This review summarizes the comprehensive mechanisms underlying the pronounced advantages of GLP-1/GIP dual agonist, GLP-1/GCG dual agonist and GLP-1/GIP/GCG triple agonist over GLP-1 mono agonist in weight reduction in obese adults without type 2 diabetes. A deeper understanding of these unimolecular multitargeting GLP-1-based agonists will provide insights for their clinical application and guide the development of new drugs for obesity treatment.

Comparative study on the role of various sterols in enhancing ovarian development and metabolic functions in Pacific white shrimp (Litopenaeus vannamei) broodstock

In this study, the Pacific white shrimp (Litopenaeus vannamei) broodstock was considered to rely on dietary sterols for ovarian development because of the inability of the animals to synthesize sterols endogenously. Therefore, we investigated the effects of cholesterol, ergosterol, β-sitosterol, and fucosterol as sterol sources, compared with a control group lacking sterols, on the growth, reproduction, and metabolism of shrimp for a 28-day feeding trial, with an average weight of 32.28 ± 2.00 g in female L. vannamei broodstock. The results demonstrated that cholesterol supplementation significantly enhanced shrimp growth, the gonadosomatic index, and yolk particle deposition, outperforming the other sterol groups and the control group. Notably, while broodstock in the ergosterol group presented the greatest weight gain and yolk granule deposition, they did not achieve the same level of gonadal development or metabolic efficiency as those receiving cholesterol. Additionally, the β-sitosterol group demonstrated a favorable hepatosomatic index but still fell short of the benefits provided by cholesterol. Cholesterol has unique advantages in promoting growth and ovarian development, which may be attributed to its more efficient metabolic utilization and enhanced hormone synthesis, as indicated by the significantly higher serum levels of 17β-estradiol and progesterone in the cholesterol group. Furthermore, cholesterol supplementation significantly upregulated vitellogenin mRNA expression in the hepatopancreas and ovaries, thereby promoting ovarian maturation. Additionally, γ-linolenic acid and 9,10-epoxyoctadecenoic acid were significantly upregulated in the cholesterol group, facilitating ovarian lipid accumulation. In conclusion, the use of cholesterol as a sterol source in the diet significantly promoted the growth and ovarian development of L. vannamei by regulating lipid metabolism and hormone synthesis.

Reliability of online visual and proprioceptive feedback: impact on learning and sensorimotor coding.

Multisensory integration is essential for learning and sensorimotor coding, facilitating learners' adaptation to environmental changes. Recent findings confirm that introducing unreliability into visual feedback enhances the use of motor coding, probably because proprioceptive cues are given greater weight. The present study was designed to test this hypothesis and, more generally, to explore the impact of visual versus proprioceptive cue reliability on learning processes. Participants performed a 12-target pointing sequence 100 times with different combinations of visual and proprioceptive feedback: reliable versus unreliable. Retention tests and intermanual transfer tests were administered 24h later. Results showed that learning and sensorimotor coding were both affected by the different combinations of visual and proprioceptive cue reliability. Fully reliable feedback allowed for the best retention, while fully unreliable feedback resulted in the worst retention. Visual reliability alone mediated the level of visuospatial coding performance in visuospatial transfer, regardless of the level of proprioceptive reliability, and conversely, reliable proprioception combined with unreliable vision provided the optimum sensory environment for motor coding in the motor transfer test. Overall, our study highlighted the essential role of both visual cue reliability and proprioceptive cue reliability -and their interactions- in motor learning and its generalization.

Enhanced HS Code Classification for Import and Export Goods via Multiscale Attention and ERNIE-BiLSTM

Accurate classification of import and export goods’ Harmonized System (HS) codes is essential for ensuring tax security. Applying text classification technologies for HS code classification can significantly enhance the prevention and control of customs tax risks. However, the goods text is a semi-structured one that involves multi-domain Chinese professional vocabulary, which poses challenges for current classification models. These models often suffer from inadequate text representation and imprecise feature extraction. To address these challenges, we propose a novel classification model ERNIE-BiLSTM-Channel attention–Spatial attention (EBLCS). This model integrates ERNIE (Enhanced Representation through Knowledge Integration) with a Bidirectional Long Short-Term Memory Network (BiLSTM) and employs multi-scale attention mechanisms. The ERNIE-BiLSTM model provides a more comprehensive and accurate representation of the goods text, effectively capturing the global features of the text. By introducing channel attention and spatial attention mechanisms, greater weights are assigned to important words and word embedding dimensions, significantly enhancing the model’s ability to perceive key information. The experimental results on a customs dataset demonstrate that the EBLCS model consistently outperforms various baseline models across all evaluation metrics, effectively enhancing the performance of HS code classification.

