The post-modern age has discarded great narratives such as knowledge and truth which led to crisis of thought such as atheism, agnosticism and liberalism among Muslims. Among the causes surrounding crisis is the epistemological issues. Knowledge that is acquired through scientific methods only is considered valid which causes olther knowledge such as religious knowledge to be seen as ancient, old-fashioned, unscientific and incompatible with the development of the times. This study aims to analyze the philosophy of knowledge according to the Islamic perspective from the aspects of problems, historiography, definitions and sources of knowledge. The Islamic philosophy of knowledge that is centered upon the unity of revelation and reason can be an initial guide in facing the epistemic crisis within the post-modern era. This study uses the of content analysis methods towards books that bring together aspects of the philosophy of science. The study founds that the Islamic philosophy of knowledge to be integrated, comprehensive, and combines religio-philosophy based on the framework of the Quran. In addition, the philosophy of Islamic knowledge also covers a wide field of knowledge including matters related to divinity and religion.