Effects of dietary chromium (III) picolinate (CrPic) on leanness and fat deposition of pigs have been inconsistent. We investigated the effects of supplemental CrPic on pigs fed high‐fat diets (HFD). Crossbred pigs (n = 32; 9.6 ± 1.6 kg BW) were allotted to 4 treatments with 4 blocks and 2 pigs/pen. Treatments included: 1) low‐fat diet (fat < 3.5%; LFD) with no CrPic, 2) HFD (fat > 30%) with no CrPic, 3) HFD with 1,000 ppb Cr as CrPic, and 4) HFD with 2,000 ppb Cr as CrPic. During d 0 to 56, pigs fed HFD gained faster, consumed less feed, and had lower feed:gain (P < 0.05). CrPic resulted in a quadratic increase (P < 0.05) in feed:gain of pigs fed the HFD. Pigs fed HFD had higher respiration rates than pigs fed LFD on d 41 (P < 0.01) and d 55 (P = 0.06) with no effect of CrPic. Plasma insulin on d 14 linearly decreased with CrPic (P = 0.05). Consumption of HFD resulted in greater carcass weight, perirenal fat, and backfat measures (P < 0.01) and in lower carcass fat‐free lean percentage (P < 0.01) compared with the LFD group. CrPic resulted in linear reductions of carcass weight (P = 0.08) and average carcass backfat (P < 0.05). The effects of CrPic on carcass fat measures were more pronounced in barrows than in gilts. These results indicate that CrPic attenuates some effects of HFD, mainly body fat accretion of pigs, and especially in barrows.