Efficacy of Anti-obesity Medication (AOM) and Endoscopic Gastric Remodeling (EGR): Analysis of Combination Therapy with Optimal Timing and Agents

Introduction: Endoscopic gastric remodeling (EGR) and anti-obesity medications (AOMs) are effective weight loss therapies. While the efficacy of EGR and AOMs has been established, the effect of combination therapy and its optimal approach remain unknown. Methods: This was a single-center retrospective review of prospectively collected data of patients who underwent EGR. Patients were categorized as: 1) monotherapy – EGR alone, 2) combination therapy – an AOM prescribed within 6 months of EGR and 3) sequential therapy – an AOM prescribed greater than 6 months of EGR. Outcomes included percent total weight loss (%TWL) at 12 months, response rate (≥10%TWL at 12 months) and serious adverse event rate. Results: 208 patients were included. Of these, 65 (34%), 61 (31%) and 82 (35%) underwent monotherapy, combination therapy and sequential therapy, respectively. At 12 months, EGR+GLP-1RA combination therapy achieved the greatest weight loss (23.7±4.6% TWL), while those who began with AOM followed by EGR greater than 6 months later had the lowest weight loss (12.0±7.7%TWL) compared to monotherapy (17.3±10.0% TWL) (p=0.04 and 0.03, respectively). The response rate was 100% for EGR+GLP-1RA combination therapy and 56% for AOM followed by EGR sequential therapy (p=0.02). Conclusion: Combining AOM with EGR appears to result in greater weight loss compared to other strategies, with GLP-1RA as the preferred agent and optimal initiation of both therapies occurring within six months of each other. Prolonged medication use prior to EGR appears to be associated with suboptimal weight loss, suggesting the importance of early referral for adjunctive therapy.

Deciphering Growth Patterns in Korean Children With Sotos Syndrome Through the Development of a Disease-Specific Growth Chart.

Sotos syndrome (SS) is a rare disorder characterized by overgrowth, distinctive facial features, and intellectual disability that is primarily caused by NSD1 pathogenic variants or 5q35 microdeletions. We retrospectively analyzed the clinical characteristics and 339 anthropometric measurements over an average of 4.3 years of follow-up in 57 Korean children with SS. Sex-specific percentile curves for height, weight, and head circumference were developed using a generalized additive model that included factors such as location, scale, and shape. Males with SS demonstrated higher height before the age of 12.0, greater weight before 10.0, and larger head circumference before 15.5 compared to age- and sex-matched controls. Females with SS displayed higher height before 17.0, greater weight before 10.5, and larger head circumference before 12.0 compared to controls. Bone age was advanced compared to chronological age in 40% of males and 8% of females at their last visit. The predicted and target adult heights were not significantly different between groups. In subgroup analysis, the intragenic variant group (n = 48) showed a higher mean standard deviation score of height and weight in males, and head circumference in females compared to the microdeletion group (n = 9). Korean children with genetically confirmed SS exhibited overgrowth in height, weight, and head circumference. Overgrowth phenotypes were more prominent in patients with NSD1 intragenic variants than in those with microdeletions. This is the first study to provide reference data on the growth of Korean children with SS.

Safety and Effectiveness of Naltrexone-Bupropion in Korean Adults with Obesity: Post-Marketing Surveillance Study.

To investigate the safety and effectiveness of naltrexone-bupropion in Korean adults with obesity. This was a prospective, observational multicenter study from April 29, 2016, to April 28, 2022. Individuals with obesity with a body mass index of ≥30 kg/m2 or ≥27 kg/m2 who had obesity-related comorbidities were included. The naltrexone-bupropion dose was gradually titrated weekly from 8/90 to 32/360 mg and maintained at the maximum tolerated dose. In total, 612 and 300 individuals were evaluated for safety and effectiveness, respectively. In total, 41.34% individuals reported drug-related adverse reactions, such as nausea (19.12%), headache (7.68%), and dizziness (5.23%). Older age and comorbidities were significantly associated with adverse events. At 12weeks after reaching the maintenance dose, naltrexone-bupropion 32/360 mg resulted in the greatest weight reduction (-7.21%) compared with other doses, which persisted at week 24 (-7.69%). The naltrexone-bupropion 16/180 mg resulted in significant weight reduction, achieving -5.99% and -9.18% reductions at weeks 12 and 24, similar to that with naltrexone-bupropion 32/360 mg. Young age and no comorbidities were significantly associated >5% weight reduction. Naltrexone-bupropion demonstrated marked stability and weight loss effectiveness, particularly in young individuals with obesity without comorbidities. Therefore, individualized treatment is necessary when prescribing naltrexone-bupropion.

Cardiometabolic characteristics of weight cycling: results from a mid-South regional comprehensive health care system.

The objective of this study was to determine the unique clinical and cardiometabolic risk characteristics of weight-cyclers and identify differences between weight-cyclers and individuals with other weight-change trajectories. A deidentified database of 1,428,204 Vanderbilt University Medical Center patients from 1997 to 2020 was included based on having ≥5 years of recorded weights. Patients with a history of malignant neoplasm, bariatric surgery, implausible BMI (e.g., <15 or >80 kg/m2), or missing documented height were excluded, yielding 83,261 participants categorized by weight trajectory, i.e., weight-stable, weight-gainer, weight-loser, or weight-cycler, based on criteria of ≥5% weight-change thresholds. Additionally, quartiles of average successive weight variability were evaluated to determine the effect of absolute differences among successive weight values. Over half (55%) of participants were weight-cyclers, 23% were weight-gainers, 12% were weight-losers, and 10% were weight-stable over 5 years. Although baseline BMI did not differ among groups, weight-cyclers were more likely to have lower high-density lipoprotein cholesterol and higher blood glucose and triglyceride levels and to have been prescribed antihypertensive, dyslipidemia, and/or antidiabetic therapies. They were also younger and more likely to be smokers. Participants with the greatest weight variability (i.e., highest quartile of average successive weight variability) had higher cardiometabolic risk scores. Weight cycling was highly prevalent but yielded no meaningful overall change in body weight after 5 years. These findings support a paradigm shift in weight management in individuals with overweight/obesity toward reducing cardiometabolic risk with or without weight loss.

Effects of maternal preconception high-fat diet on the fertility of dams and on the somatic parameters and reflex ontogeny of their male offspring

BackgroundFemale consumption of a high-fat diet (HFD) may cause fertility issues and affects offspring development. ObjectiveEvaluate the acute maternal preconception intake of a HFD on the fertility and reproduction parameters of breeding females; and on the somatic parameters and reflex ontogeny of male offspring. MethodsTwenty-four rats were randomized into control (PC; n=12) and high-fat diet group (PHF; n=12) that consumed their respective diets during the 23-day preconception period. After that, 6 rats per group underwent oral glucose tolerance and insulin tolerance tests and were euthanized. The remaining rats were mated, during gestation and lactation, both groups ate a control diet. After birth, the male offspring's somatic parameters and reflexes were assessed. ResultsThe preconception diet caused dyslipidemia in the PHF. The PHF uterus exhibited a higher SFA (50.74 ± 0.32 %), a lower PUFA concentration (35.59 ± 0.33 %), and an increase in arachidonic acid (2.48 ± 0.03 %). PHF rats had hypertrophy in the endometrium, and ovaries with a higher quantity of corpora albicans and immature primordial follicles. The offspring of PHF rats had greater weight (6.70 ± 0.82 g), nasal-anal length (4.93± 0.27 cm), and tail length (1.74 ± 0.12 cm) on the first day of life, and had improved righting reflex, but delayed negative geotaxis reflex. ConclusionsAn acute maternal preconception HFD induced a pro-inflammatory fatty acid profile and changed structure in uterus, altered ovarian follicle profile. Also, potential interference in the size of the pups at birth and in brain development of male offspring.

Weight Changes Are Linked to Adipose Tissue Genes in Overweight Women with Polycystic Ovary Syndrome.

Women with polycystic ovary syndrome (PCOS) have varying difficulties in achieving weight loss by lifestyle intervention, which may depend on adipose tissue metabolism. The objective was to study baseline subcutaneous adipose tissue gene expression as a prediction of weight loss by lifestyle intervention in obese/overweight women with PCOS. This is a secondary analysis of a randomized controlled trial where women with PCOS, aged 18-40 and body mass index (BMI) ≥ 27 were initially randomized to either a 4-month behavioral modification program or minimal intervention according to standard care. Baseline subcutaneous adipose tissue gene expression was related to weight change after the lifestyle intervention. A total of 55 obese/overweight women provided subcutaneous adipose samples at study entry. Weight loss was significant after behavioral modification (-2.2%, p = 0.0014), while there was no significant weight loss in the control group (-1.1%, p = 0.12). In microarray analysis of adipose samples, expression of 40 genes differed significantly between subgroups of those with the greatest weight loss or weight gain. 10 genes were involved in metabolic pathways including glutathione metabolism, gluconeogenesis, and pyruvate metabolism. Results were confirmed by real-time polymerase chain reaction (RT-PCR) in all 55 subjects. Expressions of GSTM5, ANLN, and H3C2 correlated with weight change (R = -0.41, p = 0.002; R = -0.31, p = 0.023 and R = -0.32, p = 0.016, respectively). GSTM5, involved in glutathione metabolism, was the strongest predictor of weight loss, and together with baseline waist-hip ratio (WHR) explained 31% of the variation in body weight change. This study shows that baseline subcutaneous adipose tissue genes play a role for body weight outcome in response to lifestyle intervention in overweight/obese women with PCOS.

Constitutional design preferences: An experimental approach

Abstract A rich literature links the survival of national constitutions to their legitimacy among citizens. However, most studies examine constitutions as a bundle of rights and institutions, and few test the micro-foundations of constitutional preferences explicitly. This article examines how individuals evaluate both the content and flexibility of discrete constitutional elements using a conjoint experiment in Japan. Respondents were asked to rate twenty-six hypothetical constitutions that varied randomly in their enumeration of twelve rights and institutions. We find that citizens generally prefer constitutions that enumerate more provisions, with greater weight placed on human rights than political institutions. This result largely confirms theoretical expectations from earlier work on comparative constitutional design. In addition, political factors, such as partisanship, moderate preferences on issues that have long divided progressives and conservatives in Japan, such as constraints on the military and establishing national emergency provisions. By contrast, socioeconomic characteristics such as income, age, and education do not, suggesting broad demographic consensus on the merits of distinct provisions. Importantly, we further demonstrate that citizens do not trade off constitutional detail and flexibility, as suggested by existing research. Respondents who prefer the enumeration of more provisions do not necessarily want a lower amendment hurdle to facilitate adaptation to new circumstances. Preferences about constitutional flexibility appear to be based on strategic imperatives, notably the desire to cement preferred provisions and prevent changes by future majorities.

Phenomenology of TMD parton distributions in Drell-Yan and Z0 boson production in a hadron structure oriented approach

We present a first practical implementation of a recently proposed hadron structure oriented (HSO) approach to transverse momentum dependent (TMD) phenomenology applied to Drell-Yan-like processes, including lepton pair production at moderate Q2 and Z0 boson production. We compare and contrast general features of our methodology with other common practices and emphasize aspects that we view as improvements. Separately, we discuss the importance of treatments that preserve various theoretical properties of the nonperturbative parts of TMD parametrizations for future applications that have the extraction of hadron structure as a primary goal. These include the HSO’s preservation of a basic TMD parton-model-like framework even while accounting for full TMD factorization and evolution, explicit preservation of the integral relationship between TMD and collinear parton density functions, and the ability to meaningfully compare different theoretical models of nonperturbative TMD parton distributions. In our examples, we show that there is significant sensitivity at moderate Q2 to both the form of the nonperturbative transverse momentum dependence and the parametrization of collinear parton densities. However, we also find that evolving to Q2=MZ2, without fitting, results in a satisfactory postdiction of existing data for Z0 production, nearly independently of the modeling of nonperturbative transverse momentum behavior. We argue that this demonstrates that moderate Q measurements should be given greater weight than high Q measurements in extractions of nonperturbative transverse momentum dependence. We also obtain new extractions of the nonperturbative Collins-Soper kernel within the HSO approach. We discuss its features and compare with some earlier extractions. Published by the American Physical Society 2024

Metabolic outcomes in women 6 months and 2 years after preeclampsia versus normotensive pregnancy: A P4 study.

Preeclampsia is associated with an increased risk of long-term cardiometabolic disease; however, little is known regarding metabolic factors in the early postpartum years potentially contributing to these health disparities. This study aimed to compare body composition, serum biochemical parameters, energy balance and diet 6 months and 2 years after normotensive pregnancy versus preeclampsia. This is the longitudinal metabolic sub-study of the Postpartum Physiology, Psychology and Paediatric cohort study. Women were assessed 6 months and 2 years after normotensive pregnancy (n = 118) and preeclampsia (n = 47). Metabolic measures included anthropometry, body composition via bioelectrical impedance analysis, serum biochemical parameters, diet via a food recall diary, and 24-h energy expenditure using SenseWear Armbands. Two years postpartum, women after preeclampsia continued to have significantly higher weight (median 67.1 kg vs. 63.1 kg, p = .04) compared to normotensive pregnancies, in addition to higher LDL cholesterol levels (2.7 ± 0.8 mmol/L vs. 2.4 ± 0.6 mmol/L, p = .03). These women were also more likely to have an elevated HOMA-IR score ≥2.08 (44% vs. 19%, p = .01). For all women in our study, waist-to-hip ratio, percent fat mass and activity-associated energy expenditure improved overtime. However, HDL cholesterol levels deteriorated, and excess saturated fat and sodium intake persisted from 6 months postpartum. Therefore, two years after preeclampsia, women remain at greater metabolic risk than their normotensive counterparts, with greater weight, LDL cholesterol and markers of insulin resistance, potentially contributing to long-term cardiovascular morbidity and requiring early intervention.

Identifying effects of volatile organic compounds exposure on kidney stone prevalence in U.S. adults: a cross-sectional analysis of NHANES 2007-2020.

Our aim was to comprehensively investigate the relationship between blood volatile organic compounds (VOCs) and kidney stone prevalence for U.S. adults. In this cross-sectional study, 10,052 participants from the 2007-2020 National Health and Nutrition Examination Survey (NHANES) were included. Multivariate logistic regression model was employed to investigate the association between 9 blood VOCs and kidney stones. We explored the dose-response relationship between blood VOCs and kidney stones using restricted cubic spline (RCS) analysis. Additionally, weighted quantile sum (WQS) regression model was performed to assess the overall association of 9 blood VOCs with kidney stones. Finally, subgroup analyses were conducted to identify the findings in different populations at high prevalence. Logistic regression analysis and dose-response risk curves revealed that blood benzene (aOR = 1.308, 95% CI: 1.118-1.530, P = 0.001), blood ethylbenzene (aOR = 1.280, 95% CI: 1.054-1.554, P = 0.013), blood m-/p-xylene (aOR = 1.187, 95% CI: 1.008-1.398, P = 0.040), blood 2,5-dimethylfuran (aOR = 1.319, 95% CI: 1.135-1.533, P < 0.001) and blood furan (aOR = 1.698, 95% CI: 1.305-2.209, P < 0.001) were positively associated with the prevalence of kidney stones. WQS regression analysis revealed that exposure to mixed blood VOCs was positively correlated with kidney stone prevalence (OR = 1.34, 95% CI: 1.14-1.57), with furans carrying the greatest weight. Subgroup analyses suggested that kidney stones were more susceptible to the effects of blood VOCs in young and middle-aged, female, overweight and obese, non-hypertensive, and non-diabetic populations. In this study, the results indicated that high VOC exposure was positively and independently associated with kidney stones in U.S. adults. This finding highlighted the need for public health strategies to reduce VOC exposure and its role in kidney stone prevention and treatment.

Comparison of Growth and Composition of Black Soldier Fly (Hermetia illucens L.) Larvae Reared on Sugarcane By-Products and Other Substrates.

Black soldier fly larvae (BSFL) can convert organic waste into high-quality biomass. In this study, we tested the potential of sugarcane by-products as a food source for BSFL and compared larval development and nutritional value with some other organic substrates. Seven different substrates were used, including carrot pomace (C), carrot pomace and leftover bread (CB) (50/50), bagasse and vinasse (BV), bagasse and molasses (BM), bagasse, vinasse, and molasses (BVM), a mixture of all the above treatments (MX), and university canteen leftovers (UCLs). The larval weight and length were measured for two weeks from day 5 to 19. Then, the BSFL were harvested and analyzed for dry matter, crude protein, oil, ash, mineral, and fatty acid composition. Larval weight and length varied depending on the feeding substrate provided. University canteen leftovers resulted in the BSFL having at least 18% greater length (17.00 mm) and 56% greater weight (3.15 g) compared to other treatments. The highest amounts of protein (38.9%) and oil (39.06%) were observed in the UCL treatment, while the BV treatment larvae had the highest quantities of ash (28.9%) and dry matter (28.0%). The fatty acid profile of the BSFL revealed three-times-higher levels of saturated fatty acids than unsaturated fatty acids in the UCL treatment and was at least twice as high in other treatments. Overall, the BSFL had the best growth on the UCL substrate, and the combination of bagasse and vinasse (BV) was the most appropriate substrate for BSFL development among the sugarcane by-products.

Vision Is Not Required to Elicit Balance Improvements From Beam Walking Practice.

Beam walking is a highly studied assessment of walking balance. Recent research has demonstrated that brief intermittent visual rotations and occlusions can increase the efficacy of beam walking practice on subsequent beam walking without visual perturbations. We sought to examine the influence of full vision removal during practice walking on a treadmill-mounted balance beam. Although visual disruptions improved performance of this task, we hypothesized that removing visual feedback completely would lead to less balance improvements than with normal vision due to the specificity of practice. Twenty healthy young adults trained to walk at a fixed speed on a treadmill-mounted balance beam for 30min, either with, or without, normal vision. We compared their balance pre-, during, and posttraining by calculating their step-offs per minute and the percentage change in step-offs per minute. Balance improved in both groups after training, with no significant difference in percentage change in step-offs between the normal vision and the no vision participants. On average, the no vision participants had twice as many step-offs per minute as the normal vision group during training. Although previous experiments show that intermittent visual perturbations led to large enhancements of the effectiveness of beam walking training, completely removing visual feedback did not alter training effectiveness compared with normal vision training. It is likely a result of sensory reweighting in the absence of vision, where a greater weight was placed on proprioceptive, cutaneous, and vestibular inputs.

Prognostic factors for worsening and improvement in multiple sclerosis using a multistate model.

The long-term disease trajectory of people living with multiple sclerosis (MS) can be improved by initiating efficacious treatment early. More quantitative evidence is needed on factors that affect a patient's risk of disability worsening or possibility of improvement to inform timely treatment decisions. We developed a multistate model to quantify the influence of demographic, clinical, and imaging factors on disability worsening and disability improvement simultaneously across the disability spectrum as measured by the Expanded Disability Status Scale (EDSS). We used clinical trial data from the Novartis-Oxford MS database including ~130,000 EDSS assessments from ~8000 patients, spanning all MS phenotypes. Higher brain volume was positively associated with disability improvement at all disability levels (hazard ratio (HR) = 1.09-1.19; 95% credible interval (CI) = 1.02-1.27). Higher T2 lesion volume was negatively associated with disability improvement up to EDSS 6 (HR = 0.80-0.89; 95% CI = 0.75-0.94). Older age, time since first symptoms, and the number of relapses in the past year were confirmed as predictors of future disability worsening. Brain damage was identified as the most consistent factor limiting the patient's probability for improvements from the earliest stages and across the whole course of MS. Protecting brain integrity early in MS should have greater weight in clinical decision-making.